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59 matches found for functional_genomics

Functional Genomics Screening

As a leader in Functional Genomics screening, we are proud to offer extensive options in both arrayed and pooled screening libraries. Whether you are reducing gene expression utilizing shRNA or completely knocking out gene expression with CRISPR, we have the right library for your needs. /catalog/se...

Read the latest developments in CRISPR research

read abstract Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes Adriana CarolinaGonzalez1MichaelaSchweizer2SebastianJagdmann1ChristianBernreuther3ThomasReinheckel4PaulSaftig1MarkusDamme15 23-01-2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late...

Genome Editing Plants Webinar

The CRISPR/Cas genome editing system has revolutionized almost every aspect of the life science industry. This exciting method is rapidly advancing fundamental plant research, and plant biotechnology. In this webinar, we introduce strategies for gene editing in plants with our portfolio of CRISPR/Ca...

Reagents for Functional Genomics Screening

We provide the full spectrum of products needed to perform your screen. From cell lines to oligos, and everywhere in between, we have you covered. Search the product list below. Product No. Description D6171 Dulbecco’s Modified Eagle’s Medium - high glucose D8537 Dulbecco’s Phosphate Buffered Saline...

Western Blot Resources

Protect Your Proteins Eliminate vulnerabilities in your western workflow Western blotting, also known as immunoblotting, is a well established and widely used technique for the detection and analysis of proteins. This detection method is based on building an antibody/protein complex via specific bin...

CRISPR Webinars [VIDEOS]

CRISPR Webinars • Primary T-Cell Editing using Nickase RNPs • New CRISPR Strategies in Visualization and Chromatin Accessibility • Cas9 GFP, Proxy CRISPR. CRISPR Chrom • SygRNA® Synthetic CRISPR • Cas9 Proteins • SAM CRISPR Activator Libraries • Sanger Whole-Genome Arrayed CRISPR Screening Library •...

The mirPremier™ microRNA Isolation Kit for purification of miRNA from diverse biological sources.

mirPremier™ microRNA Isolation Kit More rapid, more pure, less hazard, less hands on. The mirPremier microRNA Isolation Kit complements the already robust MISSION® RNAi product portfolio which includes a broad choice of MISSION siRNA and shRNA products and services such as libraries, mRNA detection ...

Sigma Life Science Online Product Catalog

Biochemicals & Reagents • Amino Acids • Antibodies • Antibiotics • Biological Buffers • Carbohydrates • Detergents • Enzymes, Inhibitors, and Substrates • Life Science Labware • Lipids • Peptides • Proteins & Derivatives • Stable Isotopes • Additional Biochemicals & Reagents Techniques & Application...

Product Directory Home

Analytical / Chromatography • Analytical Standards • Applications • Derivatization Reagents • Gas Chromatography • HPLC • LPLC/TLC/Paper Chromatography • Microbiology • Resins & Media • Sample Prep/Purification • Solid Phase Microextraction • Syringes • Titration • Vials • More.. Materials Science •...

Epigenetics: DNA Methylation, Chromatin Modification

Epigenetics describes changes that are stable, but potentially reversible alterations in gene expression, that occur without permanent changes in DNA sequence and can still be passed on from generation to generation. Epigenetically controlled genes are activated or repressed without any change in DN...

Target Identification & Validation for Early Drug Discovery

Early stages of drug discovery start with initial steps of target identification and moves to the later stages of lead optimization. Multiple sources including academic research, clinical works and commercial sector help in the identification of a suitable disease target. The chosen target is then u...

Cracking the Cancer Code

Biowire Spring 2011 — Cell Lines — Models of Disease Subscribe to Biowire and eBiowire Download Biowire Spring 2011 (7.0 Mb PDF) Biowire Spring 2011 Home Few words can be as terrifying. And that apprehension, once confined to conversations in the clinic, has gone on to pervade our collective health ...

Functional Genomics Resource Center

Search below for a wide variety of helpful links to answer any questions you may have about our Genome Engineering products. From protocols and FAQs to webinars and vector maps, find everything you need from your trusted partner in Functional Genomics reagents. MISSION™ CRISPR • CRISPR/Cas9 Basics &...

Modified Cells for Enhanced R&D

Biowire Spring 2011 — Cell Lines — Models of Disease The use of human cell lines in research has been fundamental to our understanding of human biology, drug discovery, and the manufacture of vaccines. However, our ability to manipulate the genome of these cells to create better models of disease or...

Integration of Sigma® TransPlex® WTA and the Complete WTA2 Kits with the Affymetrix Microarray Workflow

Amplification products generated by the TransPlex® WTA and Complete WTA2 kits are suitable for microarray target for expression analyses, and can be incorporated into existing Affymetrix workflows through a procedure known as Pico Profiling1,2. Pico Profiling is comprised of a modified Affymetrix Ge...

