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31 matches found for chemical_biology

Product Highlights for Organic and Inorganic Synthesis Archive

By Application Area Cross-Coupling • Bis-Hydroxamic Acid (BHA) Ligands – New Chiral Ligands for Asymmetric Oxidation (2009) • BRIDP from Takasago - New Ligands for Cross-Coupling Catalysis (2008) • MIDA Boronates (2008) • Symphos Ligands for Efficient Suzuki Cross-Coupling (2008) • cataCXium®—Ligand...

Bioconjugation

Bioconjugation involves ligating molecules together in which at least one of the reactants is a biomolecule, often an antibody, protein, or oligonucleotide. Applications include attaching fluorescent probes to antibodies for flow cytometry and microscopy imaging, attaching antibodies to beads for im...

Professor Product Portal - Andrew Wilson Group

Related Links • VIEW PRODUCT LIST • Professor Product Portal • Organic Synthetic Chemistry Professor Product Portal Index Professor Andrew Wilson The Wilson group use innovative synthetic methods to develop small molecule mimics and probes of biomacromolecule structure and function. A particular foc...

New Building Blocks for Chemical Biology

Matthias Junkers, Ph.D. Product Manager matthias.junkers@sial.com Modern automated synthesis protocols allow the fast and effi cient production of biopolymers like peptides and even proteins, or oligonucleotides. In recent years, even the automated synthesis of complex carbohydrates has been describ...

Antonio Togni - Professor Product Portal

Professor Product Portal Index Professor Antonio Togni Research in the Togni group focuses on the development of new ligands and reagents. These two general directions thus impact the ability to construct molecules in more efficient or unprecedented ways. In the field of homogeneous catalysis, our g...

Biology and Analytical Chemistry Webinar Guide

Biology Webinar Guide Quality Systems and Regulatory Compliance Drug Discovery Webinar Guide Analytical Webinar Guide Materials Science Webinar Guide • Proteomics • qPCR • CRISPR • Cell Culture • Cell Design Studio • Duolink • RNAi • Regulatory Compliance • Late Stage Functionalization of Drug-Like ...

Small Molecule CRISPR Enhancers

As the CRISPR-Cas9 system has become an increasingly popular tool for genome editing, the desire to improve efficiency of precise CRISPR-mediated gene editing has arisen. A number of studies have identified bioactive small molecules that enhance the overall efficiency and targeting precision of CRIS...

Unsaturated Amino Acids

Recent developments in Chemical Biology research have increased the demand of amino acid building blocks with unsaturated side chains. Alkyne moieties can be used in bioorthogonal synthesis strategies to form hybrid structures, introduce chemical probes into biomolecules, or link large fragments wit...

Detection, quantification and visualisation of protein interactions for hit profiling by high content screening

Alongside established drug target classes, innovative approaches are addressing previously undruggable target classes such as protein–protein interactions. Protein interactions and their relocation within the cell have traditionally been studied using an over-expressed cell model or cell lysate meas...

Small Molecule Probes and Inhibitors Series

Small Molecule Probes and Inhibitors Series • Navigating the Promise and Perils of Chemical Probes through Community-Driven Expertise • Sulfonyl Fluorides in Chemical Biology and Drug Discovery Webinar Chemical probes are powerful reagents with increasing impacts on biomedical research. However, pro...

AISF: A Stable, Solid Alternative to Sulfuryl Fluoride Gas

Related Links • Chemical Synthesis Technology Spotlight • Professor Product Portal Fluorosulfates and sulfamoyl fluorides have applications ranging from chemical biology to polymer chemistry in addition to being valuable synthetic precursors to diaryl sulfates, sulfamides and sulfamates. Synthetic m...

Dennis Hall - Professor Product Portal

Professor Product Portal Index Professor Dennis Hall Research in the Hall Group is centered on organoboron chemistry and explores various applications of boronic acid derivatives in reaction development, catalysis, natural product synthesis, and chemical biology. Hall and his co-workers have pioneer...

Read the latest developments in CRISPR research

read abstract Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes Adriana CarolinaGonzalez1MichaelaSchweizer2SebastianJagdmann1ChristianBernreuther3ThomasReinheckel4PaulSaftig1MarkusDamme15 23-01-2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late...

Product Directory Home

Analytical / Chromatography • Analytical Standards • Applications • Derivatization Reagents • Gas Chromatography • HPLC • LPLC/TLC/Paper Chromatography • Microbiology • Resins & Media • Sample Prep/Purification • Solid Phase Microextraction • Syringes • Titration • Vials • More.. Materials Science •...

Chemical Biology

The Chemical Biology product line incorporates techniques and strengths of chemistry to address fundamentally important questions in biology, medicine, and drug discovery. With chemical biology products from Sigma-Aldrich portfolio, you have solutions, expertise and industry leadership to help advan...

