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    Search term:"pharmaceutical"

    532 matches found for pharmaceutical

    BRIDP from Takasago - New Ligands for Cross-Coupling Catalysts

    Cross-couplings have been an essential reaction class for the past 20 years. They are used for the synthesis of a plethora of products ranging from drug molecules to polymers. Since the first report of cross-coupling catalysis by Tsuji and Trost, an exponential number of catalytic systems have been ...

    Cyclopropane Reagent in Chemical Synthesis

    Potassium Cyclopropyltrifluoroborate: Cyclopropyl groups are found in a numerous natural products and are increasingly incorporated into pharmaceuticals such as the broad-spectrum antibiotic ciprofloxacin (Figure 1). A common method for installation of a pre-formed cyclopropane ring is through the u...

    cataCXium® - Ligands and Complexes for Efficient Cross-Coupling Reactions

    Introduction Cross-coupling reactions are an important class of catalytic transformations with applications in polymer science as well as in the fine chemicals and pharmaceutical industries. The use of aryl chlorides for these transformations is preferred due to their low cost and their availability...

    Products for Angiogenesis, Antitumor Agents, Cancer Markers, Carcinogens, Chemopreventive Agents

    During the last twenty years our understanding of the biology of cancer has increased dramatically. It is now widely recognized that cancer results from a series of genetic alterations causing a loss of normal growth controls, resulting in unregulated growth, lack of differentiation, apoptosis, geno...

    Webinar: Gene editing partnerships to enhance drug pipeline productivity

    60 minutes Optimising target-based assays and streamlining hit-to-lead processes are key for a productive R&D drug pipeline. Researchers in both the pharmaceutical and biotech industries, as well as in academic environments, are increasingly searching for novel technologies and related services that...

    Solvents Applications and Markets

    Solvents tailored for specific applications and markets can be found by exploring the expansive range of Sigma-Aldrich products. Agro, Food and Beverage Bioanalytical & Biotech Applications Chemical Industry Environmental Analysis Pharmaceutical Applications

    Serine Hydrolase Inhibitors

    The advertised selection of serine hydrolase inhibitors, developed by the Boger group, represents a small, but powerful library of urea-derived molecules that can bind irreversibly to the target enzyme by active site carbamoylation of the catalytic serine.1 There are approximately 240 different huma...

    Webinar: High-capacity drug-delivery systems for cancer therapy based on poly(2-oxazoline)s

    Webinar Title: High-capacity drug-delivery systems for cancer therapy based on poly(2-oxazoline)s You can watch the recorded version of the webinar by clicking the button above. Poly(2-oxazoline) (POx) is a very promising candidate for use in polymer therapeutics. Amphiphilic POx triblock copolymers...

    Certified Reference Materials

    Sigma Aldrich offers a wide range of certified reference materials. With Cerilliant, RTC and Supelco, Sigma-Aldrich offers three in-house manufactured high quality CRM brands all produced under ISO/IEC 17025 and ISO Guide 34 double accreditation. In addition, we distribute certified reference materi...

    lysophosphatidic acid receptor 5
    Synonyms GPR92, GPR93, KPG_010, LPA5
    Species Human (57121) , Species Mouse (381810) , Species Rat (500317) , Species chicken (418279) , Species cow (507598) , Species dog (486724) , Species sheep (101109610) , Species domestic guinea pig (100735335) , Species naked mole-rat (101716148)
    Summary: This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]

    Frequently Asked Questions about Solvents in Hematology & Histology Research

    General Information Tax-Paid Ethanol Physical Properties Application Notes Returnable Containers General Information How do I get specific lot information or CofA for a solvent? A Certificate of Analysis is available by lot for each of our solvents and can be accessed through our Advanced Search Opt...

    Vol 2 No 8

    Vol. 2, No. 8 New Nitrogen-Containing Heterocycles Introduction / 5-Membered Heterocyclic Rings / 6-Membered Heterocyclic Rings Mitsunaobu Reagents / Polymer-Supported Reagents / JandaJels™ / Functionalized Silica Gels Nitrogen-containing heterocyclic compounds are key building blocks used to develo...

    Target Identification & Validation for Early Drug Discovery

    Early stages of drug discovery start with initial steps of target identification and moves to the later stages of lead optimization. Multiple sources including academic research, clinical works and commercial sector help in the identification of a suitable disease target. The chosen target is then u...

    Troubleshooting & Frequently Asked Questions for HybridSPE-PL

    Yes. The HybridSPE-PL Small Volume plate (52794-U) is designed for processing plasma/ serum volumes between 20-40 µL. Larger sample volumes of 100-300 µL should be processed on the standard HybridSPE-PL plate (575656-U). Acetonitrile is a commonly used protein precipitation agent when prepping plasm...

    Sweet annie (Artemisia annua) | Plant Profiler

    Synonyms / Common Names / Related Terms Artemether, Artemisia annua, Artemisia annua essential oil, Artemisia apiacea, artemisia ketone, Artemisia lancea, arteannuin-B, arteether, artemether, artemetin, artemisinic acid, artemisinin, artemotil, artenimol, artesunate, artimesinin, beta-caryophyllene,...

