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Search term:"N-Heterocycles"

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47 matches found for N-Heterocycles

Brominated Heterocycles and N-Oxides - Baran Functionalized Building Blocks

Products Commercialized from the Organic Letters paper "Regioselective Bromination of Fused Heterocyclic N-Oxides"

SnAP Reagents

Saturated N-heterocyclic building blocks are of growing importance but their installation has been challenging due to poor commercial availability and the often long, laborious synthetic routes needed to form these ring systems. SnAP Reagents are an ever-expanding class of reagents, which are now av...

SLAP Reagents for Piperazine Synthesis

Related Links • Chemical Synthesis Technology Spotlights • Professor Product Portal • Cross-Coupling • New Products for Chemical Synthesis The Bode group has recently developed and commercialized a number of SnAP (stannyl amine protocol) reagents that cross-couple with aldehydes and ketones to provi...

Bode Kinetic Resolution

Related Links • Kwon Phosphines Despite the widespread use of chiral amines and amides in modern pharmaceutical and agrochemical compounds, synthetic access to such building blocks, particularly in an enantioenriched form, has traditionally been very challenging. In many cases, especially for second...

Jeffrey Bode Group – Professor Product Portal

Related Links • VIEW PRODUCT LIST • Professor Product Portal • Organic Synthetic Chemistry • Catalysis and Inorganic Chemistry • Chemical Biology • Biomaterials Professor Product Portal Index Professor Jeffrey W. Bode The Bode Group aims to develop new reactions and reagents for the synthesis of com...

Trost Ligands

• • Download PDF • Palladium-catalyzed asymmetric allylic alkylation (AAA) has proven to be an exceptionally powerful method for the efficient construction of stereogenic centers. In sharp contrast to many other catalytic methods, AAA has the ability to form multiple types of bonds (C–C, C–O, C–S, C...

Asymmetric Allylic Alkylation in Chemical Synthesis

Introduction Advantages Pd-Catalyzed Asymmetric Allylic Alkylation: • Carbon Nucleophiles • Oxygen Nucleophiles • Nitrogen Nucleophiles • Sulfur Nucleophiles Asymmetric Allylic Alkylation: • Molybdenum-catalyzed Reactions Product Information Introduction Palladium-catalyzed asymmetric allylic alkyla...

Gold Catalysts

Prior to the 1980s, gold was regarded as having little catalytic activity. Recent advancements, spearheaded by F. Dean Toste (University of California, Berkeley) and others, have propelled gold into the forefront of transition metal catalysis. In particular, phosphine-ligated gold(I) complexes have ...

Asymmetric Allylic Alkylation - Advantages and Applications in Chemical Synthesis

. Introduction . Advantages . Representative Application . Pd-Catalyzed Asymmetric Allylic Alkylation: Carbon Nucleophiles . Pd-Catalyzed Asymmetric Allylic Alkylation: Oxygen Nucleophiles . Pd-Catalyzed Asymmetric Allylic Alkylation: Nitrogen Nucleophiles . Pd-Catalyzed Asymmetric Allylic Alkylatio...

arylacetamide deacetylase
Synonyms CES5A1, DAC
Species Human (13) , Species Mouse (67758) , Species Rat (57300) , Species dog (477115) , Species Horse (100056411) , Species cow (519557) , Species domestic cat (101096344) , Species domestic guinea pig (100723674) , Species naked mole-rat (101706394)
Summary: Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

A Bulky Biaryl Phosphine Ligand Allows for Palladium-Catalyzed Amidation of Five-Membered Heterocycles as Electrophiles

The palladium-catalyzed cascade reaction of 2-chloroaryl sulfonates with arylamine and amide nucleophiles provides direct access to�N-arylbenzimidazoles. This strategy selectively produces the heterocycles based on chemoselective oxidative addition. 2-Chloroaryl triflates (Tf) produce one regioisome...

Carbazoles - Heterocyclic Building Blocks

Carbazole derivatives are tricyclic aromatic heterocycles consisting of two benzene rings fused on either side of a five-membered nitrogen-containing ring. The intriguing structural features and promising pharmacological activities of these natural products have led to enormous growth in carbazole c...

Pyridines - Halogenated Heterocycles

Pyridines are heterocyclic six-membered aromatic compounds containing a single nitrogen atom. Pyridines are a class of important heterocycles and appear in many naturally occurring bioactive compounds, pharmaceutical molecules, and chiral ligands in polysubstituted forms. The pyridine moiety is pres...

Carbazoles - Halogenated Heterocycles

Carbazole derivatives are tricyclic aromatic heterocycles consisting of two benzene rings fused on either side of a five-membered nitrogen-containing ring. The intriguing structural features and promising pharmacological activities of these natural products have led to enormous growth in carbazole c...

Pyridines - Heterocyclic Building Blocks

Pyridines are heterocyclic six-membered aromatic compounds containing a single nitrogen atom. Pyridines are a class of important heterocycles and appear in many naturally occurring bioactive compounds, pharmaceutical molecules, and chiral ligands in polysubstituted forms. The pyridine moiety is pres...

