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270 matches found for 1% acetic acid

Improve the Efficiency of Your Impurity Testing: Impurity Solution Mixtures for use in Pharmaceutical Analysis

To ensure the safety of pharmaceutical products, active pharmaceutical ingredients (APIs) need to be tested thoroughly. The accurate detection and control of impurities in drug substances and products is an essential element of ICH and GMP requirements. Reference Materials for these impurities are o...

Online Solid Phase Extraction and LC-MS Analysis of Thyroid Hormones in Human Serum

Introduction Thyroid hormones play critical roles in the regulation of biological processes, such as: growth, metabolism, protein synthesis, and brain development. Specifically, both 3,3’,5,5’-tetraiodo-L-thyronine (thyroxine or T4) and 3,3’,5-triiodo-L-thyronine (T3), are essential for development ...

Extended Lifetime Ethanol Metabolites and Method Development for Ethyl Sulfate and Ethyl Glucuronide Separation

In this study methods are presented for ethanol metabolites ethyl glucuronide (EtG) and ethyl sulfate (EtS) Alcohol abuse remains an epidemic causing widespread health, legal, and economic impacts. Extreme abuse has escalated in volume and cases of alcohol abuse are consistently increasing in younge...

Introduction to PAGE

Polyacrylamide gels are formed by the reaction of acrylamide and bis-acrylamide (N,N’-methylenebisacrylamide) that results in highly cross-linked gel matrix. The gel acts as a sieve through which the proteins move in response to the electric field. Proteins contain an overall positive or negative ch...

Liberase™ DH Research Grade Protocol & Troubleshooting

Product No. LIBDH-RO Selection of the appropriate Liberase Research Grade Enzyme Blend Your current tissue dissociation protocol, and the extent to which you have been successful with traditional collagenase are good guides for selecting the appropriate Liberase Enzyme Blend. Select the Liberase Enz...

Ion Exchange Methodology in Sold Phase Extraction

Counter Ion Selectivity & Ion Exchange Basic Steps In order for electrostatic retention to occur, both analyte and sorbent functional groups must be in their ionized form. This is done through strict pH control of the sample matrix. For basic analytes, the pH should be adjusted to at least 2 pH unit...

Devil's claw (Harpagophytum procumbens) | Plant Profiler

Synonyms / Common Names / Related Terms !ao!ao, //khuripe//khams (Damara/Nama), //xemta='eisa, //xsamsa-//oro (Kung bushman), 6-acetylacteoside, acteoside, afrikanische Teufelskralle (German), Algophytum®, aromatic acids, arpagofito (Italian), Arthrosetten H®, Arthrotabsm®, Artigel®, artiglio del di...

Classical Plant Media Formulations

Classical plant tissue culture media developed years ago by pioneers such as Murashige, Skoog, Gamborg, and others still play a vital role in plant tissue culture research today. Below, find formulation information for these commonly used media. Product No. Description C1416 Chu (N6) basal salt mixt...

Liberase™ DL Research Grade Protocol & Troubleshooting

Product No. LIBDL-RO Selection of the appropriate Liberase Research Grade Enzyme Blend Your current tissue dissociation protocol, and the extent to which you have been successful with traditional collagenase are good guides for selecting the appropriate Liberase Enzyme Blend. Select the Liberase Enz...

Coomassie Stains

We offer a selection of Coomassie® protein stains suitable for a variety of electrophoresis procedures. EZBlue™ and Brilliant Blue Coomassie® stains are designed specifically for staining proteins in SDS-PAGE gels. Refer to our Staining Reagents Selection Chart to choose the right stain for your bio...

Featured article on Peroxide–forming Solvents used in research offered by Sigma-Aldrich.

A significant number of laboratory solvents can undergo autoxidation under normal storage conditions to form unstable and potentially dangerous peroxide by-products. This process is catalyzed by light and heat and occurs when susceptible materials are exposed to atmospheric oxygen. Molecular structu...

Essential Employees Exposures

Air sampling information regarding cleaning agents, disinfectants, and sanitizers The World Health Organization (WHO) declared the novel coronavirus, known as COVID-19, a global pandemic on March 12, 2020, therefore changing our lives in the process. Around the world, different mitigation strategies...

Solid Phase Extraction: Ion Exchange Methodology

Counter Ion Selectivity & Ion Exchange Basic Steps In order for electrostatic retention to occur, both analyte and sorbent functional groups must be in their ionized form. This is done through strict pH control of the sample matrix. For basic analytes, the pH should be adjusted to at least 2 pH unit...

Glycine Transporters

Glycine is an important inhibitory neurotransmitter in the mammalian CNS where it acts via strychnine-sensitive glycine receptors. It can also produce excitatory effects via strychnine-insensitive glycine sites located on NMDA glutamate receptors. Extracellular glycine levels can be regulated via up...