Chemistry

By partnering with the brightest minds in chemistry, we bridge the gap between the lab and the market for innovators and practitioners. We have a new name and look but the same quality organic and inorganic chemicals for chemical synthesis, medicinal chemistry, and many other applications. Easily fi...

Azide Building Blocks for Chemical Ligation

Dr. Matthias Junkers, Product Manager Chemoselective ligation strategies are a key success factor for chemical biology research. Ligation techniques open pathways to fully synthetic large peptides and even proteins. They have proven to be valuable for peptide cyclization. Beside peptide synthesis, c...

Raines Group – Products available at Aldrich from the Raines Laboratory

Related Links • VIEW PRODUCT LIST • Professor Product Portal • Organic Synthetic Chemistry • Chemical Biology Professor Product Portal Index Professor Ronald Raines Professor Ron Raines works with Sigma-Aldrich on the development of reagents and tools for chemical biology such as the traceless Staud...

Trifunctional Probe Building Blocks

Related Articles • Chemical Synthesis Technology Spotlights Chemical probes that mimic a pharmacophore, ligand, or lead compound are of increasing interest for target identification and validation, protein profiling, imaging, or other applications in chemical biology. However, synthesis of the ideal...

Lysophospholipid Receptors

Although historically considered as intermediates in the biosynthesis of glycerophospholipids and the degradation of sphingolipids, the lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) together form a class of extracellular mediators that evoke a wide range of biologic...

Professor Product Portal

The Professor Product Portal highlights the partnership between Sigma-Aldrich and academic investigators to commercialize research discoveries. It is our commitment to provide solutions for our customers by ensuring the rapid availability of cutting-edge catalysts, building blocks, and reagents from...

Product Highlights for Organic and Inorganic Synthesis

NEW! Fragment-Based DNA-Encoded Library for Drug Discovery NEW! Pym-DATB: Highly Efficient Amidation Catalyst NEW! Ketosulfoxonium Ylides: Safe, Versatile Carbene Equivalents NEW! MCAT- 53™ Catalyst for Ruthenium Formation NEW! Photocatalysis NEW! Partial PROTACs for Targeted Protein Degradation NEW...

Lipopolysaccharides - Structure, Function and Application

Glycobiology Analysis Manual Table of Contents Lyophililized Powders Detoxified Lipopolysaccharides Ready Made Solutions Lipopolysaccharide (LPS) is the major component of the outer membrane of Gram-negative bacteria. Lipopolysaccharide is localized in the outer layer of the membrane and is, in nonc...

Staudinger Ligation - Technology Spotlights

A High-Yield, Chemoselective, and Mild Synthetic Method Azides react readily with triarylphosphines to form the corresponding iminophophoranes (aza-ylides) with loss of nitrogen. This transformation, originally reported by Staudinger and Meyer,1 takes place under mild conditions and leads to excelle...

Helen Blackwell Group - Professor Product Portal

Professor Product Portal Index Professor Helen E. Blackwell Our laboratory pursues research at the chemistry-microbiology interface. We are deeply interested in the mechanisms by which bacteria sense each other, their environment, and the eukaryotic hosts on which and in which they may reside. One p...

Ben Cravatt Group – Professor Product Portal

Related Links • VIEW PRODUCT LIST • Professor Product Portal • Chemical Biology • Organic Synthetic Chemistry Professor Product Portal Index Professor Ben Cravatt The aim of the Cravatt research group is to understand the roles that mammalian enzymes play in physiological and pathological processes ...

SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction

Sulfur (VI) fluoride exchange (SuFEx) has been identified as the next click chemistry reaction owing to the balanced properties of fluoride bonding to hydrogen and sulfur (VI). In collaboration with K. Barry Sharpless, we now offer a variety of sulfonyl fluoride reagents that undergo a newly defined...

Inverse Electron Demand Diels–Alder Reactions of 1,2,4,5-Tetrazines and 1,2,3-Triazines

The inverse electron demand Diels-Alder reactions of electron-deficient heterocycles are significant cycloaddition reactions for the total synthesis of natural products containing highly substituted and functionalized heteroaromatic ring systems. In collaboration with Professor Dale Boger, we are pl...

ChemFiles

ChemFiles is a FREE quarterly newsletter written by our experts from Product Management and R&D, highlighting our latest innovative products from: Building Blocks, Synthetic Reagents, Asymmetric Synthesis, Catalysis and Inorganic Reagents, Organometallic Reagents, Chemical Biology, Specialty Synthes...

Diversinates™: Linkers for Native Chemical Tagging of C–H Bonds

Bioconjugation is an essential concept in chemical biology wherein a biomolecule is covalently bound to another biomolecule, a fluorescent dye, a cytotoxic payload (drug), and other bioactive or labeling compounds. To incorporate a small molecule drug into a biomolecule, one often requires reactive ...