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    Search term:"ligands"

    621 matches found for ligands

    Features of Prestige Antibodies® | Biowire Winter 2011

    Subscribe to Biowire and eBiowire Biowire Winter 2011 — Knockout Rats — More Effective Pre-Clinical Models Table of Contents • Study Spotlights ○ The Unique Features of Prestige Antibodies® ○ The New Human Protein Atlas • Methods ○ microRNA Target Validation MISSION® 3’UTR Lenti GoClone™ and Human m...

    MIDA-protected Boronate Esters

    • • Download PDF • Product Manager The Suzuki-Miyaura cross-coupling reaction is one of the most important and highly utilized reactions in organic chemistry, with applications in polymer science as well as in the fine chemicals and pharmaceutical industries. However, some classes of boronic acids a...

    ATRP Polymerization: Complete Tools for the Synthesis of Well-Defined Functionalized Polymers

    Wojciech Jakubowski, Nicolay V. Tsarevsky and Patrick McCarthy ATRP Solutions, Inc., 166 N. Dithridge Street, Suite G4, Pittsburgh, PA 15213 Synthesis of functional polymers via ATRP Functional initiators for ATRP Ligands for highly active ATRP catalysts Synthetic protocol: Example of ICAR ATRP Summ...

    Wnt/β-Catenin Signaling

    Related Products • Antibodies to Wnt Signaling • Wnt signaling markers • 3D Scaffolds • Stem Cell Culture • Stem Cell Protocols • Primary Cell Culture • ECACC Cell Lines • Cell Culture Media and Reagents • Growth Factors • ECM Protein Related Links • Stem Cell Basics • Stem Cell Culture • Stem Cell ...

    Catalysis Guide

    • Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides • Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides • Stereospecific Pd-Catalyzed Cross-Coupling Reactions of Secondary Alkylboron Nucleophiles and Aryl Chlori...

    Thiolated Gold Nanoclusters a new class of Photosensitizers

    Kevin Stamplecoskie, Yong-Siou Chen, Prashant V. Kamat* Radiation Laboratory and Department of Chemistry and Biochemistry University of Notre Dame, Notre Dame, Indiana, USA *Email: pkamat@nd.edu The past several decades have seen major advancements in the synthesis of metal nanomaterials. Most recen...

    Mild Mg – Halogen Exchange

    • • Download PDF • In recent years, substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.1 Typically, the exchange must be performed below room temperature t...

    (+)-Sparteine Surrogate

    Aldrich ChemFiles 2010, 10.1, 6. Until recently, sparteine, a widely used ligand in asymmetric synthesis1 was only commercially available in one enantiomeric form. O'Brien and his coworkers have designed several (+)-sparteine surrogates, which possess most of the threedimensional architecture of (+)...

    Astec CHIROBIOTIC™ T Chiral HPLC Columns

    Astec Products | Technical Resources Ordering Information Features • Complex chiral environment • π-π interactions • Chiral hydrogen bonding sites • Peptide binding site • Inclusion complexation • Multi-modal possibilites • Excellent alternative to crown ether and ligand exchange for amino acids and...

    CD40 ligand
    Synonyms CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L
    Species Human (959) , Species Mouse (21947) , Species Rat (84349) , Species domestic guinea pig (100733664) , Species naked mole-rat (101700616) , Species Zebrafish (793819) , Species cow (282387) , Species Horse (100054624) , Species domestic cat (493850) , Species dog (403468) , Species chicken (395485)
    Summary: The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

    Vasopressin and Oxytocin Receptors

    The pituitary hormones arginine vasopressin (AVP) and oxytocin (OT) are structurally related cyclic nonapeptides that act as hormones and neurotransmitters. Both peptides are synthesized in neurons in the hypothalamus that project to the posterior pituitary from which they are released into the circ...

    Alkyne Hydration | Technical Article

    Aldrich ChemFiles 2009, 9.5, 6. The hydration of alkynes has been extensively studied for more than 100 years. This reation allows access to various carbonyl derivatives starting from alkynes. Nolan and coworkers reported the acid-free catalyzed alkyne hydration using a gold catalyst.1 Nolan has bee...

    Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)

    • • Download PDF • Originally reported by Lal and coworkers in 1999,1 bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor®) has shown remarkable utility in organic synthesis as a thermally stable alternative to (diethylamino)sulfur trifluoride (DAST). Deoxo-Fluor can easily convert alcohols to a...

    DSM MonoPhos™ Family - Aldrich ChemFiles 2008, 8.2, 51.

    Aldrich ChemFiles 2008, 8.2, 51. Feringa and co-workers have developed a diverse array of chiral, monodentate phosphoramidites based on the privileged BINOL platform.1 The MonoPhos™ family has exhibited high levels of enantiocontrol in synthetic transformations ranging from metal-catalyzed asymmetri...

    Cell Signaling & Neuroscience Literature

    • Alzheimer's Disease Pathways poster • Cytoskeleton & Extracellular Matrix brochure • Gene Regulation and Chromatin Modification brochure • Ion Channel Solutions brochure • Ion Channels Technical brochure • Neurodegenerative Diseases brochure • Neuropsychiatric Disorders brochure • Tyrosine Kinases...

