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33 matches found for neurodegenerative_diseases

Predictive Models for Neuroscience using CRISPR [VIDEO]

Related Links • Neuroscience • CRISPR • Latest CRISPR Research Caroline Beckett, the global CRISPR product manager for MilliporeSigma, discusses reagent solutions for creating predictive models for neuroscience research. She notes that many neuroscientists want to be able to create a predictive mode...

EuTc - Hydrogen Peroxide Quantification Agent

Europium-based dye Product number: 02816 for 100 reactions 1. Background Hydrogen peroxide (H2O2) is a reactive metabolic by-product that is a key regulator in a number of oxidative stress-related states. Functioning through NFkB and other factors, hydroperoxide-mediated pathways have been linked to...

Cell Signaling & Neuroscience Literature

• Alzheimer's Disease Pathways poster • Cytoskeleton & Extracellular Matrix brochure • Gene Regulation and Chromatin Modification brochure • Ion Channel Solutions brochure • Ion Channels Technical brochure • Neurodegenerative Diseases brochure • Neuropsychiatric Disorders brochure • Tyrosine Kinases...

Neural Stem Cell FAQs

The use of neural stem cells (NSCs) in biomedical research is becoming increasingly popular, resulting in breakthrough studies rejected the longstanding belief that neuronal tissue is incapable of regeneration. The discovery that neurons, astrocytes, and oligodendrocytes arise from neural stem cells...

BioFiles Volume 7, Number 2 — Neurodegenerative Diseases

BioFiles Volume 7, Number 2 — Neurodegenerative Diseases Download BioFiles v7 n2 (13.0 Mb PDF) Table of Contents • Alzheimer's Disease: Antibodies, Proteins, Peptides and Assays • Huntington's Disease: Antibodies, Proteins, and Peptides • Parkinson's Disease: Antibodies, Proteins, and Peptides Intro...

GSK-3

GSK-3 is a highly conserved family of protein kinases. In humans, two genes encode two distinct, but closely related GSK-3 forms, referred to as GSK-3α and GSK-3β. They display 84% overall identity and 98% identity within their catalytic domain, the main difference between the two coming from an ext...

Acute and Chronic Inflammation: Microglia in Neuroprotection and Neurodegeneration

The term neurodegeneration characterizes a chronic loss of neuronal structure and function leading to progressive mental impairments. The inci­dence of neurodegeneration generally increases with age. However, infectious agents may also induce neuronal death via apoptosis. Years of research have link...

Neurodegenerative Disease Analysis with Duolink® [VIDEO]

As the population ages, neurodegenerative diseases are becoming increasingly prevalent. These diseases bear with them increased health-care costs, caretaker burden, and an urgent research need. Research into the mechanisms of the most prevalent neurodegenerative diseases, such as Alzheimer’s disease...

Neuroscience Videos

View our collection of videos detailing the efforts towards solving the toughest challenges in neuroscience. Microglial Activation: Understanding Neuroinflammation's Origins Working Together to Advance Neuroscience Research A Different Approach to Creating Predictive Models for Neuroscience Making i...

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxidative metabolism of glucose in the mitochondria, superoxide anions (O2 –) are produced as a by-produ...

Biofiles - Life Science Research Product Resource Guide

Solutions for Detection Volume 9 Abstract Pooled shRNA screening using the highly validated MISSION® shRNA library provides a cost-effective method to investigate gene function and identify therapeutic targets. Here, we present data demonstrating the power and ease of use of the pooled shRNA approac...

Pluripotent Stem Cell Culture

Interested in receiving more content like this? Sign up for our Cell Informer newsletter! Human iPS Cell Lines iPSC Reprogramming Kits Pluripotent Stem Cell Culture Media iPSC Differentiation Media iPSC Dissociation Reagents Pluripotent Stem Cell Markers MEF Feeder Cells Stem Cell Culture Protocols ...

Protein Phosphorylation Analysis Tools - Tools for success in analyzing phosphorylation targets!

Tools for success in analyzing phosphorylation targets! Phosphorylation is an important covalent post-translational modification (PTM) in cell signalling pathways. Protein phosphorylation is the reversible addition of a phosphate group to a protein or small molecule catalysed by protein kinases. App...

Trending Papers

February 2017 Chimera animals have been created to both study drug effects in humans and also the goal of creating organs for use in humans. A recent breakthrough using CRISPR has occurred to knockout an animal fetus’ immune response to human cells. Now that the human cells can flourish in a non-hum...

