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    Search term:"degradations"

    455 matches found for degradations

    Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions - Technical Article

    1,2Malar A. Azagarsamy, 1Navakanth R. Gandavarapu, 1,2Kristi S. Anseth* 1Department of Chemical and Biological Engineering and 2the Howard Hughes Medical Institute, University of Colorado at Boulder, Boulder, CO 80303 Email: Kristi.Anseth@colorado.edu 1,2Malar A. Azagarsamy, 1Navakanth R. Gandavarap...

    Photocatalysis

    The application of radical chemistry towards organic synthesis is well-developed and wide-reaching, though often hampered by a dependence on toxic radical initiators. These initiators are often used in sub- and even fully stoichiometric amounts and can require the use of short-wave light sources. Al...

    Imprint DNA Modification Kit Protocol

    • Product Description • Kit Components • Storage/Stability • Workflow • Product Profile • Procedure • Troubleshooting • Frequently Asked Questions • Materials • Materials Required Not Provided • References The Imprint DNA Modification Kit provides the reagents needed for bisulfite conversion and pos...

    LentiBrite™ Live Cell LC3 Autophagy [VIDEO]

    HT-1080 cells were plated in a chamber slide and transduced with LentiBrite™ GFP-LC3 lentiviral particles at an MOI of 20 for 24 hours. After media replacement and 48 hours further incubation, cells were incubated for 4 hours in EBSS containing a lysosome inhibitor, to induce autophagy and inhibit l...

    Acute and Chronic Inflammation: Microglia in Neuroprotection and Neurodegeneration

    The term neurodegeneration characterizes a chronic loss of neuronal structure and function leading to progressive mental impairments. The inci­dence of neurodegeneration generally increases with age. However, infectious agents may also induce neuronal death via apoptosis. Years of research have link...

    Reaching the “Peak” of Recovery: Improving Antibody Separations with the Inclusion of Organic Alcohols

    Related Articles • Reporter US Volume 34.4 • Robustness of the Discovery® HS F5 HPLC Column in the Study of Metabolomics • Rapid Determination of Protein Binding Affinity Using Solid Phase Microextraction • Analysis of Human Plasma Lipids Using sub-2 μm C18 UHPLC Column with MS Detection • Analysis ...

    TRC Library Citations

    Publish Sooner When You Partner with the MISSION® shRNA Team! The MISSION® TRC1.5 human and mouse shRNA libraries are the proven performers for small-scale to high-throughput RNAi screening. Below you will find a selection of papers where researchers have published in peer-reviewed journals using th...

    LentiBrite™ Live Cell p62 [VIDEO]

    Human mesenchymal stem cells (MSCs), were plated in a chamber slide and transduced with LentiBrite™ RFP-p62 lentiviral particles at an MOI of 40 for 24 hours. After media replacement and 24 hours further incubation, cells were incubated for 4 hours in EBSS containing a lysosome inhibitor, to induce ...

    Ultra-High Efficiency Perovskite-Perovskite Tandem Solar Cells

    Chemistry and Nanoscience Center, National Renewable Energy Laboratory, Golden, Colorado 80401, USA *Email: Kai.Zhu@nrel.gov Next generation solar cells have the potential to achieve conversion efficiencies beyond the Shockley-Queisser (S-Q) limit while also significantly lowering production costs. ...

    insulin-degrading enzyme
    Synonyms INSULYSIN
    Species Human (3416) , Species Mouse (15925) , Species Rat (25700) , Species Zebrafish (561390) , Species domestic cat (101093646) , Species cow (523752) , Species Horse (100071303) , Species dog (477768) , Species chicken (423814) , Species fruit fly (40248) , Species domestic guinea pig (100719651) , Species naked mole-rat (101706921) , Species sheep (101104194)
    Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

    microRNA (miRNA) Stabilization in RNAstable™

    Introduction miRNAs play an important role in gene regulation. Genes encoding miRNAs are transcribed and then processed into mature single-stranded stem-loop structures that then bind to complementary mRNA transcripts to down-regulate gene expression. Dysregulation of miRNA expression and function h...

    MystiCq® MicroRNA® Quantitation System

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    Frequently Asked Questions about Solvents in Hematology & Histology Research

    General Information Tax-Paid Ethanol Physical Properties Application Notes Returnable Containers General Information How do I get specific lot information or CofA for a solvent? A Certificate of Analysis is available by lot for each of our solvents and can be accessed through our Advanced Search Opt...

    Analytical Enzymes - Proteinase K

    E.C. 3.4.21.64 Synonym: Endoproteinase K On this page: • Products and Manufacturing Capabilities • Specificity • Physical Properties and Kinetics • Inhibitors • Applications • Solubility and Solution Stability This protein is available in the BioUltra Grade. Learn more here. Proteinase K exhibits br...

    Glycoprotein Deglycosylation

    • • Download PDF • Aparagine-linked (N-linked) and serine/threonine-linked (O-linked) oligosaccharides are major structural components of many eukaryotic proteins. They perform critical biological functions in protein sorting, immune recognition, receptor binding, inflammation, pathogenicity, and ma...

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    Polymerase Chain Reaction - PCR Technologies Guide

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    Astec Chiral Chromatography Bibliography - Recent Citations

    Copyright restrictions do not permit us to provide copies of the articles listed here. A direct HPLC method for the resolution and quantitation of the R-(-)- and S-(+)-enantiomers of vigabatrin (γ-vinyl-GABA) in pharmaceutical dosage forms using teicoplanin aglycone chiral stationary phase. Al-Majed...

    Chitosan: A Versatile Platform for Pharmaceutical Applications

    Raphael Riva and Christine Jerome* Center for Education and Research on Macromolecules University of Liege, Chemistry Department, Sart-Tilman, Building B6a, 4000 Liege, Belgium *Email: c.jerome@ulg.ac.be The development of new medical devices and pharmaceuticals plays an integral role in the medical...

    Blue-White Select™ Screening Reagent

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    Amplification of Damaged DNA with Restorase DNA Polymerase (R1028)

    • Background • Reagents • Preparation Instructions • Storage and Stability • Procedure • Primer Hot Start • Materials • Troubleshooting Guide • References Restorase® DNA Polymerase with 10x Reaction Buffer combines Sigma's Long and Accurate enzyme technology with a DNA repair enzyme resulting in a b...

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    Product No. 03708152001 Biotinylated protein appears in flow-through Column overloaded Reduce sample load. Binding conditions were not optimal In some cases, monobiotinylated proteins may require a higher salt concentration to bind to the mutant streptavidin. Increase ammonium sulfate concentration ...

    Reference Standards for Analyzing Polyphenol Catechins

    • • Download PDF • techservice@sial.com Catechins have become a hot topic in today’s health conscious world. Current research suggests that catechins aid health by: • Reducing formation of athersclerotic plaques • Suppressing the growth of tumors by inhibiting enzymes involved in the spread of cance...

    Handling and Storage of Custom Peptides

    1. The product vial should be tightly capped at all times when not in use. 2. While some peptides and proteins are stabile at 4 °C, we recommend –20 °C for short-term storage (1–2 weeks) and –80 °C for longer storage. It is always advisable to store away from bright light. 3. Exposure to moisture wi...

    Enzyme Explorer Key Resource: Protease Inhibitors

    Overview of Proteolytic Activities and Inhibition Strategies Broad-Spectrum Inhibitors of Proteolytic Enzyme Classes Broad-Spectrum Protease Inhibitor Cocktails Protease Inhibitor Cocktail Products Protease Inhibitor Products Protease Inhibitor Panel (INHIB-1) (PDF 88 kb) Recombinant Protein Express...