    Symmetrical Rf-tagged 1,3-Diketone Ligand

    Triacontafluoro-8,10-heptadecanedione has been described as an symmetrical perfluorinated ligand for transition metal catalyzed oxidations in perfluorinated solvents.[1] back to top 1. Klement, I.; Lütjens, H.; Knochel, P. Angew. Chemie, Int. Ed. Engl. 1997, 26, 1454 back to top

    Custom Synthesis

    Custom Products Submission Form Custom Synthesis is optimal for synthesizing • Chemical reagents • Catalysts and ligands • Building Blocks • Materials for organic electronics • Chemical standards/solutions • Lead-like or drug-like compounds • Chemical Service (Reaction screening, Special packaging, ...

    EGF Signaling: Tracing Cancer's Path

    The epidermal growth factor (EGF) family is a group of structurally related proteins that regulate cell proliferation, migration and differentiation via tyrosine kinase receptors on target cells. The EGF receptor has a cytoplasmic tyrosine kinase domain, a transmembrane domain and an extracellular d...

    Hydroformylation

    Aldrich ChemFiles 2009, 9.2, 9. Despite a long-standing belief that formyl groups cannot be generated at quaternary carbon centers via hydroformylation, Clarke and Roff have developed a method utilizing 1,3,5,7-tetramethyl-6-phenyl-2,4,8- trioxa-6-phosphaadamantane, an air-stable phosphane ligand, w...

    EGFR

    Epidermal growth factor receptor (EGFR), its family members Her-2/ErbB-2, Her-3, Her-4 and their ligands, are involved in over 70% of all cancers. EGFR itself has been implicated in ~30% of all solid human tumors. EGFR is associated not only with the proliferation of tumor cells, but also with enhan...

    Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

    Andrea M. Kasko Department of Bioengineering University of California, Los Angeles 410 Westwood Plaza, 5121 Eng V Los Angeles, CA 90095 United States Email: akasko@ucla.edu Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for divers...

    Alkyne Hydration

    The hydration of alkynes has been extensively studied for more than 100 years. This reaction allows access to various carbonyl derivatives from alkyne precursors. Nolan and coworkers reported alkyne hydration using a gold catalyst. Nolan, a pioneer in the use of N-heterocyclic carbenes (NHCs) as lig...

    Quinoline Ligands for Pd catalyzed C-H activation

    Pd catalyzed C-H activation is a powerful method for installing functional groups onto biologically relevant molecules. However, C(sp3)-H activation has proven quite challenging. Ligand selection is critical for these types of transformations because the ligands tune the metal catalyst’s reactivity ...

    Bis(3,5,3′,5′-dimethoxydibenzylideneacetone)palladium(0)

    Another goal that Pd catalysts must achieve before industrial applications can be realized involves the recovery and reuse of the catalyst, because homogeneous palladium catalysts contaminate products, process equipment, and waste streams necessitating costly clean-up procedures. Furthermore, the lo...

    Acetylcholine Receptors (Nicotinic)

    Nicotinic acetylcholine receptors (nAChRs) constitute a family of ligand-gated channels, originally classified on the basis of their activation by the alkaloid nicotine, with acetylcholine (ACh) being the endogenous ligand. nAChRs are pentameric transmembrane proteins that form cationic channels per...

    Performing a Separation with GE Healthcare Products Based on GST Fusion Proteins

    Related Links • Fractional Precipitation of Affinity Chromatography Samples • Removal of Lipoproteins from Affinity Chromatography Samples • Sample Preparation for Affinity Chromatography • Column Packing and Preparation for Affinity Chromatography • Converting From Linear Fow (cm/hour) to Volumetri...

    Custom-Engineered Cell Lines

    The onset of cancer is generally believed to occur from the accumulation of specific mutations that alter the genetic makeup of the transformed cell1. Some mutations may result in over- or under-expression of the target gene, while other mutations may be as subtle as a single base pair change alteri...

    DSM MonoPhos™ Family - Highly Efficient Privileged Ligands

    Aldrich ChemFiles 2006, 6.4, 15. Product Highlights • Superior enantiocontrol in numerous transformations • High activities at low catalyst loadings • Hydrogenations under low-pressure conditions • Applied in tandem reactions to yield valuable chiral organics Feringa and co-workers have invented a d...

    Proteinase-Activated Receptors

    The search for a functional thrombin receptor, using expression cloning methods, led to the discovery of a G protein-coupled receptor that mediates the actions of thrombin on platelets and endothelial cells. The thrombin receptor, in contrast with other G protein-coupled receptors, lacks a circulati...

    Quorum Sensing Modulators

    Quorum sensing is a chemical communication mechanism used by many common bacteria to initiate group behaviors. It plays an important role in the establishment of infection by pathogens and in mediating certain symbioses.1 As quorum sensing is dependent on small-molecule signals produced by the bacte...

    Cross-coupling in Chemical Synthesis

    Cross-coupling has been an essential reaction for the past 20 years with its utilization increasing exponentially for the last 10 years. It has been used in the synthesis of a variety of products ranging from natural compounds to polymers. Products: • Chem Product Central™ • Catalysts and Ligands • ...