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702 matches found for ligands

Enzyme Explorer Key Resources: Lipoprotein Function

Products for Lipoprotein Research Overview Classification of Lipoproteins and the Systemic Pathway of Lipids Apolipoprotein Classification, Properties and Function Plasma & Blood Protein Resource Overview Cholesterol is an essential nutrient required structurally for cell membranes and myelin sheath...

Chiral Diene Ligands for Asymmetric Transformations

• • Download PDF • Dr. Daniel Weibel Dr. Daniel Weibel Product Manager Email: daniel.weibel@sial.com In the last few years, a number of chiral diene ligands have emerged for a variety of asymmetric transformations.1 This powerful new method has proven to be an efficient way for the construction of e...

Cell Signaling & Neuroscience: Ligand Gated Ion Channels

The majority of ion channels fall into two broad categories: voltage-gated ion channels (VGIC) and ligand-gated ion channels (LGIC). The LGIC superfamily of receptors contains an intrinsic ion channel, which undergoes a conformational change following the binding of an extracellular ligand to its si...

Asymmetric Synthesis

The catalytic asymmetric epoxidation of olefins has become the reaction of choice to generate diverse chiral building blocks used in the synthesis of natural products and biologically active molecules. The development of catalysts based on bis(hydroxamic acid) ligands for the vanadium-catalyzed asym...

Cell Signaling & Neuroscience:Voltage-Gated Ion Channels

The majority of ion channels fall into two broad categories: voltage-gated ion channels (VGIC) and ligand-gated ion channels (LGIC). Members of the VGIC superfamily are usually closed at the resting potential of the cell. A change in the membrane potential causes conformational changes that result i...

Heparin Vs Heparin Sulfate Proteoglycans

Related Links • 3D cell culture • 3D hydrogels • HyStem® hydrogels Related Products • Cell culture • 3D cell culture • Brief Summary • Nomenclature • Heparin vs. Heparan Sulfate • Differences between heparin and heparan sulfate • Chemical Structure • Synthesis and Chemical Diversity • Heparan Sulfat...

Organosilanes for Cross-coupling

• • Download PDF • Over the past several years, Pd-catalyzed cross-coupling of silicon compounds has rapidly gained acceptance as a suitable alternative to more commonly known methods such as: Stille (Sn), Kumada (Mg), Suzuki (B), and Negishi (Zn) cross-couplings.1 Organosilicon compounds are easily...

DuPhos and BPE Phospholane Ligands and Complexes

Aldrich ChemFiles 2008, 8.2, 34. In the early 1990s, Burk and coworkers developed new electron-rich C2 symmetric bis(phospholane) ligands. The modular nature of these ligands allowed for variation of both phosphane substituent and backbone structures, leading to an extensive library of ligands for e...

Suzuki Coupling | Aldrich ChemFiles 2006, 6.2, 10.

• • Download PDF • C–C bond formation via the Suzuki–Miyaura reaction is one of the most powerful and thoroughly explored facets of Pdcatalyzed cross-coupling. The boron-based nucleophiles utilized in this reaction offer distinct advantages over other organometallic coupling reagents. Both boronic a...

KIT ligand
Synonyms FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7
Species Human (4254) , Species Rat (60427) , Species Goat (100860807) , Species sheep (443371) , Species domestic guinea pig (100721734) , Species chicken (396028) , Species domestic cat (493937) , Species dog (403507) , Species Horse (100034127) , Species cow (281885)
Summary: This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Solvias Chiral Phosphine Ligands - Toolkit for Asymmetric Catalysis

Sigma-Aldrich, in collaboration with Solvias, is proud to present the Chiral Ligands Kit – the ultimate toolkit for asymmetric catalysis! The kit (Product No. 12000-1KT) is designed to allow rapid screening of chiral catalysts and consists of air-stable, non-hygroscopic, and industrially proven Solv...

An ECM Mimetic Library for Engineering Surfaces to Direct Cell Surface Receptor Binding Specificity and Signaling

Sigma Product Listings The extracellular (ECM) microenvironment, defined by biochemical cues and physical cues, is a deciding factor in a wide range of cellular processes including cell adhesion, proliferation, differentiation, and expression of phenotype specific functions. For this reason, enginee...

Applying ARGET ATRP to the Growth of Polymer Brush Thin Films by Surface-initiated Polymerization

Related Articles • Tools for Performing ATRP • Copper(I)-mediated Living Radical Polymerization in the Presence of Pyridylmethanimine Ligands • Typical Procedures for Polymerizing via ATRP • Applying ARGET ATRP to the Growth of Polymer Brush Thin Films by Surface-initiated Polymerization • ARGET ATR...

Asymmetric Transfer Hydrogenation

The use of transfer hydrogenation to reduce alkenes, carboxyl groups, ketones, or imines has become very popular. Hashiguchi et al. reported the asymmetric transfer hydrogenation of ketones using a catalyst system comprised of ruthenium complexed with a chiral diamine ligand (RuCl(p-cymene)[(S,S)-Ts...

Coupling Small Ligands through Carboxyl Groups via a Spacer Arm

Extracted from Affinity Chromatography Vol. 3: Specific Groups of Biomolecules, GE Healthcare, 2014 The partial structure of EAH Sepharose 4B is shown in Figure 4.10. Fig 4.10. Partial structure of EAH Sepharose 4B. Ligands are coupled in a simple one-step procedure in the presence of a coupling reage...

