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45 matches found for fluorinations

1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine (TFEDMA)

Aldrich ChemFiles 2008, 8.3, 4. 1,1,2,2-Tetrafluoroethyl-N,N-dimethylamine (TFEDMA) is a new, mild, and selective nucleophilic fluorination reagent for fluorination of alcohols and activated carbonyl compounds.1 In contrast to the similar Yarovenko–Raksha reagent (2-chloro-1,1,2-trifluoroethyl- N,N-...

Bo Xu Group

Professor Product Portal Index Professor Bo Xu The research of the Hammond-Xu Group is focused on the understanding of novel interactions between organic and organometallic compounds from the perspective of physical organic chemistry. The ultimate goal of enabling user-friendly synthesis of organic ...

Perfluorosulfonic Acid Membranes for Fuel Cell and Electrolyser Applications

Deborah Jones Institut Charles Gerhardt CNRS–University of Montpellier, 34090 Montpellier, France Email: Deborah.Jones@univ-montp2.fr Introduction PFSA Polymer Types Composition, Structure, and Synthesis Routes PFSA Ionomer Dispersions Conductivity and Water Uptake Membrane Durability Better Membran...

Selectfluor™

Selectfluor™ (1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate), or F-TEDA) is a user-friendly, mild, air- and moisture-stable, non-volatile reagent for electrophilic fluorination. Selectfluor™ is capable of introducing fluorine into organic substrates in one step, with...

Macmillan Imidazolidinone Organocatalysts in Chemical Sythesis

Metal-free Asymmetric Catalysis Developed by Professor David MacMillan at Caltech, imidazolidinone-based OrganoCatalysts™ are designed to serve as general catalysts for a variety of asymmetric transformations. The first highly enantioselective organocatalytic Diels-Alder reaction using (5S)-2,2,3-tr...

Baran Reagents FAQs

• • Download PDF • Baran Group – Professor Product Page Professor Product Portal Index What do the Baran reagents do? Allow the placement of alkyl groups onto molecules in drug discovery by replacing a C-H bond with the corresponding C-C bond (trifluoromethyl, difluoromethyl, isopropyl, etc.). Alter...

Colby Group - Professor Product Portal

Professor Product Portal Index Professor David Colby Prof. David Colby's laboratory is developing synthetic methods to enable the efficient modification of complex molecules, such as natural products, as well as the production of fluorinated compounds. They have focused on understanding how to cleav...

J. Hu Group – Professor Product Portal

Related Links • VIEW PRODUCT LIST • Professor Product Portal • Catalysis and Inorganic Chemistry • Organic Synthetic Chemistry Professor Product Portal Index Professor Jinbo Hu The major research interests of Prof. Jinbo Hu's lab include the development of new fluorination reagents and reactions, es...

Ishikawa’s Reagent

Ishikawa’s reagent (N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine) has also demonstrated utility in fluorination. In a recent example, Ishikawa’s reagent has been used in a clean and reproducible fluorination protocol on an intermediate in the total synthesis of 26-fluoroepothilone B(Scheme 14)1 Sch...

MacMillan Imidazolidinone OrganoCatalysts™ | Aldrich ChemFiles 2007, 7.9, 8.

Aldrich ChemFiles 2007, 7.9, 8. Developed by Professor David MacMillan at Caltech, imidazolidinone based OrganoCatalysts™ are designed to serve as general catalysts for a myriad of asymmetric transformations. The first highly enantioselective organocatalytic Diels–Alder reaction using a chiral Organ...

Hartwig Group – Professor Product Portal

Related Links • VIEW PRODUCT LIST • Professor Product Portal • Catalysis and Inorganic Chemistry • Organic Synthetic Chemistry Professor Product Portal Index Professor John Hartwig Professor Hartwig's research focuses on the discovery and understanding of new reactions catalyzed by transition metal ...

Jimmie Weaver Group - Professor Product Portal

Professor Product Portal Index Professor Jimmie Weaver Organofluorine chemistry is an essential part of drug discovery programs as well as agrochemical programs and even plays a major role in materials chemistry. Despite the undeniable importance of fluorinated organic molecules, our ability to synt...

AlPhos and [(AlPhosPd)2•COD] for Pd-Catalyzed Fluorination

Fluorine containing aromatics (ArF) are desirable compounds with applications in medicinal chemistry and the agricultural industry. While Pd-catalyzed cross coupling has enabled the mild and general synthesis of aryl–C, –N, and –O bonds, the development of an analogous aryl–F bond forming process ha...

Fluorinating Reagents

• • Download PDF • The importance of selectively fluorinating compounds in medicinal chemistry, biology, and organic synthesis is well appreciated and provides a major impetus to the discovery of new and mild fluorinating agents that can operate safely and efficiently. Elemental fluorine and many el...