    Hawthorn (Crataegus oxyacanthoides) | Plant Profiler

    Synonyms / Common Names / Related Terms Aubepine, bei shanzha, bianco spino, bread and cheese tree, Cardiplant®, Chinese hawthorn, cockspur, cockspur thorn, crataegi flos, Crataegi folium, Crataegi folium cum flore, Crataegi fructus, Crataegi herba, Crataegisan , Crataegus azaerolus, Crataegus cunea...

    Supel-Select HLB SPE for Pharmaceutical Analysis

    Related Articles UHPLC Analysis of Taxanes Using A Titan C18 Column and UV Detection Fast HPLC Using Fused-Core Particle Technology for Rapid Screening of Pharmaceutical Compounds Metabolites – A Serious Challenge for LC/MS Separations and Usual Detection Techniques Serum Lipidomics Profiling using ...

    Phytochemical Standards

    Sigma-Aldrich’s offering of phytochemical analytical standards consists of natural products ranging from alcohols and phenols, aldehydes and ketones, alkaloids, flavonoids, glucosinolates, and isoprenoids to organic acids and esters, phenylpropanes, quinones, and tannins. These reference substances ...

    Reference Materials and History of BERM Symposia

    ----------------------- BERM home page Contributed by Peter Jenks, F.R.S.C.; member of the BERM 14 Technical Committee BERM: a symposium with its origins in Biological and Environmental chemical metrology has evolved and extended its reach over a 32-year lifespan, and now touches almost every field ...

    Trace Analysis - Ion Chromatography

    Certified Standard Solutions (TraceCERT®) • PRIMUS (Primary Multi-ion Standards) • Multi-ion Standards • Inorganic Anion Standards • Inorganic Cation Standards • Organic Anion Standards • Carbohydrate and Sugar Alkohol Standards Certified Eluent Concentrates • Single Concentrates • Binary Concentrat...

    Rational and Predictable Chemoselective Synthesis of Oligoamines via Buchwald-Hartwig Amination of (Hetero)Aryl Chlorides Employing Mor-DalPhos

    We report our studies on the use of two catalyst systems, based on the ligands BrettPhos and RuPhos, which provide the widest scope for Pd-catalyzed C-N cross-coupling reactions to date. Often low catalyst loadings and short reaction times can be used with functionalized aryl and heteroaryl coupling...

    An Interview with Dr. Hakim Djaballah

    Biowire Spring 2011 — Cell Lines — Models of Disease Subscribe to Biowire and eBiowire Download Biowire Spring 2011 (7.0 Mb PDF) Biowire Spring 2011 Home Dr. Hakim Djaballah - Director of the High-Throughput Screening Facility at the Memorial Sloan-Kettering Cancer Center (MSKCC) in Manhattan, New Y...

    Functional RAFT Polymers for Biomedical Applications

    M. Shahinur Rahman,* Sebastian Grajales Aldrich Materials Science, Sigma-Aldrich Co. LLC *Email: Shahinur.Rahman@sial.com Reversible addition–fragmentation chain transfer (RAFT) polymerization is rapidly moving to the forefront in construction of drug and gene delivery vehicles. The RAFT technique a...

    Quality Assurance and Quality Control

    Documentation and change control adapted to diagnostics and pharmaceutical applications Proligo® Reagents are manufactured under a strict quality system. All key intermediates are controlled with stringent in-process controls and/or quality specifications in order to exercise maximum control on fina...

    Filtration in Dissolution Testing: Improving Throughput and Reducing Variability

    In vitro dissolution testing is used to characterize drug compounds throughout their development. In early drug development it is used to support the choice of a particular formulation. During drug production it is a critical component of the quality control process and is used to assess the changes...

    Sterility Testing by Membrane Filtration

    Related Products • Sterility Testing • Sterility Testing by Direct Inoculation • Culture Media and Rinsing Fluids for Sterility Testing • Sterility Testing Hardware & Accessories For filterable pharmaceutical products, the membrane filtration sterility test is the industry standard, particularly whe...

    Class-Selective Enantiomeric Separation of beta-Androgenic Receptors using CHIROBIOTIC™ T Stationary Phase

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    Metal and Phosphine Mediated Transformations

    Functionalized allyl boronates are useful building blocks in natural product synthesis. Olsson et al. reported the use of a palladium pincer complex in combination with diboronic acid for the boronation of readily available allylic alcohols. Under mild conditions, a variety of allylic alcohols were ...

    Biomatrica® | An innovative alternative to reliance on cold chain logistics

    Biomatrica® offers an innovative alternative to reliance on cold chain logistics Biomatrica products enable researchers in academia, pharmaceutical drug development, and molecular diagnostics to stabilize ship and store biological samples for long periods of time with complete and rapid sample recov...

    Angiogenesis Assays

    Angiogenesis Tube Formation Assays Microfluidic Angiogenesis Assays Endothelial Adhesion, Invasion and Migration Assays Scratch Wound Healing Assays Endothelial Cell Characterization Endothelial Cells and Culture Media References Angiogenesis is the process of generating new capillary blood vessels ...

    Strat-M® Transdermal Diffusion Membrane

    Experience the unmatched predictability of Strat-M® membrane—a synthetic, non-animal based model for transdermal diffusion testing that is predictive of diffusion in human skin without lot-to-lot variability, safety or storage limitations. Designed for transdermal diffusion and safety testing of: • ...