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27 matches found for anticonvulsants

Stem Cell Models for Drug Discovery and Metabolomics Research

Product Manager robert.gates@sial.com Over the past three decades non-cellular and cellular systems have supplanted whole animal studies for the preliminary screening of drug candidates and well as for initial drug metabolism and toxicology studies. In 1991 inadequate metabolic and pharmacokinetic p...

Learning Center - Solid Phase Extraction

• Overview • Applications by Industry • Theory & Method Development • Product Information Environmental Food / Agriculture Pharmaceutical / Biotechnology Natural Products Category / Title Type Size (kb) No. Pages I.D. Environmental Dioxin & PCB Analysis Brochure 2,054 16 JXB The Class-Selective Extr...

Kava (Piper methysticum) | Plant Profiler

Synonyms / Common Names / Related Terms (+) -dihydrokawain-5-ol, 11-methoxy-5, 5-hydroxydihydrokawain, 6-dihydroyangonin, antares, ava, ava pepper, ava pepper shrub, ava root, awa, bornyl cinnamate, cavain, Fijian kava, flavokavines A and B, gea, gi, grog, intoxicating long pepper, intoxicating pepp...

Model Systems for Metabolomics and Drug Toxicity Studies

Robert Gates Robert Gates Product Manager Email: robert.gates@sial.com Over the past three decades non-cellular and cellular systems have supplanted whole animal studies for the preliminary screening of drug candidates and well as for initial drug metabolism and toxicology studies. In 1991 inadequat...

Astec CHIROBIOTIC™ Chiral HPLC Column Literature References

Astec Products | Technical Resources 1. Macrocyclic Antibiotics as a New Class of Chiral Selectors for Liquid Chromatography, D. W. Armstrong, Y. Tang, S. Chen. Y. Zhou, C. Bagwell, J-R. Chen, Analytical Chemistry, Vol. 66, No. 9, 1473-1484 (1994). 2. A Covalently Bonded Teicoplanin Chiral Stationar...

GABAA Receptors

GABAA receptors are responsible for the majority of neuronal inhibition in the mammalian CNS. Agonist activation results in the opening of their integral anion channel, generally leading to hyperpolarization of the cell membrane and thus inhibition. Electron microscopic studies of the native recepto...

Therapeutic Drug Monitoring Standards

Therapeutic drug monitoring (TDM) measures drug concentrations in blood and other biological fluids to ensure maintenance of a drug’s therapeutic range. TDM is performed routinely to guide the dosing regimen for optimizing a drug’s efficacy while minimizing patient toxicity. Using LC-MS/MS or immuno...

Ascentis HPLC Application Notebook Index Alpha

Listing by Phase and Title Return to index selection Phase: C18 C18, LC-MS C8 C8, LC-MS/LC-UV RP-Amide RP-Amide, LC-MS/ LC-UV Ascentis C18 back to top Title Application Report No. Acebutolol and Pindolol Antihypertensives Using Ascentis C18, Analysis of 95 Analgesics Using Ascentis C18, Analysis of ...

Astec Chiral Chromatography Bibliography by Phase

Astec Cellulose Astec CHIRALDEX & Supelco DEX Astec CHIROBIOTIC & Macrocyclic Glycopeptides Astec CLC (Copper Ligand Exchange) Astec CYCLOBOND Astec P-CAP and P-CAP-DP Cyclofructans Copyright restrictions do not permit us to provide copies of the articles listed here. ASTEC Cellulose back to top Sup...

cytochrome P450, family 2, subfamily C, polypeptide 19
Synonyms CPCJ, CYP2C, P450C2C, P450IIC19
Species Human (1557) , Species cow (510380) , Species sheep (100534653)
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Euphorbia (Euphorbia sp) | Plant Profiler

Synonyms / Common Names / Related Terms Amygdaloides latex, asthma spurge, balsam spurge, bisabolane sesquiterpenoid, caper spurge, Christmas flower, dieterpenoids (segetanes, jatrophanes, paralianes), Euphpekinensin, Euphorbia acaulis, Euphorbia alkaloid, Euphorbia antiquorum, Euphorbia balsamifera...

Cat's claw (Uncaria tomentosa) | Plant Profiler

Synonyms / Common Names / Related Terms Ammonia treated quinic acid (QAA), ancajsillo, ancayacu, aublet, auri huasca, bejuco de agua, cat's claw inner bark extract, cell line green Uth-3, C-Med-100®, deixa paraguayo, gambir, garabato, garabato amarillo, garabato blanco, garbato casha, garbato colora...

Astec Chiral Chromatography Bibliography by Subject

Amino Acids, Peptides, Biomolecules Chemical, Environmental, Petrochemical Chiral LC-MS Food, Beverage, Natural Products Mechanistic Studies Pharmaceutical, Clinical Preparative, SFC, SMB Daniel W. Armstrong Publications Copyright restrictions do not permit us to provide copies of the articles liste...

