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Search term:"neurons"

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209 matches found for neurons

Neurons - Primary Cells

Sigma-Aldrich Online Catalog Product List: Neurons

Primary neuron culture and analysis facilitated by the CellASIC® ONIX Microfluidic Platform

Abstract Perturbation analysis of live neurons is crucial for fully understanding the nervous system and requires spatiotemporal microenvironment control of cultured neurons. Although advances in microfluidics have enabled such studies, most microfluidic analyses of neurons have required prohibitive...

Robust Differentiation of Human iPSCs into Lineage-Specific Neurons and Glial Cells Utilizing Dual-SMAD Inhibition

Related Products • IPS Cell Culture • Neural Stem Cell Lines • Stem Cell Protocols • 3D Cell Culture • Primary Cell Culture • ECACC Cancer Cell Lines • Cell Culture Media and Reagents • Growth Factors • ECM Protein • Antibodies • Bioactive Small Molecules • CRISPR Genome Editing Introduction Methods...

Neuron Media - Media

Sigma-Aldrich Online Catalog Product List: Neuron Media

Neural Stem Cell Markers and Antibodies

• Neural Stem Cells • Neurons, Astrocytes and Oligodendrocyte Cell Types • NSCs in the Adult Mammalian Brain • Available NSC, Astrocyte, and Oligodendrocyte Marker Antibodies Neural stem cells (NSCs) offer a unique and powerful tool for basic research and regenerative medicine. Changes in the expres...

Nitric Oxide and Cell Stress - Cell Signaling and Neuroscience

Nitric Oxide (NO) is a major signaling molecule in neurons and in the immune system, either acting within the cell in which it is produced or by penetrating cell membranes to affect adjacent cells. Nitric oxide is generated from arginine by the action of nitric oxide synthases (NOS). NO has a half-l...

Serotonin Synthesis and Metabolism

Serotonin (5-hydroxytryptamine) is principally found stored in three main cell types - i) serotonergic neurons in the CNS and in the intestinal myenteric plexus, ii) enterochromaffin cells in the mucosa of the gastrointestinal tract, and iii) in blood platelets. Serotonergic neurons and enterochroma...

Cholecystokinins - Neuropeptides

More recently this hormone has been recognized as a neurohormone, and is secreted by some neurons in the brain. It affects appetite, and may also have roles in anxiety and response to opiates. Cholecystokinin is found in several sizes resulting from proteolytic cleavage of a preprohormone. CCK-33 ...

Vascular Pericytes

Figure 1. Vascular pericyte overview. Pericytes surround blood vessel capillaries and endothelial cells, neurons and astrocytes within the blood-brain-barrier (BBB) neurovascular unit. Pericytes, also known as mural cells, are multipotent perivascular cells that play an important role in the develop...

survival of motor and autonomic neurons 1
Synonyms
Species Human (574013)

ALS, Prion Disease, and Others - ALS, Prion Disease, and others

Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrigs disease and motor neuron disease is characterized by progressive degeneration of upper and lower motor neurons. Although the vast majority of ALS cases are sporadic (SALS), almost 10% appear to be familial (FALS). Studies aiming at findin...

Glutamate/GABA Synthesis and Metabolism

Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. Three such carriers have been cloned and characterized, referred to as ASCT2, GlnT and SN1. They are differential...

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Dopaminergics - Neurotransmitters

The main mechanism responsible for the reinforcing properties of most abused drugs is the direct or indirect activation of dopaminergic neurons in the ventral tegmental area (VTA). This figure represents a dopaminergic neuron in the VTA as well as a GABAergic interneuron and a GABAergic projection n...

13C MRS to Probe Brain Metabolism Using Hyperpolarized Pyruvic Acid

João M. N. Duarte, Ph.D. Laboratory for Functional and Metabolic Imaging Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland Arnaud Comment, Ph.D. Institute of Physics of Biological Systems Ecole Polytechnique Fédérale de Lausanne Lausanne, Switzerland Cerebral function depends on coordin...

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Neural Stem Cell Biology - General Stem Cell Biology

Neural stem cells (NSCs) are generally cultured in vitro as neurospheres, non-adherent spherical clusters of cells, which then can be differentiated into both neurons and glial cells. The products included here are commonly used in NSC research; including media and media reagents and supplements, ne...

Neural Stem Cell Culture

Neural Stem Cell Lines Neural Stem Cell Media and Supplements Neural Stem Cell Markers Stem Cell Culture Protocols Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the basic cell types of the nervous system. NSCs primarily differentiate into neurons, astrocytes, and oligod...