Microglial-induced Neuroinflammation Webinar

Related Links • Neuroscience Home Page • MILLIPLEX® • Duolink® • Antibodies (PDF) Microglia are the brain's resident immune cells, transitioning from resting to activation upon sensing damage or a foreign substance. Activated microglia release a wave of chemical mediators, including chemokines, cyto...

Neuropsychiatric Disorders and Cell Signaling

• Schizophrenia, the most common psychotic disorder, affects ~ 25 million people worldwide and is one of the leading causes of years lived with disability.1 Historically, antipsychotic drug discovery has been serendipitous, resulting in treatment of a subset of symptoms while failing to address othe...

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on cells as a result of increased oxidant generation, decreased antioxidant protection, or failure to r...

Mesenchymal Stem Cell FAQs

Related Content • Mesenchymal Stem Cell Culture • Stem Cell Culture • Stem Cell Protocols • Cell Culture Media • Cell Culture Reagents • 3D Cell Culture • Stericup® Media Filtration • Growth Factors • ECM Proteins • Antibodies • Bioactive Small Molecules • CRISPR Genome Editing Mesenchymal stem cell...

Epigallocatechin Gallate (EGCG) - Cancer Research

(-)Epigallocatechin Gallate Prod. No. E4143 – Minimum 95% Prod. No. E4268 – Minimum 80% Antioxidant that preferentially induces apoptosis in neoplastic cells Epigallocatechin Gallate (EGCG) is an antioxidant polyphenol flavonoid isolated from green tea. Its possible benefit as a nutritional chemopre...

Current References on RNAi

Looking for current application references in the field of RNAi? Look no further. Listed below are many of the top research articles relevant to RNAi and Functional Genomics research. Articles include shRNA, lentiviral-based systems, delivery to various cell lines and transgenic animals, as well as ...

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activity, subcellular localization, association or binding properties of a protein or lipid. Phosphorylatio...

Derivation of Functional Oligodendrocyte Progenitor Cells (OPCs) from Human Neural Stem Cell Lines

Introduction Methods Human Neural Stem Cell Culture Oligodendrocyte Differentiation and Maturation Oligodendrocyte Progenitor Cell Characterization In Vitro Myelination Assay Results Conclusions Frequently Asked Questions Materials Human neural stem cells (hNSCs) have been intensely studied for thei...

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is one of the most important, and complex, systems in the body. The complexity of the nervous system is ...

β-Secretase (BACE1) Activity Assay Kit: A FRET Based Assay Designed for BACE1 Inhibitor Screening

Cell Biology β Secretase (BACE1) Activity Assay Kit: A FRET Based Assay Designed for BACE1 Inhibitor Screening Lisa Prostak, Efrat Barnea, Pnina Yaish and Dorit Zharhary Sigma-Aldrich Corporation Introduction In recent years, the biological processes involved in the pathogenesis of Alzheimer’s disea...

The Role of Inflammation in Neurodegeneration

It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissue injury. The brain and central nervous system (CNS) were once considered sites of immune privilege, ...

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number o...

Lipid Metabolites as Biomarkers

BioFiles Volume 5, Number 7 — Lipid Metabolism Download BioFiles v5 n7 (PDF) Table of Contents • Introduction • Natural Abundance Lipid Metabolites Glycerolipid Metabolsim Glycerophospholipid Metabolism Ether Lipid Metabolism Spingolipid Metabolism Fatty Acid Metabolism Terpenoid Metabolism Steroid ...

Polymersomes for Drug Delivery

Department of Chemical Engineering, Melbourne School of Engineering The University of Melbourne, Parkville 3010 Victoria, Australia *Email: luke.connal@unimelb.edu.au The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine t...

Read the latest developments in CRISPR research

read abstract Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes Adriana CarolinaGonzalez1MichaelaSchweizer2SebastianJagdmann1ChristianBernreuther3ThomasReinheckel4PaulSaftig1MarkusDamme15 23-01-2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late...

Neuroscience Resource and Education Center

Learn how we’re working together, scientist-to-scientist, to solve the toughest challenges facing neuroscience. Webinars • Generation and Use of iPSC-derived Microglia to Study Neurodegenerative Diseases • Microglial Activation: Understanding Neuroinflammation's Origins • Neurodegenerative Diseases:...