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40 matches found for solid_phase_peptide_synthesis

Traceless Staudinger Ligation

• • Download PDF • Although the previously described methods for Staudinger ligations work well even in biological environments, a modification forming a native amide bond without leaving the unnatural phosphine oxide moiety in the product would be more attractive yet. In 2000, the groups of Bertozz...

Novabiochem® Publication Index

Novabiochem® Innovations Subscribe Now • No. 1/17 - Protocols for the Fmoc SPPS of Cysteine-containing Peptides Novabiochem® Letters Keep abreast of our newest products for peptide synthesis with Novabiochem® Letters. Each product is presented in detail with features and benefits, literature referen...

Acid Halogenation Reagents

The generation of an acid chloride is an obvious way to activate the carboxy group for amide bond formation. However, practical application of acid chlorides in peptide synthesis is restricted, because they are prone to side reactions and racemization. In spite of this disadvantage, acid chlorides a...

Uronium and Guanidinium Salts

• • Download PDF • The special need of SPPS for rapid and highly efficient coupling reagents led to the development of several new reagents starting from BOP (Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate). The HOBt (N-Hydroxybenzotriazole) derived components HBTU and TBTU t...

Protocols for the Fmoc SPPS of Cysteine-containing Peptides

Related Links • Subscribe to Novabiochem Innovations • VIEW PRODUCT LIST Introduction Cysteinyl protection Fmoc SPPS using protected cysteine derivatives Synthesis of cysteinyl peptides Handling of sulfhydryl peptides Disulfide bond formation by oxidation of cysteinyl peptides Reduction of disulfide...

4-(Hydroxymethyl)phenoxyacetic Acid Resins

(81549) These polymer supports show a lability towards trifluoroacetic acid (TFA) similar to Wang resins. Detachment of the final peptide is accomplished using 95% TFA. The amide bond between the “handle” and aminomethyl polystyrene avoids the acid-sensitive benzyl phenyl ether linkage that has been...

Aminoalkylated Resins

Our (aminomethyl)polystyrene resins are prepared by aminomethylation of unsubstituted polystyrene in order to ensure chemically homogeneous supports, free of any reactive chloromethyl groups. Aminoalkylated resins represent an ideal base for the immobilization of linkers for both Boc- and Fmoc-SPPS ...

Staudinger Ligation - Aldrich ChemFiles 2008, 8.1, 7.

• • Download PDF • The reaction between an azide and a phosphine forming an aza-ylide was discovered almost a century ago by Nobel Prize laureate Herrmann Staudinger. It has found widespread application in chemical synthesis, but only recently its value as a highly chemoselective ligation method for...

Base Resins for Peptide Synthesis

The Novabiochem® product line has one of the most extensive ranges of polymer-supports for solid phase peptide synthesis. They range from high-loaded, low swelling for the large scale production of relatively short peptides to high-swelling, low-loaded for the synthesis of long or difficult sequence...

BIOshell™ IgG 1000 Å C4 UHPLC Column for Improved Biomacromolecule Separations

Analytix Reporter Issue 2 | 2018 Products & Related Products • View Product List • BIOshell IgG Columns • Solvents and Blends for LC-MS • LC-MS Mobile Phase Additives • SILu™MAb and SigmaMAb Antibody Standards for Mass Spectrometry Related Links • BIOshell HPLC Columns Related Articles • Analytical ...

Protein and Peptide Polymer Conjugates

1Department of Chemistry, The University of Warwick, Coventry CV4 7AL, U.K. 2Warwick Medical School, The University of Warwick, Coventry CV4 7AL, U.K. 3Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, VIC 3052, Australia *Email: s.perrier@warwick.ac.uk The modification of biomacro...

Fmoc Resin Cleavage and Deprotection

Having successfully synthesized a protected peptide, one is confronted with a difficult task of having to simultaneously detach the peptide from the resin support and remove all the side-chain protecting groups of the amino acid residues to yield the desired peptide. In Fmoc SPPS, this step is norma...

Resins for the Boc-/Bzl-Synthesis of Peptide Acids

Merrifield Resins The classic Merrifield reaction scheme for SPPS starts with an esterification of the protected C-terminal residue onto chloromethylated polystyrene, a standard support for Boc-/Bzl-synthesis of peptide acids.(1-3) The benzyl ester linkage, however, is not sufficiently stable to rep...

Building Blocks for Introducing Post-translational Modified Amino Acids

The Novabiochem® product line has always been at the forefront of the development for methods for the synthesis of peptides containing PTMs, being the first company to provide effective building blocks for synthesis of phosphorylated peptides, and sulfotyrosine and methylated arginine containing pep...

Wang resins Preloaded with N-α-Fmoc-Protected Amino Acids B

TFA-labile Wang resins are standard supports for batch synthesis of peptide acids following the Fmoc-/tBu-protection scheme.(1,2) The Fmoc-amino acids are coupled to the 4-hydroxymethylphenoxyacetic acid linkers in such a way that epimerization and dipeptide formation are minimized. Our preloaded Wa...

