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47 matches found for bioactive_small_molecules

Discover Pfizer Compounds

DISCOVER Pfizer Compounds We understand that in your research, the right tools are essential. Since 2009, we have partnered with Pfizer to provide access to many of Pfizer’s well-studied compounds, making the Pfizer pipeline your pipeline. To further research in drug discovery, over 175 authentic, q...

Receptors and Inhibitors: Scratching the Surface of Bioactive Small Molecules for EGFR Research

Biowire Spring 2011 — Cell Lines — Models of Disease Epidermal growth factor receptor (EGFR) is a principle member of the receptor tyrosine kinases (RTKs) family of cell-surface growthfactor receptors. Its members include EGFR (ErbB1 or HER1; Product Nos. E3641 and E2645), HER2/neu (ErbB2), HER3 (Er...

In Pursuit of the Elements

Making it Easier to Detect Neural Pathways [VIDEO]

Mike Earley, market segment manager for Bioactive Small Molecules and Drugs for MilliporeSigma, discusses the needs neuroscientists have in the modulation and detection of the proteins they are studying, including the ability to understand both the function and the localization of the proteins and t...

SGC Chemical Probes

Chemical Probes from The SGC In your research, it is essential to ensure that your target is the right target. We have partnered with the Structural Genomics Consortium (SGC) to provide highly characterized, novel chemical probes for researching clinically relevant protein targets. These probes, dev...

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparat...

Trending Papers

February 2017 Chimera animals have been created to both study drug effects in humans and also the goal of creating organs for use in humans. A recent breakthrough using CRISPR has occurred to knockout an animal fetus’ immune response to human cells. Now that the human cells can flourish in a non-hum...

Hit Discovery & Confirmation for Early Drug Discovery

Hit discovery and confirmation phase helps in the identification of molecules with activity against the target. This phase needs the development of compound screening assays, depending on the drug target. A hit is a compound which has the desired activity in a compound screen. This activity should b...

Lead Discovery for Early Drug Identification

Using the correct tools can help guarantee that after you’ve identified your novel target, you can create the right key to unlock it. We can support you with the innovation you need to identify, evaluate, and rank new lead candidates in a large screen and then confirm them with secondary assays and ...

Discover Bioactive Small Molecules

DISCOVER Bioactive Small Molecules We understand that in your research, the right tools are essential to ensuring that your target is the right target. With more than 4,000 Bioactive Small Molecules for almost any pathway and all major target classes, we are the premier destination for potent, selec...

Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics. Thus, determining the absorption, distribution, metabolism and excretion properties, as well as the ...

Cancer Research: Products for Angiogenesis, Antitumor agents, Cancer Markers, Carcinogens, and Chemopreventive Agents.

Every detail of your cancer research is vital to the cause, every connection a step forward. Our purpose is to help you solve the toughest problems in life science by providing you with the right reagents, tools and services when you need them. We are committed to helping your discoveries flourish. ...

Neuroscience Events

“Pushing the Frontiers of Neuroscience” was the theme of the 2017 annual meeting of the Japan Neuroscience Society held in July at the Makuhari Messe conference center in Chiba City, Japan. The 40th annual event gathered approximately 3,000 researchers in neuroscience and related fields from across ...

Detecting Neural Pathways

Mapping the sensitivity and variability of the brain is crucial for interpreting findings and driving new discoveries in neuroscience research. With innovative technologies in modulation, screening and visualization, scientists can now further their understanding of the brain. This growth of knowled...

Small Molecule CRISPR Enhancers

As the CRISPR-Cas9 system has become an increasingly popular tool for genome editing, the desire to improve efficiency of precise CRISPR-mediated gene editing has arisen. A number of studies have identified bioactive small molecules that enhance the overall efficiency and targeting precision of CRIS...

Screening Tools To Advance Your Research

From a single biological target to whole genome, transcriptome and proteome studies, we are committed to providing powerful and unique screening tools which fully leverage the discovery potential of our broad range of products. Our portfolio of high-throughput screening tools including the MISSION® ...

