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483 matches found for degradations

Hydrogel IPN Kits

Sigma-Aldrich® Materials Science offers two new ready-to-use hydrogel kits for the encapsulation and delivery of drugs, biomolecules, and cells. The hydrogels fuse the durability of synthetic polymers and the biorecognition of a natural protein to create a biocompatible delivery platform. The biodeg...

Ginseng (Panax ginseng) | Plant Profiler

Synonyms / Common Names / Related Terms Ginseng (American ginseng, Asian ginseng, Chinese ginseng, Korean red ginseng, Panax ginseng:Panaxspp., includingP. ginsengC.C. Meyer andP. quinquefoliusL., excludingEleutherococcus senticosus), Acetylenic alcohol, acidic polysaccharides, acupuncture-moxibusti...

Mesoporous Titanium Dioxide Thin Films

Related Articles • Synthesis of Melting Gels using Mono-Substituted and Di-Substituted Alkoxysiloxanes • Nanostructured Materials through Ultrasonic Spray Pyrolysis • Advanced Inorganic Materials for Solid State Lighting • Materials for Energy Efficiency (4.18 Mb PDF) • Nanoscale Surface Modificatio...

Claycomb Medium w/o L-Glutamine Product Information Sheet

Claycomb Medium, named after Dr. William Claycomb who established the HL-1 cell line, is specifically designed for the growth of murine cardiomyocytes. HL-1 cells are the first cell line established that can maintain the differentiated cardiomyocyte­phenotype and contractile activity in vitro. The H...

shRNA Frequently Asked Questions for General shRNA Use

What is shRNA? Do you guarantee knockdown using your clones? What gene family sets are available? Why is there always a clone for the 3' UTR region? Can I search and design my own shRNAs on the TRC "Search for shRNA hairpin sequences page?" Your MISSION TRC shRNA clones are sequenced after cloning, ...

Media Formulation Products

Carrier and Transport Proteins Hormones Hydrolysates Lipids and Lipid Carriers Other Supplements Carrier and Transport Proteins Cell culture is essential to biotechnology. Historically, cells have been cultured in serum containing media. Serum is a source of many nutrients required by cells to proli...

Injectable Hydrogels for Cell Delivery and Tissue Regeneration

Prathamesh M. Kharkar,1 April M. Kloxin1,2* 1Materials Science and Engineering and 2Chemical and Biomolecular Engineering University of Delaware, Newark, DE 19716 USA *Email: akloxin@udel.edu The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regenerat...

Metal Hydrides for NiMH Battery Applications

• • Download PDF • University of Nevada, Reno, College of Engineering Reno, NV 89557 *Email: dchandra@unr.edu Rechargeable solid-state batteries are becoming increasingly important due to wide-spread use in computers, portable electronics, and vehicular applications. The Partnership for a New Genera...

Perfluorosulfonic Acid Membranes for Fuel Cell and Electrolyser Applications

Deborah Jones Institut Charles Gerhardt CNRS–University of Montpellier, 34090 Montpellier, France Email: Deborah.Jones@univ-montp2.fr Introduction PFSA Polymer Types Composition, Structure, and Synthesis Routes PFSA Ionomer Dispersions Conductivity and Water Uptake Membrane Durability Better Membran...

insulin-degrading enzyme
Synonyms INSULYSIN
Species Human (3416) , Species Mouse (15925) , Species Rat (25700) , Species Zebrafish (561390) , Species domestic cat (101093646) , Species cow (523752) , Species Horse (100071303) , Species dog (477768) , Species chicken (423814) , Species fruit fly (40248) , Species domestic guinea pig (100719651) , Species naked mole-rat (101706921) , Species sheep (101104194)
Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

SigmaFAST™ Protease Inhibitor Cocktail Tablet, EDTA-Free

SigmaFAST™ Protease Inhibitor Cocktail Tablet, EDTA-Free (Cat. No. S8830) is our water-soluble, convenient protease inhibitor cocktail tablet that protects against: • Serine Protease • Cysteine Proteases • Aspartic Proteases • Metalloproteases Because S8830 is EDTA-free, it does not interfere with d...

Protocols for Membrane Scaffold Proteins and Nanodisc Formation

The following material related to Nanodisc Technology is adapted from on-line content of the research group of Professor Stephen Sligar of the University of Illinois at Urbana-Champaign, with the kind permission of Professor Sligar. The concept of membrane scaffold proteins was originally derived fr...

Chiral Chromatography FAQ

Chirality & Chiral Chromatography Chiral HPLC Column Selection & Screening Astec CHIROBIOTIC Chiral HPLC Astec CYCLOBOND Chiral HPLC Preparative Chiral HPLC Tips and Tricks for Chiral HPLC Chiral GC What is chirality? Chirality belongs to the discipline of stereochemistry, which is the study of the ...

Simplicon RNA Troubleshooting Tips

No or Low RNA yield 1. Check DNA template: Check the amount, quality and size of the linearized DNA (single digestion). Contamination of phenol & chloroform will reduce the activity of the T7 RNA polymerase. Wash DNA pellet with 70% ethanol to remove salts and impurities. 2. Check transcription reac...