MISSION™ shRNA Library: Next Generation RNAi

By Stephanie Uder, Henry George, and Betsy Boedeker Sigma-Aldrich Corporation, St. Louis, MO, USA Introduction The technology of RNA interference emerged in its earliest form following a 1998 study in Caenorhabditis elegans1and has since rapidly evolved to its current form as a revolutionary tool fo...

Protein Quantitation: Bradford Reagents and Bicinchoninic Acid Assay

Protein quantitation may be accomplished through a number of methods, the most reliable of which include the BCA (bicinchoninic acid) assay and the Bradford assay. Alternative protein quantitation methods include the Lowry assay for protein quantitation and derivitization of N-terminal amines. In ad...

CompoZr® Targeted Integration Kits site integration and expression

Now Available! Targeted Integration into the Rat Genome at the Rosa26 Locus CompoZr Targeted Integration Kits are designed to rapidly integrate a user-specified gene of interest (GOI) into preferred sites of integration in either the human, mouse or rat genome. In the human genome the adeno-associat...

MISSION™ shRNA Packaging Vector

Contact Us For questions about the library, pricing and quotes or other concerns, please e-mail us at: MISSIONRNAi@sial.com. MISSION is a trademark of Sigma-Aldrich. Label License. back to top back to MISSION™ Lentiviral Packaging back to Functional Genomics & RNAi

Innovative Products and Tools for Neuroscience Research

Driven by a desire to improve human health for all, we are building a network of discovery – creating connections, scientists-to-scientists and sharing insights, ideas and expertise with the goal of advancing neuroscience research. Whether you are developing innovative predictive models, detecting n...

Single Cell Whole Genome Amplification: Unleashing a World within a Cell

Chad T. Brueck, Deborah L. Vassar, Clyde Brown, Ernie Mueller, Sigma-Aldrich Corp., St. Louis, MO, USA Analyzing genomic DNA at the level of the single cell will provide the ultimate level of variation analysis. Unfortunately, amplifying the picogram quantities of DNA in a single cell has been diffi...

CRISPR on the Brain? Standardized Functional Genomics Tools Advance Neuroscience

Deciphering the genetics of neuroscience has always been challenging. Heterogeneous tissue microenvironments, complex genetic interactions and phenotypes, lack of model systems that accurately mimic the human brain transcriptome – not to mention the blood-brain barrier – make genetic perturbation an...

Targeted Genome Editing Using Engineered Zinc Finger Nucleases

Phil Simmons and Derek Douglas Product Management, Biotechnology Division The determination of complete genome sequences for a wide variety of experimental organisms established a first step in the search for an in-depth understanding of the complex genetic functions that define living entities. Ext...

Targeted Gene RNAi Knockdown Experiments Measured Using AQUA

Richard J. Mehigh, Jeffrey J. Porter, Beth K. Ewing, Justin Wildsmith, Kenneth E. Heuermann, Kelly L. Foster, John G. Dapron, Steven L. Cockrill, William K. Kappel, and Graham B. I. Scott Download pdf version. (1.96 mb PDF) Abstract Introduction Materials Methods Results Conclusions References Abstr...

RNAi Applications Center

Locate Protocols, Literature References and other tools related to Functional Genomics research. Several areas with detailed information include shRNA and siRNA. Note: Much of the application data provided on this page has not been developed by our internal scientists, but is external, user-generate...

Analyzing Properties of Fluorescent Dyes Used for Labeling DNA in Microarray Experiments

BioFiles 2011, 6.3, 9. Dr. Jens Sobek, Catharine Aquino, Dr. Ralph Schlapbach, Functional Genomics Center Zurich, Zurich, Switzerland Cy3 and Cy5 are fluorescent dyes frequently used for microarray analysis. These two dyes have favorable properties, including relatively high fluorescence quantum yie...

Biology and Analytical Chemistry Webinar Guide

Biology Webinar Guide Quality Systems and Regulatory Compliance Drug Discovery Webinar Guide Analytical Webinar Guide Materials Science Webinar Guide • Proteomics • qPCR • CRISPR • Cell Culture • Cell Design Studio • Duolink • RNAi • Regulatory Compliance • Late Stage Functionalization of Drug-Like ...

Current References on RNAi

Looking for current application references in the field of RNAi? Look no further. Listed below are many of the top research articles relevant to RNAi and Functional Genomics research. Articles include shRNA, lentiviral-based systems, delivery to various cell lines and transgenic animals, as well as ...

ZFN Technology

• • Download PDF • The genomes of several organisms, including humans, have been sequenced, yet we have a limited understanding of the functional implications of the identified genes. Extensive analysis is required to understand the function of each gene and put that into the systemic context. This ...

Peptides & Proteins including neuropeptides, hormones, receptors, cytokines, growth factors and kinases.

We offer an extensive portfolio of highly active proteins and peptides, suitable for a wide range of applications to meet all of your research needs. We have thousands of products ranging from neuropeptides and hormones, to receptors, cytokines and growth factors, and kinases. Find these products an...