Tetrahydrofuran - High Purity Solvents

Tetrahydrofuran, THF, is a heterocyclic compound with oxygen. The molecular formula for THF is (CH2)4O. It is a colorless liquid. Heterocyclic compounds are cyclic hydrocarbons that contain an atom in the ring of a cyclic other than a carbon atom, hence the prefix "hetero". — These atoms could be su...

NIR Fluorescence Dyes

• • Download PDF • An increasing demand for red emitting fluorescent dyes, useful in life science applications such as antibody and protein labeling, prompted us to develop new improved long wavelength markers for use in the visible/near-infrared (NIR) region. Tracy 645 and Tracy 652 (see Table 1) a...

Acetic acid-d4 - NMR Solvents

Sigma-Aldrich Online Catalog Product List: Acetic acid-d4

Liberase™ Research Grade Selection Kit Protocol & Troubleshooting

Product No. 05401046001 Selection of the appropriate Liberase Research Grade Enzyme Blend Your current tissue dissociation protocol, and the extent to which you have been successful with traditional collagenase are good guides for selecting the appropriate Liberase Enzyme Blend. Select the Liberase ...

Chiral Phosphoric Acids

Aldrich ChemFiles 2007, 7.9, 11. BINOL-derived phosphoric acids are capable of catalyzing a range of interesting processes of which nucleophilic addition reactions to imine substrates are particularly noteworthy. List and coworkers reported1 a direct Pictet-Spengler reaction with a range of aldehyde...

Probiotics and Human Health

At the beginning of the 20th century, probiotics were thought to have a beneficial effect to the host by improving the intestinal microbial balance. Through his studies and observations, the Russian biologist Metchnikoff noted people from cultures which consumed large amounts of fermented milk, gene...

PharmaGrade™ product portfolio

Our PharmaGrade™ product portfolio of specialty chemicals, buffers, and amino acids is being integrated into the Emprove® Program. The PharmaGrade™ portfolio of biopharma raw materials was developed to resolve a fundamental bioprocess challenge: sourcing specialized raw materials with transparent an...

Toluene - High Purity Solvents

Aromatic hydrocarbon Scientific uses: • Solvent for carbon nanomaterials • Fullerene indicator • Opens red blood cells in biochemistry • Coolant for sodium heat traps Whether you need HPLC toluene, ACS toluene, anhydrous toluene or one of the other grades available, we offer the right product for yo...

Liberase™ TH Research Grade Protocol & Troubleshooting

Product No. LIBTH-RO Selection of the appropriate Liberase Research Grade Enzyme Blend Your current tissue dissociation protocol, and the extent to which you have been successful with traditional collagenase are good guides for selecting the appropriate Liberase Enzyme Blend. Select the Liberase Enz...

Performance of Whatman™ 40 and 41 Quantitative Ashless Filter Paper

The aim of this work was to demonstrate the performance of Whatman™ Grade 40 and Grade 41 quantitative ashless filter paper in specific mining industry applications. Whatman™ Grade 40 and Grade 41 filter paper was evaluated in three metal content tests typically used in quality control laboratories—...

Scale-Up Guide: Copper C-N Cross-Coupling Reaction

All of the catalysts used in the kit are sensitive to air and moisture in their commercially available form. Please see the catalyst MSDS or product detail page for details on handling and storage. To best enable scale-up success, the use of glove box is highly recommended. However, modified bench t...

Chromatofocusing: Principles and Methods

Related Links • Sample Preparation in Ion Exchange Chromatography • Non-volatile and Volatile Buffer Systems • Column packing and preparation for Ion Exchange Chromatography & Chromatafocusing • Selection of Purification Equipment • Column Cleaning for Ion Exchange Chromatography and Chromatofocusin...

Normal-Phase Methodology in Solid Phase Extraction

Basic Steps Common Normal-Phase Solvents Non-polar Sample Matrix/ Mobile Phase Environment In order for polar retention to occur between the sorbent and the sample, the analyte must be introduced to the SPE device in a non-polar sample or mobile phase environment. Therefore, typical sample matrices ...

Accurate Biological Testing for Amphetamine and Methamphetamine Abuse using Chiral HPLC and MS Detection

Denise Wallworth and Hugh Cramer, Supelco denise.wallworth@sial.com In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine. Methamphetamine and amphetamine, powerful CNS stimulants...

Chemical Compatibility Guide for MultiScreen® Filter Plates

Ratings are based on 100% or concentrated solutions, unless otherwise indicated. Aromatic hydrocarbons (especially ketones, DMF, DMAC, DMSO, THF, acetonitrile) and chlorinated hydrocarbons will attack both membranes and plastics. A chemical listed as NR may be suitable in low concentrations for shor...

Rink Acid Resins

Rink acid resins are extremely acid-sensitive supports. Protected peptide acid fragments can be obtained without any loss of sidechain protection functionality by applying 10% acetic acid in dichloromethane. Consecutive coupling steps during chain elongation should be carried out under basic conditi...