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Search Results: 1
elastase, neutrophil expressed
Synonyms: ELA2 GE HLE HNE NE PMN-E SCN1
Species: Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), domestic guinea pig Elane (100724414), cow ELANE (100126050), Horse ELANE (100462967), domestic cat ELANE (100301482), dog ELANE (442980)
Gene ID:
Human(1991) elastase, neutrophil expressed
Mouse(50701) elastase, neutrophil expressed
Rat(299606) elastase, neutrophil expressed
sheep(101110841) elastase, neutrophil expressed
domestic guinea pig(100724414) elastase, neutrophil expressed
cow(100126050) elastase, neutrophil expressed
Horse(100462967) elastase, neutrophil expressed
domestic cat(100301482) elastase, neutrophil expressed
dog(442980) elastase, neutrophil expressed
Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]