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    Search term:"degradations"

    417 matches found for degradations

    Beta Amino Acids

    Although they are less abundant than their α-analogues, β-amino acids occur in nature both in free form and bound to peptides. Oligomers composed exclusively of β-amino acids (so-called β-peptides) might be the most thoroughly investigated peptidomimetics. Besides being remarkably stable to metaboli...

    What is Hyaluronan?

    • Brief Summary • Nomenclature • Chemistry and Physical Properties • Biological Roles • Degradation of Hyaluronan • Hyaluronan Synthesis • Glycosil vs. Unmodified HA • History of Hyaluronan • References Brief Summary Hyaluronic acid (HA) is the simplest glycosaminoglycan (a class of negatively charg...

    Biomolecular NMR: Isotope Labeling Methods for Protein Dynamics Studies

    • • Download PDF • Protein structure determination by solution NMR spectroscopy has long relied on the uniform stable isotopic enrichment with 13C and 15N to alleviate resonance overlap and to allow multiple distance and angular restraints, at as many atomic sites as possible, to facilitate computin...

    Parkinson's Disease

    Download BioFiles v7 n2 (13.0 Mb PDF) Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting more than 6 million people worldwide. PD is a slowly progressing motor system neurodegeneration characterized by akinesia, rigidity and resting tre...

    Molybdenum Disulfide: Understanding Hydrogen Evolution Catalysis

    Linyou Cao Department of Materials Science and Engineering Department of Physics North Carolina State University, Raleigh, NC, USA Email: lcao2@ncsu.edu The production of hydrogen by catalytic water splitting is important for a wide range of industries including renewable energy petroleum refining a...

    Autophagy and Mitophagy in Tumor Cell Survival and Death

    Autophagy is a highly regulated process that is involved in cell growth, development, and death. In autophagy cells destroy their own cytoplasmic components in a very systematic manner and recycle them. In mammalian cells, autophagy occurs constitutively at basal rates and its primary function is to...

    Bioactive Small Molecules Literature References

    Cell Biology Applications Center Bioactive Small Molecules Literature References Looking for current application references for Bioactive Small Molecules? Look no further! • Apoptosis • Kinase Phosphatase Biology • Neuroscience Apoptosis Publications: Click on the title to view the abstract on PubMe...

    Sialic Acid Synthesis and Signaling | BioFiles Volume 5, Number 1 Glycobiology

    BioFiles Volume 5, Number 1 — Glycobiology Download Biofiles v5 n1 (4.4 Mb PDF) Table of Contents • Introduction • Sialic Acid Synthesis and Signaling • Mass Spectrometry of Glycans • Histological Detection of Pathogenic Fungi in Human Tissue • Select-HA™ • New Products for Glycobiology and Glycoche...

    Read the latest developments in CRISPR research

    read abstract Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting. Chen Fuqiang, Ding Xiao, Feng Yongmei, Seebeck Timothy, Jiang Yanfang, Davis GregoryD Nature Communications 2017-04-01 Bacterial CRISPR-Cas systems comprise diverse effector en...

    insulin-degrading enzyme
    Synonyms INSULYSIN
    Species Human (3416) , Species Mouse (15925) , Species Rat (25700) , Species Zebrafish (561390) , Species domestic cat (101093646) , Species cow (523752) , Species Horse (100071303) , Species dog (477768) , Species chicken (423814) , Species fruit fly (40248) , Species domestic guinea pig (100719651) , Species naked mole-rat (101706921) , Species sheep (101104194)
    Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

    Performance of DNAstable Plus® with plasmid DNA

    Scientific discoveries are at an all-time high resulting in an ever-increasing need to store and ship molecules, such as DNA, RNA and proteins. Most molecular laboratories are dependent on cold rooms and freezers for the storage of these basic molecules. Freezers and cold rooms use up valuable lab s...

    Polyethylene Glycol (PEG) Selection Guide

    Polyethylene glycol (PEG), also sometimes referred to as polyethylene oxide (PEO), is a condensation polymer of ethylene oxide and water that has several chemical properties that make it useful for biological, chemical and pharmaceutical applications. Polyethylene glycol can be easily synthesized by...

    N-Linked Glycans

    Glycobiology Analysis Manual Table of Contents N-Linked High Mannose Glycans N-Linked Complex Glycans N-Linked Fragments N-linked glycosylation, modification, and degradation are involved in a wide variety of processes in all organisms from archaea to eukaryotes. It is the most common covalent prote...

    Chitosan-based Biomaterials

    Chitin, a natural polysaccharide, is the second most abundant natural biopolymer in the world, after cellulose. It is the primary, high modulus fibrous component of the exoskeleton of arthropods including crab, shrimp and lobsters, as well as some fungi. Structurally, chitin is an insoluble, linear,...

    MystiCq® MicroRNA® Quantitation System

    Technology Overview Workflow Background Protocols miRNA isolation cDNA synthesis miRNA qPCR Advanced information Product selection guides Troubleshooting MicroRNAs are small (22-24 nucleotide) non-coding RNA molecules that are important regulators of gene expression in a variety of eukaryotic organi...

