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488 matches found for degradations

RNA Extraction and Purification

Related Links • Genomics Express eNewsletter • RNA Stabilization and Protein Stabilization in Tissue Extracts with Stabilyser™ Reagent • DNA & RNA Purification • Molecular Biology Workflow Need to isolate nucleic acids and protein from a limited amount of tissue sample, but are concerned about degra...

Effect of Enzyme Titer and pH on Hydrolysis Efficiency Using Recombinant Limpet β-Glucuronidase Enzyme

Jim Blasberg1, Danny Taglicht2, Ena Orzech2, Jeff Turner1, Ben Cutak1, and Kevin Ray1 1 – MilliporeSigma, St. Louis, MO 2 – MilliporeSigma, Jerusalem, Israel Urine drug testing has become an important tool to monitor compliance and detect the presence of illicit drugs. The primary metabolites of man...

Imprint® DNA Modification Kit Protocol

• Product Description • Kit Components • Storage/Stability • Workflow • Product Profile • Procedure • Troubleshooting • Frequently Asked Questions • Materials • Materials Required Not Provided • References The Imprint® DNA Modification Kit provides the reagents needed for bisulfite conversion and po...

Partial PROTACs for Targeted Protein Degradation

Targeted protein degradation (TPD) is an emerging drug discovery strategy that allows access to difficult-to-treat diseases. While traditional small-molecule therapeutics may only allow access to ~20% of the proteome, degradation techniques may open the door to the other 80%. Learn about our Partial...

Surface-enhanced Solar Energy Conversion Systems Using Gold and Silver Nanoparticles

Related Articles • Electrode Materials for Lithium Ion Batteries • Materials for Clean H2 Production from Bioethanol Reforming • Changing the Landscape of Environmental and Energy Research Through Novel Nanoscale Materials • Precise Nanoparticles for Optoelectronics Applications • Electronics and Se...

S-Gal Frequently Asked Questions

S-Gal™/LB Agar Blend — Frequently Asked Questions What purpose does the ferric ammonium citrate component serve in the S-Gal/LB Agar blend? Ferric ions provided by the ferric ammonium citrate are chelated by the by-product of S-Gal, created when it is cleaved by b-galactosidase, to form the black pr...

Vitamin B6, Pyridoxal and Pyridoxine, in Cell Culture

Importance and uses of the B6 vitamins, pyridoxal and pyridoxine, in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures Vitamin B6, in its various forms, is an essential additive to cell culture. It is a component of the basal medium formulation. Vitamin B6 has...

Reproducibility with Biological Buffers

What are biological buffers? Biological buffers are organic substances that maintain a constant pH over a given range by neutralizing the effects of hydrogen ions. Buffers are commonly used in biochemical, biological and environmental studies to maintain or control the acidity of a solution within a...

GenElute Bacterial Genomic DNA Kit Protocol

Our GenElute™ Bacterial Genomic DNA Kit provides a simple and convenient way to isolate pure DNA from a variety of cultured bacteria. The kit contains all of the reagents needed to isolate and purify genomic DNA from gram-negative bacteria. For most gram-positive bacteria, the kit must be used in co...

insulin-degrading enzyme
Synonyms INSULYSIN
Species Human (3416) , Species Mouse (15925) , Species Rat (25700) , Species Zebrafish (561390) , Species domestic cat (101093646) , Species cow (523752) , Species Horse (100071303) , Species dog (477768) , Species chicken (423814) , Species fruit fly (40248) , Species domestic guinea pig (100719651) , Species naked mole-rat (101706921) , Species sheep (101104194)
Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

The MISSION® Target ID Library for Human miRNA Target Identification and Discovery

Carol A. Kreader and Kevin P. Forbes One of the main problems miRNA researchers face today is global identification of gene targets that are functionally regulated by their miRNA of interest. Unfortunately, bioinformatic predictions are unreliable and there is little agreement between different algo...

What is Hyaluronan?

Related Links • 3D cell culture • 3D hydrogels • HyStem® hydrogels Related Products • Cell culture • 3D cell culture • Brief Summary • Nomenclature • Chemistry and Physical Properties • Biological Roles • Degradation of Hyaluronan • Hyaluronan Synthesis • Glycosil vs. Unmodified HA • History of Hyal...

Antibodies in Practice: General Information

Selection and Use Antibody Titer and Concentration Storage and Handling of Antibodies Considerations when selecting an antibody for use in an experiment Once you have identified your target antigen and have chosen your detection method, you must then choose one or more primary antibodies to detect y...

Circular DNA Amplification using TempliPhi™

illustra™ TempliPhi™ DNA Amplification Kits from GE Healthcare are novel products developed to exponentially amplify single- or double-stranded circular DNA templates by RCA, shown schematically in Figure 7.3 (8, 9). Amplified products can be used in downstream applications such as sequencing and mo...

STRboost™ Protocol for enhanced PCR with difficult samples

STRboost is a novel reagent that substantially enhances multiplex PCR amplification reactions used for human identification applications, resulting in improved accuracy, sensitivity and precision. Including STRboost in amplification reactions helps resolve stochastic effects typically associated wit...