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Astrocytes - Primary Cells

Astrocytes are the most abundant cells in the central nervous system where they perform many functions, such as providing mechanical support and nutrients to neurons and removal of wastes from neurons; providing signaling to endothelial cells; regulating neurogenesis and controlling synaptic functio...

Vasopressin and Oxytocin Receptors

The pituitary hormones arginine vasopressin (AVP) and oxytocin (OT) are structurally related cyclic nonapeptides that act as hormones and neurotransmitters. Both peptides are synthesized in neurons in the hypothalamus that project to the posterior pituitary from which they are released into the circ...

Histamine Synthesis and Metabolism

Histamine is a biogenic amine that stimulates multiple histamine receptor types. In mammals, histamine is found within granules of basophils and mast cells (>90% of body stores) and within tuberomammillary neurons of the CNS. When released, histamine induces complex physiological and pathological ef...

Alpha 2 Adrenoreceptor Modulators

α2-Adrenoceptors are widely distributed and are activated by norepinephrine (A7257, A0937), released from sympathetic nerve terminals or by epinephrine (E4250, E4375), released from the adrenal medulla and from some neurons in the CNS. Perhaps the most extensively characterized action is the prejunc...

Prestige Monoclonals as Neuroscience Markers

• • Download PDF • The nervous system is the system that controls and regulates both voluntary and involuntary processes, and higher-order functions, such as perception, cognition, emotions and others. The principal cells of the nervous system are the neurons, which process and transmit neural signa...

Antibodies to P2X Receptors - Antibodies to Ligand-Gated Ion Channels

P2X receptors are cation-permeable ion channels in the cellular membrane that open in response to the binding of extracellular ATP and some related nucleotides. All P2X receptors (purinoceptors) are permeable to small monovalent cations, and some are permeable to calcium or anions. P2X receptors a...

Galanins - Neuropeptides

Galanin is co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca2+ channels; linked to behavioral and cognitive deficits in Alzheimers disease.

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Mesenchymal Stem Cell Reagents - General Stem Cell Biology

Mesenchymal stem cells (MSC) have the capacity to form different cell types, such as adipocytes, chondrocytes, osteocytes, hepatocytes, cardiomyocytes and neurons, given exposure to different inductive agents. The products included here are commonly used in MSC research, including numerous growth fa...

Antibodies to Nicotinic Acetylcholine Receptors - Antibodies to Ligand-Gated Ion Channels

Nicotine is a chemical with multiple biological and neurological actions. It is a natural alkaloid that mimics the effects of acetylcholine as a neurotransmitter. Nicotinic acetylcholine receptors are cholinergic receptors that activate ligand-gated ion channels in the plasma membranes of certain ne...

Neural Stem Cell FAQs

The use of neural stem cells (NSCs) in biomedical research is becoming increasingly popular, resulting in breakthrough studies rejected the longstanding belief that neuronal tissue is incapable of regeneration. The discovery that neurons, astrocytes, and oligodendrocytes arise from neural stem cells...

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Pharmacologicals - Neurobiology

This diagram represents a sagittal section of the rat brain. Highlighted are the nuclei representing the limbic structures of the basal forebrain including the amygdala, hippocampus, prefrontal cortex (PFC), nucleus accumbens (N. Acc.), ventral pallidum (VP) and ventral tegmental area (VTA). Dopamin...

shRNA Frequently Asked Questions for Advanced RNAi Applications using Difficult Cell Types

How do I know if my cell type can be transduced? Which cell lines or types have been tested? Are MISSION® shRNA viral particles suitable for transduction of neurons? Does direct infusion of positive control viral solution into the mouse brain result in stable GFP expression? I would like to know whe...

Innovative Products and Tools for Neuroscience Research

Driven by a desire to improve human health for all, we are building a network of discovery – creating connections, scientists-to-scientists and sharing insights, ideas and expertise with the goal of advancing neuroscience research. Whether you are developing innovative predictive models, detecting n...

Serotonin Receptors

Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed throughout the mammalian body, being synthesized from L-tryptophan in enterochromaffin cells of the gastro-intestinal tract as well as in serotonergic neurons. The monoamine is a major neurotransmitter in the CNS, but while it is avidly tak...

Neuroscience Resource and Education Center

Learn how we’re working together, scientist-to-scientist, to solve the toughest challenges facing neuroscience. Webinars • Generation and Use of iPSC-derived Microglia to Study Neurodegenerative Diseases • Microglial Activation: Understanding Neuroinflammation's Origins • Neurodegenerative Diseases:...