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577 matches found for clinical

Reaching the “Peak” of Recovery: Improving Antibody Separations with the Inclusion of Organic Alcohols

Related Articles • Reporter US Volume 34.4 • Robustness of the Discovery® HS F5 HPLC Column in the Study of Metabolomics • Rapid Determination of Protein Binding Affinity Using Solid Phase Microextraction • Analysis of Human Plasma Lipids Using sub-2 μm C18 UHPLC Column with MS Detection • Analysis ...

Stem Cell Biology — Where We’ve Been and Where We’re Heading

BioFiles 2008, 3.11, 4. Dr. Greg Wall, Ph.D. Unraveling and exploring the mysteries of life have been driving forces behind scientific studies since Aristotle first attempted to understand the origins of life. Through the eyes of the microscope, cellular processes have been observed, investigated, u...

Ultrapure Water for LC-MS Biomedical Analyses

In this paper the suitability of reagent water for LC-MS biomedical analyses will be evaluated and the role of water quality in achieving sensitive and reliable LC-MS analyses will be discussed. Furthermore, since quality assurance is one of the key requirements in the clinical laboratory, a modern ...

Introduction | BioFiles Volume 5, Number 2 Protein Characterization & Detection

BioFiles Volume 5, Number 2 — Protein Characterization & Detection Download Biofiles v5 n2 (3.4 Mb PDF) Table of Contents • Introduction • Labeling of Proteins • X-ray Crystallography/Crystallization • MALDI Mass Spectrometry • Colorimetric Electrophoresis Stains • IEF Focusing • Western Blotting • ...

Stem Cell Models for Drug Discovery and Metabolomics Research

Product Manager robert.gates@sial.com Over the past three decades non-cellular and cellular systems have supplanted whole animal studies for the preliminary screening of drug candidates and well as for initial drug metabolism and toxicology studies. In 1991 inadequate metabolic and pharmacokinetic p...

Cannabinoid Standards

Cannabinoids are a class of psychoactive substances that are among the most widely abused and readily available drugs in the world.1,2 These drugs can produce intense psychological and physiological effects including auditory and visual hallucinations, anxiety, and euphoria. Besides persistent illic...

Immunohistochemistry: Current Applications in Breast Cancer

By: Mike Lacey, M.D. Recorded Webinar Immunohistochemistry (IHC) is used to characterize intracellular proteins or various cell surfaces in all tissues. Individual markers, or more often panels of various marker proteins, can be used to characterize various tumor subtypes, confirm tissue of origin, ...

Working with BRAND® Liquid Handling Instruments

The ever increasing demands on the quality of analytical results, and the growing number of samples to be processed result in a need for volumetric instruments which help to handle the routine work in sample preparation as efficiently as possible. Manufacturers of laboratory equipment have responded...

Human Protein Atlas Webinar

A Human Protein Atlas Mathias Uhlen, AlbaNOva University Center, Royal Institute of Technology, Stockholm, Sweden The completion of the human genome sequence has opened up a possibility for global expression profiling of human tissues and cells, allowing for comparative studies between normal and di...

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Immunohistochemistry: Current Applications in Gastrointestinal Cancer

Incidence Deaths Lifetime risk of Colorectal Cancer Signs and Symptoms Immunohistochemistry and Colon Cancer Metastatic Carcinoma [Webinar] Colorectal Cancer and Immunohistochemistry Materials References Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 ca...

Ultrafiltration in protein sample preparation

On this page: • What is ultrafiltration? • Ultrafiltration vs dialysis • Ultrafiltration vs Microfiltration Membranes • How to use ultrafiltration in your lab What is ultrafiltration? Ultrafiltration (UF) is the process of separating extremely small particles and dissolved molecules from fluids. The...

The Definitive Guide to Cannabis Testing

The cannabinoids found in the Cannabis plant, commonly referred to as marijuana, have grown in popularity for treating a variety of ailments from arthritis, glaucoma and chronic pain to malnutrition, multiple sclerosis and cancer.1 Whether smoked, consumed in food, applied as a cosmetic, or concentr...

Water for Next-Generation Sequencing

Water is used throughout the next-generation sequencing (NGS) workflow, from DNA fragmentation to sequencing runs and instrument cleaning. Using the appropriate water quality for each step will not only eliminate the risk of water contaminants interfering with nucleic acids and the many enzymatic re...

Solubility enhancement using PEG-polyester diblock copolymers for drug delivery

One of the common difficulties with intravenous drug delivery is low solubility of the drug. The requirement for large quantities of saline to dissolve such materials limits their clinical use, and one solution for this problem that has recently generated interest is the formation of drug-loaded mic...

Yersinia Diagnostic

Ivo Siegrist, Product Manager Microbiology ivo.siegrist@sial.com Yersinia are rod-shaped, Gram-negative facultative anaerobic bacteria. They exhibit fermentative metabolism and are oxidasenegative, mannitol-positive. A psychrophilic organism, Yersinia survives and proliferates at low temperatures of...

