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cataCXium® - Ligands and Complexes for Efficient Cross-Coupling Reactions

. Introduction . Advantages . Representative Application . Materials List Cross-coupling reactions are an important class of catalytic transformations with applications in polymer science as well as in the fine chemicals and pharmaceutical industries. The use of aryl chlorides for these transformati...

catASium - Advantages & Applications

. Introduction . Advantages . Representative Application . Materials List Cross-coupling reactions are an important class of catalytic transformations with applications in polymer science as well as in the fine chemicals and pharmaceutical industries. The use of aryl chlorides for these transformati...

LC/MS/MS Analysis of Aflatoxins in Hops After Solid Phase Extraction Cleanup

Related Products • Food & Beverage Analysis • Toxins (other than pesticide/drug residues) • Supel™ Tox SPE Cartridges Related Articles • Reporter US Volume 34.1 • Analysis of Residual Solvents in Hemp Extract by Headspace SPME-GC/MS • Headspace SPME GC/MS Analysis of Terpenes in Cannabis • Quantifyi...

Psyllium (Plantago ovata) | Plant Profiler

Synonyms / Common Names / Related Terms Arabinose, Bran Buds® cereal, bulk laxative, Effersyllium®, fiber, Fiberall®, Fiber-loop cereal, flea seed, fleawort, Fybogel®, Heartwise® cereal, hemicellulose, Hydrocil®, Indian plantago seed, isabgol, I-so-gel®, ispaggol, ispaghula, ispaghula husk, ispaghul...

Polypodium lepidopteris (Polypodium leucotomos extract and anapsos) | Plant Profiler

Synonyms / Common Names / Related Terms Calaguala, ferns, Polypodiaceae (family), Polypodium cambricum, Polypdium decumanum, Polypodium vulgare, samambaia. Mechanism of Action Pharmacology: • In vitro and animal research of Polypodium leucotomos extract (anapsos) has reported cardiovascular effects8...

Goldenrod (Solidago virgaurea) | Plant Profiler

Synonyms / Common Names / Related Terms Aaron's rod, acetylene, astragalin, beta-amyrin acetate, beta-dictyopterol, blue mountain tea, Canadian goldenrod, cinnamate, clerdane diterpene, early goldenrod, echte guldenroede (Dutch), elongatolide C, elongatolide E, European goldenrod, flavonoid, golden ...

Linking Biological Molecules to Highly Potent APIs

Melissa Jacobs, Director, Global Marketing Communications View the PDF Medical researchers are arming themselves with a new series of weapons in the war against disease – conjugated drugs that link biological molecules to a highly potent active pharmaceutical ingredient (HPAPIs). “These bio-conjugat...

Diverse CD4 Response to Vaccinia Virus in Human is Revealed by Proteome-Wide T cell Profiling

• • Download PDF • Authors: Lichen Jing,1 D. Huw Davies,2 Tiana M. Chong,3 Sookhee Chun,2 Christopher L. McClurkan,3 Jay Huang,3 Brian T. Story,3 Douglas M. Molina,4 Siddiqua Hirst,2 Philip L. Felgner,2 and David M. Koelle1,2,5,6,7*, Department of Medicine, University of Washington, Seattle, Washing...

Autophagy and Mitophagy in Tumor Cell Survival and Death

Autophagy is a highly regulated process that is involved in cell growth, development, and death. In autophagy cells destroy their own cytoplasmic components in a very systematic manner and recycle them. In mammalian cells, autophagy occurs constitutively at basal rates and its primary function is to...

deleted in liver cancer 1
Synonyms ARHGAP7, HP, STARD12, p122-RhoGAP
Species Human (10395) , Species Mouse (50768) , Species Rat (58834) , Species chicken (422740) , Species dog (475607) , Species domestic cat (101086801) , Species Horse (100052317) , Species cow (511433) , Species sheep (101123183) , Species Domestic Rabbit (100352546) , Species domestic guinea pig (100729904) , Species naked mole-rat (101714040)
Summary: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

Chitosan: A Versatile Platform for Pharmaceutical Applications

Raphael Riva and Christine Jerome* Center for Education and Research on Macromolecules University of Liege, Chemistry Department, Sart-Tilman, Building B6a, 4000 Liege, Belgium *Email: c.jerome@ulg.ac.be The development of new medical devices and pharmaceuticals plays an integral role in the medical...

Hybridoma Fusion Partners Cell Lines

Hybridoma technology involves the production of monoclonal antibodies specific to an antigen of interest. The somatic fusion of B lymphocytes of the spleen with immortal myeloma cells gives rise to a hybridoma cell line that can be perpetually propagated to produce clonally identical antibodies, as ...

Heck Reaction

The Heck reaction is the palladium catalyzed cross-coupling reaction between alkenes, and aryl or vinyl halides (or triflates) to afford substituted alkenes.1,2 It is a useful carbon–carbon bond forming reaction with synthetic importance. The reaction proceeds in the presence of base and it is highl...

Propolis (Propolis) | Plant Profiler

Synonyms / Common Names / Related Terms Apis mellifera L., bee glue, bee propolis, bee putty, Bienenharz (German), Brazilian green propolis, Brazilian propolis, Bulgarian propolis, caffeic acid phenethyl ester, CAPE, cera alba, chizukit, cinnamic acid, flavonoids, galangin, Greek propolis, hive dros...