DuPhos and BPE Phospholane Ligands

Aldrich ChemFiles 2006, 6.8, 3. Asymmetric hydrogenation reactions represent the ideal process for the commercial manufacture of single-enantiomer compounds, because of the ease by which these robust procedures can be scaled up and because of the low levels of byproducts generated in these asymmetri...

Gel Filtration Chromatography

Gel filtration chromatography seprarates proteins, peptides, and oligonucleotides on the basis of size. Molecules move through a bed of porous beads, diffusing into the beads to greater or lesser degrees. Smaller molecules diffuse further into the pores of the beads and therefore move through the be...

Trending Papers

February 2017 Chimera animals have been created to both study drug effects in humans and also the goal of creating organs for use in humans. A recent breakthrough using CRISPR has occurred to knockout an animal fetus’ immune response to human cells. Now that the human cells can flourish in a non-hum...

Solvias Ligands and Complexes

Aldrich Chemistry offers more than 100 Solvias ligands and complexes for applications from asymmetric hydrogenations to cross-coupling reactions. The selected ligands and complexes shown below along with the corresponding enantiomers are now available in quantities of up to 1kg and also at reduced p...

Reactive Silver Inks for High-Performance Printed Electronics

S. Brett Walker,1,2 Bok Yeop Ahn,3* Jennifer A. Lewis1,3,4 1Materials Science and Engineering Department University of Illinois at Urbana-Champaign, Urbana, IL 61801 2Electroninks Incorporated, Champaign, IL 61820 3Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, ...

Advantages of Air-Stable Precatalysts for Amination

Aldrich ChemFiles 2010, 10.1, 8. Dr. Josephine Nakhla Dr. Josephine Nakhla Product Manager Email: josephine.nakhla@sial.com C–N bond forming cross-couplings typically require a palladium (Pd) source along with the associated ligands. Most Pd(0) sources are not air-stable, while the commonly employed...

Product Highlights for Organic and Inorganic Synthesis

NEW! Photocatalysis NEW! Partial PROTACs for Targeted Protein Degradation NEW! AISF: A Stable, Solid Alternative to Sulfuryl Fluoride Gas NEW! Carbohydrate-Catalyzed Enantioselective Alkene Diboration By Application Area Peptide Synthesis • Peptide Coupling Reagents Selection Guide (2017) Cross-Coup...

Coupling through the Primary Amine of a Ligand

Extracted from Affinity Chromatography Vol. 3: Specific Groups of Biomolecules, GE Healthcare, 2014 NHS-activated Sepharose is designed for the covalent coupling of ligands (often antigens or antibodies) containing primary amino groups (the most common form of attachment). The matrix of NHS-activated ...

Sonogashira Kit

Product No. 802301 Compound Catalog No. Equivalents MW Density Amount mmol Kit Components Pd(CH3CN)2Cl2 225657 0.014 259.43 2 mg 0.007 XPhos 638064 0.038 476.72 9.3 mg 0.019 Triethylamine T0886 2.28 101.19 0.726 0.16 mL 1.14 TPGS-750-M 733857 1.002 1.0 mL User Supplied Aryl bromide [ArBr] 1.0 0.50 A...

Glycoprotein Deglycosylation

• • Download PDF • Aparagine-linked (N-linked) and serine/threonine-linked (O-linked) oligosaccharides are major structural components of many eukaryotic proteins. They perform critical biological functions in protein sorting, immune recognition, receptor binding, inflammation, pathogenicity, and ma...

Trost Ligands

• • Download PDF • Palladium-catalyzed asymmetric allylic alkylation (AAA) has proven to be an exceptionally powerful method for the efficient construction of stereogenic centers. In sharp contrast to many other catalytic methods, AAA has the ability to form multiple types of bonds (C–C, C–O, C–S, C...

Webinar: The Modern Catalysis: Academic Discovery to Industrial Application [VIDEO]

Palladium precatalysts are becoming critical components in a robust high-throughput screening platform. The Modern Catalysis: Academic Discovery to Industrial Application webinar has brought together a panel of experts to review the latest catalytic technology from the Buchwald lab and how transform...

Features of Prestige Antibodies® | Biowire Winter 2011

Subscribe to Biowire and eBiowire Biowire Winter 2011 — Knockout Rats — More Effective Pre-Clinical Models Table of Contents • Study Spotlights ○ The Unique Features of Prestige Antibodies® ○ The New Human Protein Atlas • Methods ○ microRNA Target Validation MISSION® 3’UTR Lenti GoClone™ and Human m...

Purification or Removal of Fibronectin

Extracted from Affinity Chromatography Vol. 3: Specific Groups of Biomolecules, GE Healthcare, 2014 Fibronectin is a high-molecular weight glycoprotein found on the surfaces of many cell types and present in many extracellular fluids including plasma. Fibronectin binds specifically to gelatin at or arou...

Suzuki-Miyaura Coupling and a-Arylation

• • Download PDF • Suzuki-Miyaura coupling reactions using a Pd catalyst derived from Q-Phos are highly successful for both electron-poor and electron-rich aryl bromides and chlorides (Table 3).1 As expected, aryl bromides are more reactive, and typically Suzuki couplings with arylboronic acids proc...

Advanced Protocol: How to Customize your TrueGel3D™ Hydrogel

Related Links • TrueGel3D™ Introduction • TrueGel3D™ Slow Gelling Hydrogels Protocol • TrueGel3D™ TRUE1-1KT kit Protocol • TrueGel3D™ Fast Gelling Protocol • TrueGel3D™ Troubleshooting Guide Related Products • 3D cell culture • Cell culture • 3D hydrogels • ECM proteins • 3D Scaffolds The identity a...