Mitochondrial Dysfunction and Metabolic Defects

• • Download PDF • BioFiles 2011, 6.4, 14. Defects in mitochondrial function are associated with insulin resistance in both human and animal studies. Insulin resistance is associated with a decrease in the number, oxidative capacity, size, and density of mitochondria. Understanding the mechanisms th...

Avocado (Persea americana) | Plant Profiler

Synonyms / Common Names / Related Terms Abokado, aguacate, ahuacate, ahuacatl, alligator pear, avocado pear, Avocato, Persea americana, Persea americana var. drymifolia Blake, Persea gratissima, Persea leiogyna, Persea nubigena var. guatamalensis L., Persea persea, Laurus persea. Mechanism of Action...

Beta Amino Acids

Although they are less abundant than their α-analogues, β-amino acids occur in nature both in free form and bound to peptides. Oligomers composed exclusively of β-amino acids (so-called β-peptides) might be the most thoroughly investigated peptidomimetics. Besides being remarkably stable to metaboli...

Inorganic Interface Layer Inks for Organic Electronic Applications

The commercialisation of organic electronic devices such as organic photovoltaic cells (OPV) and organic light-emitting diode (OLED) lighting continues to accelerate. To make these large-area, high volume applications fully accepted by the mass market, production costs need to be significantly lower...

Handling and Storage of Custom Peptides

1. The product vial should be tightly capped at all times when not in use. 2. While some peptides and proteins are stabile at 4 °C, we recommend –20 °C for short-term storage (1–2 weeks) and –80 °C for longer storage. It is always advisable to store away from bright light. 3. Exposure to moisture wi...

Flow Cytometry Protocol

By focusing on analysis techniques and protocols specific for Cancer Research, we are putting your research needs first. We will be featuring different cancer research tools throughout the year, providing you with the latest techniques and products. Flow Cytometry in Cancer Research Flow cytometry a...

EX-CELL® Advanced™ CHO Fed-batch Media and Feed Platform: PIS

Two studies were executed to evaluate EX-CELL Advanced CHO Fed-batch Platform in which the first study assessed indicative performance measures (viable cell density and titer) and the second study for resulting protein quality as demonstrated by relative glycan distribution (%). Study 1 Design Three...

Yeast Cell Lysis

• CelLytic™ Y • CelLytic Y Plus Kit CelLytic™ Y CelLytic Y Cell Lysis Reagent is versatile, phosphate-free, and non-denaturing. It provides an effective method for cell lysis and protein solubilization (Figure 1). Target proteins maintain immunoreactivity or biological function. The protocol is brie...

Quantum Dots

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Organic Pollutant Standards

An extensive and broad selection of organic chemicals that are potentially harmful for people and for the environment are available as analytical standards and CRMs including PAHs, PCBs, phenols, air pollutants, explosives, chemical warfare degradation products, plasticizers, disinfectant by-product...

Deoxyribonuclease I

Catalog Number: D7291 Storage Temperature –20 °C CAS RN: 9003-98-9 EC 3.1.21.1 Synonym: DNase I Product Description Precautions and Disclaimer Storage/Stability Procedure Product Profile Materials References Deoxyribonuclease I is isolated from bovine pancreas and is processed to reduce RNase activi...

Reliable extraction of DNA from Whatman™ FTA™ cards

This study examined the yield and quality of DNA from samples applied to Whatman FTA cards, using five common methods of DNA extraction. The data demonstrate that all five methods yield purified DNA of sufficient quantity and quality for both quantitative PCR and short tandem repeat analyses. In add...

MAPKKKs

Mitogen-activated protein kinase (MAPK) signaling pathways mediate cellular responses to many stimuli including growth factors, hormones, cytokines and environmental stresses. MAPK pathways can be divided into those that predominantly respond to mitogens and those that predominantly respond to stres...

Stabilization of poly(A) mRNA transcripts in RNAstable®

Introduction RNAstable is a novel stabilization product developed to protect RNA samples from degradation at room temperature. The technology is based on nature’s principles of anhydrobiosis (meaning “life without water”), a biological mechanism used by some multicellular organisms that ensures thei...

cOmplete™ His-Tag Purification Resin Protocol & Troubleshooting

Product No. COHISR-RO FPLC Purification Under Native Conditions Using the ÄKTAexplorer 100 System A detailed procedure for automated Fast Protein Liquid Chromatography (FPLC) using the ÄKTAexplorer 100 System is available in the Instructions for Use of cOmplete His-Tag Purification Column (067815350...

Western Blotting Sample Preparation

Chapter 2, Extracted from Western Blotting Principles and Methods, GE Healthcare Life Science, 2011 Symbols This symbol indicates general advice on how to improve procedures or recommends measures to take in specific situations ** indicates a third party trademark The importance of good sample prepa...

Enantiomeric Purities of Pharmaceuticals Using Carbohydrate-based Isothiocyanates

In the first two papers of this series (Analytix Nr. 1/2010 and 2/2010), the efficient enantiomeric analysis of (a) alkyl oxiranes, and (b) amino acids was described using inexpensive reversed phase columns (as an alternative to high cost so-called “chiral columns”) in combination with monosaccharid...