Calamus (Acorus calamus) | Plant Profiler

Synonyms / Common Names / Related Terms α-amophene, α-asarone, α-cadinol, α-cedrene, α-copaene, α-E-bergamotene, α-funebrene, α-humulene, α-muurolene, α-neocallitropsene, α-phellandrene, α-pinene, α-selinene, α-terpineol, α-thujene, Acoraceae (family), acorenone, Acori graminei rhizoma, acorone, Aco...

Lavender (Lavandula angustifolia) | Plant Profiler

Synonyms / Common Names / Related Terms Camphor, common lavender, English lavender, garden lavender, Lavandula angustifolia, Lavandula burnamii, Lavandula dentate, Lavandula dhofarensis, Lavandula latifolia, Lavandula officinalis, Lavandula stoechas, limonene, linalool, linalyl acetate, perillyl alc...

Galanin Receptors

Galanin is a 30 amino acid non-amidated peptide in humans and identified in 14 other species as a 29 amino acid C-terminally amidated peptide. Galanin is widely distributed in both the central and peripheral nervous systems and the endocrine system. Galanin's wide spectrum of biological activities m...

Ascentis Application Index by Compound Class

Listing by compound class Return to index selection HPLC Applications Application Report No. C18 RP-Amide C8 Aromatics 279 140 Artificial Sweeteners 266 Ascorbic Acid 193 Benzoic Acid Derivatives 270 146 Catechols and Resorcinols 141 Drugs of Abuse 336, 337, 338, 339, 340, 341, 342, 343, 344 Estroge...

GABA Transporters

Fast synaptic transmission requires a mechanism for rapid removal of transmitter molecules from the synaptic cleft, a task most often accomplished by transmitter clearance or degradation. High affinity transport proteins fulfill this role for a variety of neurotransmitters including GABA, the major ...

Anticonvulsants Antiepileptics

Sigma-Aldrich's Cerilliant brand offers certified Snap-N-Spike® solutions of second-generation and newer anticonvulsants used in the treatment of fibromyalgia, neuropathic pain, and migraines. These Certified Spiking Solutions® are suitable for numerous applications in pain management or medication ...

Bay leaf (Laurus nobilis) | Plant Profiler

Synonyms / Common Names / Related Terms Alpha-methylene-gamma-butyrolactone moiety, bay laurel, bay tree, costunolide, daphne, dehydrocostus lactone, Grecian laurel, guaianolides, Lauraceae (family), laurel, laurel oil, Laurus, Laurus nobilis L., Mediterranean bay, Mediterranean laurel, noble laurel...

Glutamate Receptors (Ion Channel Family)

The ion channel family of glutamate receptors ("€œionotropic"€ glutamate receptors or iGluR) comprises three major subtypes based on pharmacology and protein structure. The N-methyl-D-aspartate (NMDA) subtype is a hetero-oligomer consisting of an NR1 subunit combined with one or more NR2 (A-D) subu...

Clinical Pharmaceuticals, Illicit Drugs & Alcohol Standards

Update your Panel! Meet our reference materials specialists at Booth 304 at the SOFT 2019 Conference this year in San Antonio, TX on October 13-18 to explore our newest fentanyl CRM offering. We offer a large number of Certified Reference Materials (CRM) and Reference Materials (RM) of numerous phar...

Multi-Component Drug Mix Standards

Sigma-Aldrich's Cerilliant brand offers a wide selection of multi-component drug mix standards for numerous applications including clinical for diagnostic testing, pain monitoring, clinical toxicology, forensic analysis and urine drug testing. Our multi-component drug mixes contain a variety of drug...

Hops (Humulus lupulus) | Plant Profiler

Synonyms / Common Names / Related Terms Colupulone, common hops, European hops, hop, hop strobile, Hopfen (German), houblon (French), humulon, humulus, Humulus lupulus, iso-alpha-acids, lupulin, lupulus, Lupuli strobulus (German), prenylated 2`-hydroxychalcones, prenylflavonoids, spent hops, xanthoh...

Glutamate/GABA Synthesis and Metabolism

Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. Three such carriers have been cloned and characterized, referred to as ASCT2, GlnT and SN1. They are differential...

Medication Monitoring Testing

Prescription monitoring requires accurate reference standards to ensure consistent and reliable results for drug confirmation and monitoring compliance. Sigma-Aldrich's Cerilliant brand offers the widest selection of Certified Spiking Solutions® for prescription monitoring and pain management testin...

Detecting Neural Pathways

Mapping the sensitivity and variability of the brain is crucial for interpreting findings and driving new discoveries in neuroscience research. With innovative technologies in modulation, screening and visualization, scientists can now further their understanding of the brain. This growth of knowled...

Ginseng (Panax ginseng) | Plant Profiler

Synonyms / Common Names / Related Terms Ginseng (American ginseng, Asian ginseng, Chinese ginseng, Korean red ginseng, Panax ginseng:Panaxspp., includingP. ginsengC.C. Meyer andP. quinquefoliusL., excludingEleutherococcus senticosus), Acetylenic alcohol, acidic polysaccharides, acupuncture-moxibusti...