Benzimidazoles - Heterocyclic Building Blocks

Benzimidazole, a heterocyclic aromatic organic compound consisting of a fusion of benzene and imidazole, in an extension of the well-elaborated imidazole system, has been used as a carbon skeleton for N-heterocyclic carbenes, usually used as ligand for transition metal complexes. Pharmacological com...

SnAP Reagents - Organometallic Reagents

In collaboration with Professor Jeffrey Bode, Aldrich Chemistry is pleased to introduce the SnAP Reagents. The SnAP Reagents alleviate the challenges of synthesizing novel saturated N-heterocyclic building blocks and allow for the direct synthesis of saturated N-heterocycles, which are compatible wi...

Morpholines/Thiomorpholines - Heterocyclic Building Blocks

Morpholines are six-membered heterocycles featuring both amine and ether functional groups. Substituted morpholine derivatives are the core of various natural products and biologically active compounds. This class of compounds has found important applications in pharmaceuticals and in agricultural u...

SLAP Reagents - Organometallic Reagents

Silicon amine protocol (SLAP) reagents are now available in collaboration with Professor Dr. Jeffrey Bode to form N-unprotected piperazines. Similar in function to the SnAP Reagents, the SLAP derivatives are free of tin and instead use photocatalytic cross-coupling with Ir[(ppy)2dtbbpy]PF6 (747769) ...

Imidazolines/Imidazolidines - Halogenated Heterocycles

Imidazolines and are important heterocycles found in many biologically active compounds. Imidazolines are biologically active pharmacophores and synthetic intermediates in medicinal chemistry. Imidazolines are also used as chiral catalysts, chiral auxiliaries, and ligands for asymmetric catalysis. I...

Benzimidazoles - Halogenated Heterocycles

Benzimidazole, a heterocyclic aromatic organic compound consisting of a fusion of benzene and imidazole, in an extension of the well-elaborated imidazole system, has been used as a carbon skeleton for N-heterocyclic carbenes, usually used as ligand for transition metal complexes. Pharmacological com...

Imidazolines/Imidazolidines - Heterocyclic Building Blocks

Imidazolines and are important heterocycles found in many biologically active compounds. Imidazolines are biologically active pharmacophores and synthetic intermediates in medicinal chemistry. Imidazolines are also used as chiral catalysts, chiral auxiliaries, and ligands for asymmetric catalysis. I...

Rh2(esp)2 Catalyst

By substituting tetramethylated m-benzenediproprionic acid 1 via a decarboxylative metathesis of Rh2(OAc)4 (Scheme 1), the Du Bois group at Stanford has improved the catalytic performance of Rh with respect to the oxidative C–H activation of sulfamate, sulfamide, carbamate, urea, and guanidine subst...

Buchwald Phosphine Ligands - Technical Article

. For C-C, C-N, and C-O Bond Formation . Additional Information . Materials List For C-C, C-N, and C-O Bond Formation: Over the past several years, the Buchwald group has developed a series of bulky electron-rich phosphines that have garnered much attention for their ability to effect various C–C, C...

Late Stage Functionalization | Functionalization

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Janis Louie Group – Professor Product Portal

Professor Product Portal Index Professor Janis Louie Professor Louie's research focuses on the discovery and mechanistic understanding of new reactions catalyzed by transition metal complexes. She has developed a highly active Ni(0) catalyst that effectively mediates a variety of cycloaddition and i...

Neil Garg Group - Professor Product Portal

Related Links • VIEW PRODUCT LIST • Professor Product Portal • Organic Synthetic Chemistry Professor Product Portal Index Professor Neil Garg The Garg group develops methods for the synthesis of natural products and pharmaceuticals. One key method pertains to heterocyclic arynes, such as indolynes a...

Dess–Martin Periodinane

Dess–Martin Periodinane (DMP) is among the most widely used reagents for the mild oxidation of alcohols to aldehydes and ketones.1 The neutral conditions of the oxidation reaction make it a suitable choice in syntheses of sensitive, functionally complex intermediates. When used in hydrophilic ionic ...

Professor Product Portal - Baran Group

Professor Product Portal Index Professor Phil S. Baran Congratulations to Dr. Baran for being named a 2013 MacArthur Fellow. Learn more The Baran Group works with Sigma-Aldrich in providing a portfolio of zinc-based reagents promoting difluoromethylation, trifluoromethylation, trifluoroethylation an...

Pfaltz Group - Professor Product Portal

Professor Product Portal Index Professor Andreas Pfaltz Andreas Pfaltz has a longstanding interest in the design of chiral ligands for asymmetric catalysis. The semicorrins developed in his group served as the prototype for an important family of nitrogen ligands, the bisoxazolines, which have found...

Palau’Chlor®: Easily and Selectively Functionalize Lead Compounds

Aryl chlorides are commonly used in cross-coupling reactions and can serve as key intermediates towards the synthesis of pharmaceutical drug candidates and natural products. Therefore, the addition of chlorine onto synthetic compounds can lead to the diversity of functionalized compounds. Current ch...