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8 matches found for impurity profiling

Organic Impurity Profiling Method for Desvenlafaxine Extended Release Tablets Following the United States Pharmacopeia Monograph

Desvenlafaxine also known as O-desmethylvenlafaxine, is a synthetic form of the major active metabolite of venlafaxine. It is an antidepressant drug of the serotonin-norepinephrine reuptake inhibitor (SNRI) class and primarily used in the treatment of major depressive disorder. It was developed by P...

Assay and Organic Impurity Profiling of Droxidopa using a ZIC-HILIC column and UV detection

Droxidopa is a synthetic amino acid precursor, and acts as a prodrug to norepinephrine (noradrenaline) to increase neurotransmitter concentration in the body and the brain. Droxidopa was developed by Sumitomo Pharmaceuticals for the treatment of hypotension, including neurogenic orthostatic hypotens...

Assay and Organic Impurity Profiling of Apixaban using an Ascentis Express C18 column and UV Detection

Apixaban is a selective, orally bioavailable, and reversible inhibitor of free and clot-bound factor Xa (which catalyzes the conversion of prothrombin to thrombin). Apixaban is sold under the tradename Eliquis, and is typically prescribed to lower the risk of stroke and embolism in people with nonva...

UHPLC (Isocratic) Analysis of 14 Cannabinoids on Chromolith® HR RP-18e

instrument Dionex/Thermo Electron Ultimate 3000 HPLC column Chromolith HR RP-18e, 10 cm x 4.6 mm (1.52022) mobile phase [A] 0.1% formic acid in water; [B] 0.1% formic acid in acetonitrile isocratic 30/70 [A]/[B] flow rate 1.5 mL/min pressure 1100 psi (75,8 bar) column temp. 30°C detector UV at 230nm...

UHPLC/MS Analysis of Cannabinoids on Ascentis® Express C18

column Ascentis Express C18, 10 cm x 2.1 mm I.D., 2.0 µm particles (50813-U) column temp. 35 °C mobile phase [A] 0.1% formic acid; [B] 0.1% formic acid in acetonitrile gradient 60% B to 100% B in 10 min flow rate 0.4 mL/min pressure 7200 psi (496 bar) sample 100 ng/mL each in methanol injection 1 µL...

UHPLC/MS Analysis of Ten Cannabinoids on Ascentis® Express RP-Amide

column Ascentis Express RP-Amide, 10 cm x 2.1 mm I.D., 2.0 µm particles (53913-U) column temp. 35 °C mobile phase [A] 0.1% formic acid; [B] 0.1% formic acid in acetonitrile gradient 60% B to 100% B in 10 min flow rate 0.4 mL/min pressure 7600 psi (524 bar) sample 1000 ng/mL each in methanol injectio...

UHPLC Analysis of Cannabinoids on Ascentis® Express C18

column Ascentis Express C18, 10 cm x 2.1 mm I.D., 2.0 µm particles (50813-U) column temp. 35 °C mobile phase [A] 0.1% formic acid; [B] 0.1% formic acid in acetonitrile gradient 50% B to 100% B in 10 min flow rate 0.4 mL/min pressure 6300 psi (434 bar) sample 50 ng/mL each in methanol injection 1 µL ...

UHPLC (Isocratic) Analysis of 14 Cannabinoids on Ascentis® Express C18

instrument Dionex/Thermo Electron Ultimate 3000 HPLC column Ascentis Express C18, 15 cm x 2.1 mm, 2.7 µm mobile phase [A] 0.1% formic acid in water; [B] 0.1% formic acid in acetonitrile isocratic 30/70 [A] / [B] flow rate 0.6 mL/min pressure 6390 psi column temp. 20 °C detector UV at 230nm injection...