    Western Blotting Sample Preparation

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    CoMoCAT® MWNTs

    • Introduction • Properties of MWNTs • Challenges in Commercialization of MWNTs • Characterization of MWNTs and Quality Assurance Parameters • Applications of MWNTs • Conclusion Single-walled carbon nanotubes (SWNTs) and multi-walled carbon nanotubes (MWNTs) share some similarities, but also strikin...

    Supelco ASSET™EZ4 Dry Samplers for Isocyanates

    Related Products • ASSET Sampler • Analytical Standards Related Information • Sample Extraction Procedure for ASSET Video Introduction to ASSET (4min) Product flyer Two ASSET EZ4 Samplers Available Providing Ultimate Sensitivity for Vapor Phase and Particulate Isocyanates The ASSET EZ4 dry samplers ...

    Protein AQUA® – Protein Biomarker Quantitation

    Developed in collaboration with the Protein Quantitation Consortium, Sigma's AQUA Peptides enable accurate, efficient mass spectrometric quantitation of protein biomarkers. • Focus your analysis on significant protein biomarkers • Accurately quantitate low abundance proteins • Eliminate costly, time...

    Polyethylene Glycol Building Blocks for PEGylation

    Related Links • PEG Selection Guide • • Download PDF • Circulatory half-life is a key success factor for new drugs. In this respect, modification of potential candidates ranging from non-peptidic small molecules to peptides and proteins, antibody fragments, aptamers, and saccharides or oligonucleoti...

    Solid Phase Microextraction (SPME) Method for 4-methyl-1-cyclohexanemethanol (MCHM) and propylene glycol phenyl ether (PPH) in Water

    Background 4-Methyl cyclohexane methanol (MCHM) and propylene glycol phenyl ether (PPH) are chemicals used in the coal cleaning process. On January 9, 2014, there was an accidental release into the Elk River in West Virginia of an estimated 10,000 gallons of a mixture of these chemicals[1]. Accordin...

    Dendrons and Hyperbranched Polymers: Multifunctional Tools for Materials Chemistry

    Related Products • Dendron • Dendrimers • Surface Functionalized Nanoparticles • Biodegradable Polymers • Hydrophilic Polymers • Polyphosphoesters Related Articles • Dendritic Polyester Scaffolds for Drug Delivery Applications • Degradex® Microspheres and Nanoparticles for Drug Delivery Research and...

    Cell Death Detection ELISA PLUS Protocol

    Product No. CELLDETH-RO Use with non-proliferating cells Since the Cell Death Detection ELISAPLUS assay does not require prelabeling of cells, it can detect internucleosomal degradation of genomic DNA during apoptosis even in cells that do not proliferate in vitro (for example, freshly isolated tumo...

    Polymerase Chain Reaction - PCR Technologies Guide

    Related Links PCR Selection Guide Custom DNA and RNA Oligos OligoArchitect™ • Introduction and Historical Timelines • Polymerase Chain Reaction • Quantitative PCR • Digital PCR • Quantitative PCR and Digital PCR Detection Methods • PCR/qPCR/dPCR Assay Design • Sample Purification and Quality Assessm...

    MISSION® Pre-designed siRNA: A Higher Standard for siRNA Performance

    We've made ordering MISSION® siRNA for single gene targets easy through Sigma's state-of-the-art web interface. On this page: MISSION siRNA Benefits Validated Human siRNA siRNA pools Nano Scale siRNA References MISSION siRNA Libraries New Predesigned MISSION siRNAs are now available based on the lat...

    Glycoprotein Deglycosylation

    • • Download PDF • Aparagine-linked (N-linked) and serine/threonine-linked (O-linked) oligosaccharides are major structural components of many eukaryotic proteins. They perform critical biological functions in protein sorting, immune recognition, receptor binding, inflammation, pathogenicity, and ma...

    Carob (Ceratonia siliqua) | Plant Profile

    Synonyms / Common Names / Related Terms Alanine, algaroba, arobon, Caesalpinioideae (subfamily), carob bean gum, carob flour, carob gum, carobel, caruba, cellulose, ceratonia gum, Ceratonia siliqua, cheshire gum, China-Eisenwein, cinnamic acid, Fabaceae (family), flavonoids, free gallic acid, fructo...

    HPLC Troubleshooting Guide

    Although HPLC method development has been improved by advances in column technology and instrumentation, problems still arise. In this guide we offer you a systematic means of isolating, identifying, and correcting many typical problems. The important segments of an HPLC system are the same, whether...

    Organelle Isolation & Analysis Kits

    Enriching for organelles simplifies proteomic analysis and when partnered with protein pathway function allows key insight into development of healthy cell function as well as the disruption that leads to disease. The kits and reagents shown below enable researchers to enrich for functional mitochon...

    microRNA (miRNA) Stabilization in RNAstable™

    Introduction miRNAs play an important role in gene regulation. Genes encoding miRNAs are transcribed and then processed into mature single-stranded stem-loop structures that then bind to complementary mRNA transcripts to down-regulate gene expression. Dysregulation of miRNA expression and function h...

    RNAstable® with Microarray

    BioTechniques 47:667-670 (August 2009) doi 10.2144/000113209 RNA integrity is a critical factor in obtaining meaningful gene expression data. Current methodologies rely on maintaining samples in cold environments during collection, transport, processing, and storage procedures, which are also extrem...