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Search Results: 1
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Synonyms: MSTP042 NBP1 SFD SFDalpha SFDbeta VMA13
Species: Human ATP6V1H (51606), Mouse Atp6v1h (108664), Rat Atp6v1h (297797), naked mole-rat Atp6v1h (101710987), domestic guinea pig Atp6v1h (100716527), sheep ATP6V1H (101113504), Zebrafish atp6v1h (286779), chicken ATP6V1H (426199), cow ATP6V1H (282657), dog ATP6V1H (486953), domestic cat ATP6V1H (101095225)
Gene ID:
Human(51606) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Mouse(108664) ATPase, H+ transporting, lysosomal V1 subunit H
Rat(297797) ATPase, H+ transporting, lysosomal V1 subunit H
naked mole-rat(101710987) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
domestic guinea pig(100716527) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
sheep(101113504) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Zebrafish(286779) ATPase, H+ transporting, lysosomal, V1 subunit H
chicken(426199) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
cow(282657) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
dog(486953) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
domestic cat(101095225) ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]