Chickweed (Stellaria media) | Plant Profiler

Synonyms / Common Names / Related Terms Borneol, Caryophyllaceae (family), common chickweed, linalool, menthol, Stellaria holostea, Stellaria longipes, Stellaria media, Stellaria media Cyrill., Stellaria media Villars, terpenes. Mechanism of Action Pharmacology: • Constituents: The following constit...

AvaBridge ELISA Kit Protocol

Product Number. ABK0001 Complete kit for the systematic 3-D conformational comparability analysis of Avastin biosimilar molecule to Bevacizumab (Avastin trade name). Read the entire protocol before performing the assay. This kit is intended for research use only and not for use in diagnostic procedu...

Air Monitoring Paints & Coatings - Pigments

Paint pigments have been around since prehistoric early artwork and have evolved to what they are today. Pigments come in a variety of types from those that are naturally occurring mineral-based (iron oxide, clay-based, carbon black, zinc, etc) to the synthesized pigments of today. The earliest synt...

EGF/EGFR signaling pathway

Background Epidermal Growth Factor Receptors (EGFR) and ligands Receptor activation EGFR Signaling Ras/Raf signaling cascade Phosphatidylinositol 3-kinase/Akt signaling cascade Signal transducers and activators of transcription (STAT) pathway Phospholipase Cγ signaling Nck/PAK signaling cascade Cbl ...

Cultrex® 3-D Culture Matrix™ Laminin I Protocol

Product Number 3446-005-01 3D Culture is a cell culture method that provides cells with the necessary structure and signaling cues to direct reconstruction of the tissue architecture, and these methods provide physiologically predictive in vitro models for evaluating development and disease. Normal ...

Adenosine Receptors

Adenosine receptors are members of the superfamily of G protein-coupled receptors and each bears the characteristic motif of seven transmembrane spanning domains. They fall into four known subtypes, referred to as A1, A2A, A2B and A3. Adenosine Receptors in Disease Research Modulation of adenosine r...

Apoptosis | BioFiles Volume 5, Number 8 - Cell-Based Assays

BioFiles Volume 5, Number 8 — Cell-Based Assays Download BioFiles v5 n8 (3.9 Mb PDF) Table of Contents • Introduction • Assays and Reagents for Measuring Cytotoxicity, Proliferation, and Viability • Apoptosis • Autophagy • Reactive Oxygen Species Enzymes Kits • LOPAC® Library • Cell and Organelle La...

Methods of Quantification

Standard Curves Standard curves are necessary for both absolute and relative quantification. When generating standard curves, different concentrations of DNA (typically five) should be used to generate a standard curve that will bracket the concentration of the unknown. Each concentration should be ...

Neurotensin Receptors

Neurotensin is a 13 amino acid regulatory peptide found mainly in gut and brain. Intestinal neurotensin is produced by a discrete population of endocrine cells (N cells) scattered throughout the jejuno-ileal mucosa. The peptide is released into the circulation after food ingestion. Its digestive fun...

Qualitative Multiplex PCR Assay for Assessing DNA Quality from FFPE Tissues and Sources of Damaged DNA

• • Download PDF • The assessment of DNA quality is a crucial first step in acquiring meaningful data from formalin-fixed paraffin-embedded (FFPE) tissues, and other sources of damaged DNA. Using intact genomic DNA is key for successful analysis of chromosomal aberrations (e.g. SNP analysis, LOH, aC...

Burdock (Arctium lappa) | Plant Profiler

Synonyms / Common Names / Related Terms Akujitsu, anthraxivore, arctii, arctiin, arctigenin, arctiol, Arctium lappa Linne, Arctium minus, Arctium tomentosa, Arctium tomentosum Mill., Asteraceae (family), bardana, Bardanae Radix, bardane, bardane grande (French), beggar's buttons, burdock root, burr,...

In Vitro Transporter Models for ADME-Tox Research Webinar

Drug transporters play a pivotal role in mediating the disposition of many drugs. As a result, researchers in the fields of drug discovery and development have shown a steadily rising level of interest in transporter-drug interactions, transporter-mediated drug-drug interactions, and the role of tra...

MISSION™ shRNA Library: Next Generation RNAi

By Stephanie Uder, Henry George, and Betsy Boedeker Sigma-Aldrich Corporation, St. Louis, MO, USA Introduction The technology of RNA interference emerged in its earliest form following a 1998 study in Caenorhabditis elegans1and has since rapidly evolved to its current form as a revolutionary tool fo...

The Role of Liver Transporters in Drug-Drug Interactions

• Oral drug delivery involves dissolution in the small intestine and absorption across the enterocyte barrier into the portal vein followed by subsequent delivery through the liver into the systemic circulation. The liver therefore plays a vital role in all aspects of drug disposition, including abs...

Ginger (Zingiber officinale) | Plant Profiler

Synonyms / Common Names / Related Terms African ginger, Amomum zingiber L., black ginger, bordia, chayenne ginger, cochin ginger, curcumin, EV.EXT35, gan jiang, gegibre, gingembre, ginger BP, ginger oil, ginger power BP, ginger root, ginger trips, gingerall, gingerly, gingerols, ingwer, Jamaica ging...

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic s...

Transplex® RNA Amplification Kit: Whole Transcriptome Amplification of Highly-Degraded RNA from FFPE Tissues.

Ken Heuermann and Brian Ward Research and Development, Biotechnology Division, Sigma-Aldrich The TransPlex Complete Whole Transcriptome Amplification (WTA2 ) Kit effectively amplifies intact and highly degraded RNA. To benchmark maintenance of representative RNA levels during amplification, differen...