The Impact of Water on a Calcium Assay

This paper discusses the impact of water on the Arsenazo calcium assay and the fact that water purity may influence the accuracy of assay results. Bacteria appear as the most common source of problems for the calcium assay, due to the release of proteins and small organic acids that can bind to calc...

Custom DNA Oligos Modifications

Related Links • Custom DNA and RNA Oligos • Custom qPCR Probes • Custom and Predesigned siRNA • Custom DNA and RNA Oligos & qPCR Probes portfolio: Discover More We offer over 200 modifications for both DNA and RNA oligonucleotides and probes. We can attach fluorescent dyes to oligos at the 5'-end, 3...

Universal Protease Activity Assay: Casein as a Substrate [VIDEO]

A. Abstract Proteases break peptide bonds. It is often necessary to measure and/or compare the activity of proteases. Our non-specific protease activity assay may be used as a standardized procedure to determine the activity of proteases, which is what we do during our quality control procedures. In...

En Route to Carbon Nanotube Electronics

Professor Moonsub Shim Department of Materials Science and Engineering and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign Ballistic electron transport, current carrying capacities on the order of 109 A/cm2, and one of the largest known specific stiffness ar...

Ultra-High Efficiency Perovskite-Perovskite Tandem Solar Cells

Chemistry and Nanoscience Center, National Renewable Energy Laboratory, Golden, Colorado 80401, USA *Email: Kai.Zhu@nrel.gov Next generation solar cells have the potential to achieve conversion efficiencies beyond the Shockley-Queisser (S-Q) limit while also significantly lowering production costs. ...

Improve the Efficiency of Your Impurity Testing: Impurity Solution Mixtures for use in Pharmaceutical Analysis

To ensure the safety of pharmaceutical products, active pharmaceutical ingredients (APIs) need to be tested thoroughly. The accurate detection and control of impurities in drug substances and products is an essential element of ICH and GMP requirements. Reference Materials for these impurities are o...

KAPA PROBE FAST qPCR Kits FAQs

What are the recommended applications for KAPA PROBE FAST qPCR Master Mix (2X) Kits? • Gene expression analysis • SNP genotyping/allelic discrimination • Microarray validation • NGS validation What is the enzyme in KAPA PROBE FAST qPCR Master Mix (2X) Kits? This product contains KAPA Taq HotStart DN...

Micro and Nanometer Scale Photopatterning of Self-Assembled Monolayers

Graham J. Leggett* Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, United Kingdom *Email: Graham.Leggett@shef.ac.uk Self-assembled monolayers (SAMs) have attracted enormous interest for a wide variety of applications in micro- and nano-technology. In this article, we ...

Water for Next-Generation Sequencing

Water is used throughout the next-generation sequencing (NGS) workflow, from DNA fragmentation to sequencing runs and instrument cleaning. Using the appropriate water quality for each step will not only eliminate the risk of water contaminants interfering with nucleic acids and the many enzymatic re...

Cell Migration & Invasion Assays

The Boyden Chamber Assay Cell Migration Assays Cell Invasion Assays Microfluidic Migration Device In Vitro Scratch Assay ECM Proteins References Metastasis is the cumulative result of multiple changes in tumor cells and their microenvironment that enables cellular migration and invasion into healthy...

Organelle Isolation & Analysis Kits

Enriching for organelles simplifies proteomic analysis and when partnered with protein pathway function allows key insight into development of healthy cell function as well as the disruption that leads to disease. The kits and reagents shown below enable researchers to enrich for functional mitochon...

Product Highlights for Organic and Inorganic Synthesis

NEW! Fluoroalkylation: Expansion of Togni Reagents NEW! Fragment-Based DNA-Encoded Library for Drug Discovery NEW! Pym-DATB: Highly Efficient Amidation Catalyst NEW! Ketosulfoxonium Ylides: Safe, Versatile Carbene Equivalents NEW! MCAT- 53™ Catalyst for Ruthenium Formation NEW! Photocatalysis NEW! P...

Flexible Organic Transistors for Biomedical Applications

Tsuyoshi Sekitani,* Kazunori Kuribara, Tomoyuki Yokota, Takao Someya Department of Electric and Electronic Engineering, Department of Applied Physics, School of Engineering University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan Exploratory Research for Advanced Technology (ERATO) Japan S...

MISSION™ shRNA Library: Next Generation RNAi

By Stephanie Uder, Henry George, and Betsy Boedeker Sigma-Aldrich Corporation, St. Louis, MO, USA Introduction The technology of RNA interference emerged in its earliest form following a 1998 study in Caenorhabditis elegans1and has since rapidly evolved to its current form as a revolutionary tool fo...

Unnatural Amino Acids - ChemFiles 2008, 8.7, 3.

• • Download PDF • Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research. Due to their unlimited structural diversity and functional versatility, they are wi...

Efficient dye-sensitized solar cells for direct conversion of sunlight to electricity

Kuppuswamy Kalyanasundaram* and Michael Grätzel Laboratory for Photonics and Interfaces (LPI), Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland *Email: k.kalyanasundaram@epfl.ch Researchers have explored many processes where solar irradiation can be used to create an ec...