Area of Interest
Miscellaneous(1)
Technical Documents(10)
Application
Asymmetric synthesis(5)
Building blocks(2)
Chromatography(2)
Click chemistry(5)
Combinatorial synthesis(2)
Green chemistry(1)
Immobilization(1)
Ligands(5)
Metabolites(2)
Metal organic frameworks(1)
Molecular probes(1)
Positron Emission Tomography(1)
Purification(4)
Solvents(2)
Industry
Pharmaceutical(2)
Polymer science(1)
Process / Function
1,3-Dipolar cycloaddition(11)
Acetylations(1)
Addition reactions(2)
Alkynylations(1)
Castro-Stephens coupling(1)
Catalysis(9)
Chlorinations(2)
Cyclizations(2)
Cycloadditions(11)
Dienylations(1)
Eliminations(1)
Favorskii Reaction(1)
Fluorinations(2)
Huisgen Cycloaddition(1)
Hydroazidations(2)
Hydrosilylations(1)
Metathesis(1)
Nucleophilic additions(1)
Nucleophilic substitutions(1)
Oxidations(3)
Peptide synthesis(2)
Rearrangements(1)
Reductions(2)
Sonogashira Coupling(1)
Staudinger Reaction(1)
Substitutions(1)
Vinylations(1)
Research Area
Chemical biology(1)
Drug discovery(3)
Materials Science(1)
Nanoelectronics(1)
Natural product synthesis(2)

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11 matches found for 1_3_dipolar_cycloaddition

Functionalized Alkynes

ChemFiles 2008, 8.1, 14. Alkynes contain a highly versatile functional group that may be utilized for numerous reactions such as electrophilic additions of hydrogen, halogens, hydrogen halides, or water; metathesis; hydroboration; oxidative cleavage; C–C coupling; and cycloadditions. Terminal alkyne...

Asymmetric Cycloaddition

The asymmetric 1,3-dipolar cycloaddition reaction is of the utmost importance for the enantioselective synthesis of five-membered heterocycles. Cabrera et al. introduced a new family of ligands consisting of a planar chiral P,S-ligand, named Fesulphos, for the 1,3-dipolar cycloaddition of azomethine...

Alkynes

Aldrich ChemFiles 2006, 6.6, 6. Alkynes have been used for many years in the Sonogashira coupling reaction1 and related Castro-Stephens reaction,2 and have recently gained considerable interest in the Huisgen 1,3- dipolar cycloaddition with organic azides.3 Recently, Walsh demonstrated the use of te...

MacMillan Imidazolidinone OrganoCatalysts™ | Product Highlights

Aldrich ChemFiles 2006, 6.2, 9. Product Highlights • Superior enantiocontrol in numerous transformations • High activities at low catalyst loadings • Extraordinary functional group tolerance • Asymmetric α-fluorination employed in natural product synthesis MacMillan and co-workers have created chira...

Azide Building Blocks for Chemical Ligation

Aldrich ChemFiles 2010, 10.2, 6. Dr. Matthias Junkers Dr. Matthias Junkers Product Manager Email: matthias.junkers@sial.com Chemoselective ligation strategies are a key success factor for chemical biology research. Ligation techniques open pathways to fully synthetic large peptides and even proteins...

Copper-Free Click Chemistry

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.1 The absence of exogenous metal catalysts makes these reactions suitable for the in vivo applications of bioorthogonal chemistry ...

Chemical Ligation by Click Chemistry—A “Click” Away from Discovery

The traditional process of drug discovery based on natural secondary metabolites has often been slow, costly, and laborintensive. Even with the advent of combinatorial chemistry and high-throughput screening in the past two decades, the generation of leads is dependent on the reliability of the indi...

Click Chemistry, a newer approach to the synthesis of drug-like molecules

A "Click" Away from Discovery The traditional process of drug discovery based on natural secondary metabolites has often been slow, costly, and labor-intensive. Even with the advent of combinatorial chemistry and high-throughput screening in the past two decades, the generation of leads is dependent...

MacMillan Imidazolidinone OrganoCatalysts™

Product Highlights • Superior enantiocontrol in numerous transformations • High activities at low catalyst loadings • Extraordinary functional group tolerance • Asymmetric α-fluorination employed in natural product synthesis MacMillan and co-workers have created chiral imidazolidinone organo-catalys...

Asymmetric 1,3-dipolar Cycloaddition Using Fesulphos

Aldrich ChemFiles 2008, 8.6, 14. The asymmetric 1,3-dipolar cycloaddition reaction is of the utmost importance for the enantioselective synthesis of five-membered heterocycles. Cabrera et al. introduced a new family of ligands consisting of a planar chiral P,S-ligand, named Fesulphos, for the 1,3-di...

Click Chemistry

Perhaps no reaction in the click family has received more attention than the Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes with organoazides to yield 1,4-disubstituted 1,2,3-triazoles (Scheme 1).1 True to a “good” click reaction, the reaction is reliable and high yielding, ea...