Boc Resin Cleavage and Deprotection

The most popular reagent for cleavage of peptides from Boc-based resins is anhydrous HF. Of all the cleavage procedures HF appears to be the most versatile and least harmful to a wide variety of peptides synthesized on Boc-based resins. The major drawback of this procedure remains its highly toxic a...

Rink Amide (RAM) Resins

A broad variety of 4-((2,4-dimethoxyphenyl)(Fmoc-amino)methyl)phenoxyalkyl functionalized supports have been developed for the synthesis of peptide carboxamides.(1, 2) Detachment of peptide amides from these widely used supports can be achieved by treatment with 95% trifluoroacetic acid (TFA). Labil...

Carbodiimides

• • Download PDF • Carbodiimide-mediated peptide coupling remains to the most frequently used technique. As a major advantage, carbodiimides do not require prior activation of the carboxylic acid. Dicyclohexylcarbodiimide (DCC) has been predominantly used and is now well established. Since the gener...

Natural Amino Acid Building Blocks for Peptide Synthesis

With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.1 Today, the most common synthetic approaches to medium and even large peptides follow the Boc/Bzl or Fmoc/tBu solid phase peptide synthesis strategies.2 A convenient list of the ...

Overcoming Aggregation in Solid-phase Peptide Synthesis

The 3D structure, and consequently bioactivity, of individual proteins is largely determined by the primary sequence of its component amino acids. This inherent propensity of peptide chains to form ordered structures is the principle cause of the highly sequence specific variability in synthetic eff...

Multi-Neck Flasks - Glassware Catalog

Filtration • Flat-Bottom • Round-Bottom • Multi-Neck • Schlenk • Septum-Inlet • Accessories On this page: Round-bottom distilling flasks • Jacketed 3-neck flasks Three-neck round-bottom flasks • Solid-phase peptide synthesis flasks Four-neck round-bottom flasks • Five-neck round-bottom flasks Round-...

Peptide Coupling Reagents Selection Guide

The Novabiochem® brand offers one of the most extensive ranges of high-quality coupling reagents for in situ activation on the market. However, with such a plethora of reagents available, the choice of the optimum coupling reagent for a particular application is not always straightforward. Condensat...

Custom Peptides

Related Links • Peptide Portfolio • Quotation Request We provide a comprehensive service portfolio to assist researchers in applications requiring custom peptides and peptide libraries. We routinely synthesize peptides up to 40 amino acids in length (inquire for longer lengths) using state of the ar...

COMU – Safer and More Efficient Peptide Coupling Reagent

Introduction Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitative yields with short reaction times are of utmost importance to make the synthesis of l...

Threading the Molecular Needle: The Importance of Particle Pore Diameter for Biomacromolecule Separations

Recently, the evolution of middle to large biomacromolecules such as peptides or proteins is apparent in the market of pharmaceutical drugs in addition to traditional active ingredients based on small molecules. The use of peptides for clinical purposes has its origins in the 1920’s using insulin an...

ChemFiles 2001-2003 (US)

Welcome to ChemFiles ChemFiles are monthly new product guides in Chemical Synthesis. Each product guide introduces new products and services related to a particular research area of interest. Downloadable pdf versions are shown below. ChemFiles 2009 ChemFiles 2008 ChemFiles 2007 ChemFiles 2006 ChemF...

Brominated Polystyrenes and Bromoalkylated Resins

Brominated polystyrene is a core matrix for the preparation of various functionalized polystyrene resins for SPPS and SPOS. The brominated polymer can be derivatized by Suzuki coupling reactions(1) or lithiation followed by reaction with electrophiles.(2) Acylation of bromoalkylated supports may be ...

Functionalized Polyethylene Glycol (PEG) Reagents

Related Links • PEG Selection Guide The chemical modification of biologically active compounds, such as peptides, proteins, antibody fragments, aptamers, enzymes, and small molecules with polyethylene glycol (referred to as “PEGylation”), is an effective method to tailor molecular properties to part...

Peptide Synthesis Flasks - Sigma-Aldrich Glassware Catalog

Flasks • Funnels • Vessels On this page: Solid-phase peptide synthesis flasks (side joints and a center joint) Solid-phase peptide synthesis flask (Large 85mm top and bottom openings) Solid-phase peptide synthesis flasks Has three S.T. 24/40 side joints and a center joint that varies in size accordi...

COMU—Safer and More Efficient Peptide Coupling Reagent

• • Download PDF • Dr. Matthias Junkers Dr. Matthias Junkers Product Manager Email: matthias.junkers@sial.com Proteins and peptides are ubiquitous in all living systems. The chemical synthesis of peptidic structures for scientific research or drug discovery relies heavily on efficient coupling reage...