Further Applications of Ficoll-Paque PLUS and Ficoll-Paque PREMIUM

Extracted from Isolation of Mononuclear Cells, Methodology and applications (PDF) GE Healthcare, 2010 A great many modifications and extensions of the method have come into use following the introduction of the technique described by Bøyum in 1968 and its subsequent widespread adoption. For example,...

Complete Solutions for IVD Lateral Flow Immunoassay Development

Simplify immunoassay development and manufacture with a partner who understands the IVD market Accelerate your time to market with fit-for-use products which offer the quality, consistency, and documentation necessary for every step of your IVD development and manufacturing needs. Proven expertise i...

Analytical Enzyme Factor Xa

On this page: • Products • Physical Properties and In Vivo Processing • Specificity, Assay and Kinetics • Inhibitors • Substrates • Solubility and Solution Stability • Applications and Clinical Implications Physical properties and in vivo processing Factor Xa is a serine endoproteinase and a member ...

Bioactive Small Molecules Literature References

Cell Biology Applications Center Bioactive Small Molecules Literature References Looking for current application references for Bioactive Small Molecules? Look no further! • Apoptosis • Kinase Phosphatase Biology • Neuroscience Apoptosis Publications: Click on the title to view the abstract on PubMe...

Human Protein Atlas

The Human Protein Atlas was initiated in 2003 with the aim of mapping all human proteins within cells, tissues and organs and providing this information in an open-access format to advance understanding of human biology and disease. Divided into three sub-atlases – the Tissue Atlas, Cell Atlas and P...

Cell Division Monitoring using Cell Tracking Dyes [VIDEO]

Fluorescent cell tracking dyes, in combination with flow and image cytometry, are powerful tools with which to study the interactions and fates of different cell types in vitro and in vivo.1-5 Although there are literally thousands of publications using such dyes, some of the most commonly encounter...

5 Reasons Cancer Researchers Adopt 3D Cell Culture: A Review of Recent Literature

Summary Introduction Growing Cells in 3D alters proliferation and cell morphology Growing cells in 3D reveals a more realistic drug response Growing cells in 3D captures phenotypic heterogeneity Growing cells in 3D changes gene expression and cell behavior Growing cells in 3D mimics the tumor microe...

How to Select the Right Water Purification System for Your Lab

Related Products • Milli-Q® IQ 7003/05/10/15 Type-1 & Type-2 Water • Milli-Q® IQ 7000 Type-1 Water • Milli-Q® Advantage • Elix® Advantage • Milli-Q® HX 7000 Series Type-2 High-Throughput Water • Milli-Q® CLX 7000 Connected High-Throughput for Clinical Analyzers • SDS 500 - Water Storage, Protection ...

Cardiac Drugs

Worldwide cardiovascular disease (CVD) prevalence is increasing, with countries such as China projecting a 73% increase in their CVD rates by 20301 and England projecting a 15% increase by 2020.2 Nearly all cardiac drugs have a narrow therapeutic range requiring careful therapeutic drug monitoring (...

ISO 13485 vs. ISO 9001

Misunderstandings about International Organization for Standardization (ISO) management standard 13485, and how it compares to other industry standards such as ISO 9001 or Current Good Manufacturing Practice (cGMP), are common. Here, Narayan Krishnaswami, Senior Global Marketing Manager in the Appli...

Pimary-Cancer-Cell-Media

Tumors consist of a heterogeneous mixture of multiple interacting cell types including non-tumorigenic and malignant phenotypes such as tumor cells, cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs) and stromal cells. Only a small subpopulation are cancer cells capable of dri...

Biomarkers for Neuroscience Research

Understanding and treating neurological diseases is a major challenge due to the complexity and dynamic environment of the central nervous system (CNS). Fortunately, with the use of neuroscience biomarkers these complexities start to unfold and come to life. Biomarkers are essential indicators of ne...

Water Purification System Consumables

Related Links • Milli-Q® IQ 7003/7005 Ultrapure & Pure Water Purification System • Water Purification Solutions • Milli-Q® Integral • Milli-Q® IQ 7000 Type-1 Water • Milli-Q® Advantage • Elix® Advantage • Elix® High-Throughput for Type 2 Water • Milli-Q® CLX 7000 Series of High Throughput for Clinic...

Robust, load independent viral clearance in monoclonal antibody purification with NatriFlo® HD-Q membrane adsorber

Anion exchange chromatography is an important flowthrough polishing step for viral clearance of monoclonal antibodies (mAbs). Resin based materials are most commonly used for this but the large size of virus particles limits diffusion and binding capacity. It is therefore necessary to use large volu...

Water for Clinical Chemistry

In the clinical laboratory, water is a key factor. There are two significant reasons for the importance of water in the clinical setting: the need to comply with norms or guidelines (e.g., those of the Clinical and Laboratory Standards Institute® – CLSI®)1 and the sensitivity of the chemistries them...