MacMillan Imidazolidinone OrganoCatalysts™

Product Highlights • Superior enantiocontrol in numerous transformations • High activities at low catalyst loadings • Extraordinary functional group tolerance • Asymmetric α-fluorination employed in natural product synthesis MacMillan and co-workers have created chiral imidazolidinone organo-catalys...

Iodotoluene difluoride

The importance of selectively fluorinating compounds in medicinal chemistry, biology, and organic synthesis is well appreciated and provides a major impetus to the discovery of new fluorinating agents that can operate according to an efficient, safe, and mild criteria. Elemental fluorine, and many e...

DMPU-HF: Novel Nucleophilic Fluorinating Reagent

An HF-based nucleophilic fluorination reagent is ideal for cost and atom economy. The most commonly used HF-based reagents are HF-organic base complexes like Olah’s reagent (pyridine-HF) and triethylamine-HF. However, these organic bases reduce the acidity of the system and may interfere with metal ...

Acid Halogenation Reagents

Aldrich ChemFiles 2007, 7.2, 3. The generation of an acid chloride is an obvious way to activate the carboxy group for amide bond formation. However, practical application of acid chlorides in peptide synthesis is restricted, because they are prone to side reactions and racemization. In spite of thi...

Lead Development for Early Drug Discovery

Lead development requires identification of a lead small molecule with potential to be made into a clinical candidate. Once identified, the chemical structure of the lead compound is taken for chemical modifications to improve potency, selectivity or pharmacokinetic (PK) parameters. Improving the hi...

Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)

The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules. Deoxyfluorination of alcohols is a well-precedented technique for synthesizing aliphatic fluorides. Diethylaminosulfur trifluoride (DAST) has emerged as the most popul...

XtalFluor-E® and XtalFluor-M®: Convenient, Crystalline Deoxofluorination Reagents

• • Download PDF • Figure 1. Structures of the new deoxofluorination reagents, XtalFluor-E (719439) and XtalFluor-M (719447). The introduction of fluorine into the framework of an organic molecule is an important synthetic transformation. Historically, though, this transformation has been fraught wi...

Stephen Buchwald Group – Professor Product Portal

Professor Product Portal Index Professor Stephen Buchwald The Buchwald group has developed a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The ligands are electr...

Iodotoluene Difluoride in Chemical Synthesis

A New, Mild Oxidation and Fluorination Reagent The importance of selectively fluorinating compounds in medicinal chemistry, biology, and organic synthesis is well appreciated and provides a major impetus to the discovery of new fluorinating agents that can operate according to an efficient, safe, an...

Chemfiles Volume 6 Article | MacMillan Imidazolidinone OrganoCatalysts™

Developed by Professor David MacMillan at Caltech, imidazolidinonebased organocatalysts are designed to serve as general catalysts for a myriad of asymmetric transformations. The first highly enantioselective organocatalytic Diels–Alder reaction using a chiral organocatalyst (569763) was reported in...

Drying Agents - AL-143

AL-143 Mineral Adsorbents, Filter Agents and Drying Agents Home / Molecular Sieves / Activated Alumina / Activated Carbon / Diatomaceous Earth Ascarite II® Adsorbents / Montmorillonites and other Mineral Adsorbents / Drying Agents Toxicity and Handling / References VII. DRYING AGENTS Many products s...

TADDOL

• • Download PDF • The chiral auxiliaries TADDOLs (α,α,α,α-tetraaryl-1,3-dioxolane-4,5- dimethanols) developed by Seebach's group have found numerous applications in asymmetric synthesis ranging from utilization as stoichiometric chiral reagents or in Lewis acid mediated reactions, to roles in catal...

Professor Product Portal - Baran Group

Professor Product Portal Index Professor Phil S. Baran Congratulations to Dr. Baran for being named a 2013 MacArthur Fellow. Learn more The Baran Group works with Sigma-Aldrich in providing a portfolio of zinc-based reagents promoting difluoromethylation, trifluoromethylation, trifluoroethylation an...

Abigail Doyle Group – Professor Product Portal

Professor Product Portal Index Professor Abigail Doyle Research in the Doyle group focuses on two areas: nucleophilic fluorination and nickel catalysis. The Doyle group has developed several reagents that advance these research areas. In fluorination, 2-pyridinesulfonyl fluoride (PyFluor) can be use...

Continuous Flow Synthesis in Microstructured Reactors — A New Way of Thinking Chemical Synthesis

• • Download PDF • Organic chemists usually spend a substantial amount of time on the development of synthetic routes to new materials. The best pathways need to be chosen and reaction conditions must be optimized. Once a product is successful and demand for larger quantities is growing, the whole s...

ChemFiles

ChemFiles is a FREE quarterly newsletter written by our experts from Product Management and R&D, highlighting our latest innovative products from: Building Blocks, Synthetic Reagents, Asymmetric Synthesis, Catalysis and Inorganic Reagents, Organometallic Reagents, Chemical Biology, Specialty Synthes...