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is one of the most important, and complex, systems in the body. The complexity of the nervous system is ...

Advancing Neuroscience Research [VIDEO]

Related Links • Neuroscience • Duolink™ • Bioactive Small Molecules • Antibodies • Biomarker Lead Discovery • Gene Editing Jason Apter, Head of Research Solutions at MilliporeSigma, discusses the company’s approach to neuroscience research. MilliporeSigma is the life science business of Merck KGA, D...

Target Discovery for Early Drug Identification

Is your lab having difficulty discovering novel targets? Our broad portfolio of assays, reagents, and libraries can help you find the right lock so you can begin the work to unlock it. From the Sanger Whole Genome CRISPR Library to Duolink® PLA to measure protein-protein interactions, and bioactive ...

High Throughput Screening

As a leading supplier of products and services to the drug discovery research community, we provide a broad spectrum of products to aid high throughput screening. The high purity screening compounds are specifically selected to maximize chemical diversity while maintaining drug-likeness to aid the g...

LOPAC1280 – Library of Pharmacologically Active Compounds

LOPAC®1280 – The Library of Pharmacologically Active Compounds The power and performance of the bioactive small molecules in our Library of Pharmacologically Active Compounds (LOPAC1280) is assured. This biologically annotated collection of inhibitors, receptor ligands, pharma-developed tools, and a...

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number o...

Innovative Products & Tools for Cancer Research

We are committed to help predict cancer with novel discovery tools, characterize cancer with proven platforms, and drive cancer therapeutics through approval and production. As a company with a robust cancer research division, we know what works. Researchers are stronger in the fight with an oncolog...

National Eye Institute: 3-D Retina Organoid Challenge

The National Eye Institute is sponsoring a challenge to spur development of a robust 3-D retina organoid system for modeling retina diseases and testing new therapies. With up to a $1M in prizes to be awarded, it is an exciting opportunity for neuroscience researchers. Learn more about 3DROC. As a l...

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activity, subcellular localization, association or binding properties of a protein or lipid. Phosphorylatio...

Pharmaceutical Drugs and Drug Candidates

BioFiles Volume 7, Number 5 — Pharmaceutical Drugs and Drug Candidates Download BioFiles v7 n5 (3.18 Mb PDF) Table of Contents • Antihypertensive Agents ○ Angiotensin-Converting Enzyme (ACE) Inhibitors ○ Angiotensin II Receptor Blockers (ARBs) ○ α1-Adrenoreceptor Blockers ○ β-Adrenergic Blockers ○ C...

Trifunctional Probe Building Blocks

Related Articles • Chemical Synthesis Technology Spotlights Chemical probes that mimic a pharmacophore, ligand, or lead compound are of increasing interest for target identification and validation, protein profiling, imaging, or other applications in chemical biology. However, synthesis of the ideal...

Small molecules for early Drug Identification

Let our robust portfolio of early drug identification assays and reagents provide you the key to success your research requires to unlock the next generation of new molecular entities and drug candidates. Our expertise in the pharmaceutical industry allows us to provide the cutting-edge innovation y...

Discover Bristol-Myers Squibb Compounds

DISCOVER Bristol-Myers Squibb Compounds We understand that in your research, the right tools are essential. Our commitment to providing researchers with the broadest selection of reliable, quality-controlled tools has resulted in a partnership with Bristol-Myers Squibb to provide access to authentic...

Target Identification & Validation for Early Drug Discovery

Early stages of drug discovery start with initial steps of target identification and moves to the later stages of lead optimization. Multiple sources including academic research, clinical works and commercial sector help in the identification of a suitable disease target. The chosen target is then u...

Innovative Products and Tools for Neuroscience Research

Driven by a desire to improve human health for all, we are building a network of discovery – creating connections, scientists-to-scientists and sharing insights, ideas and expertise with the goal of advancing neuroscience research. Whether you are developing innovative predictive models, detecting n...