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Ubiquitinations(19)
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19 matches found for ubiquitinations

Quality research using BioPerformance Certified Products

Quality research needs quality products. Below you find a short list of BioPerformance Certified products used in various research applications. • Tris 6066 • Trizma Hydrochloride T5941 • PBS P5368 • HEPES H3784 • MES M2933 • Water W3513 • Sodium Phosphate Monobasic S5011 • PIPES P1851 • BES B4554 •...

Autophagy and Mitophagy in Tumor Cell Survival and Death

Autophagy is a highly regulated process that is involved in cell growth, development, and death. In autophagy cells destroy their own cytoplasmic components in a very systematic manner and recycle them. In mammalian cells, autophagy occurs constitutively at basal rates and its primary function is to...

Duolink® PLA Applications

With Duolink® PLA, you can detect, quantify, and visualize protein-protein interactions, post-translational modifications, and low expression protein detection with an easy-to-execute immunodetection protocol that is similar to traditional IF or IHC experiments, but yields far more sensitive signals...

Enzyme Explorer Product Application Index for Proteasome

Determine the fate of your protein. Explore the pathways of intracellular protein degradation with Sigma's comprehensive line of proteasome, calpain and lysosomal proteases. Overview of Ubiquitin and the Proteasome Pathway Product Guide: • Proteasome Pathway • Proteasomes • Calpain • Lysosomal Prote...

Post Translational Analysis

Most proteins contain one or multiple post-translational modifications (PTM) impacting biological relevance. Phosphorylation, glycosylation, sulfation, and ubiquitination modulate functional and structural proteomics research. Analyzing presence and effects requires multiple enabling technologies in...

Detect, Visualize and Quantify Single Post-Translational Modifications

• Duolink® In Situ products enable detection, visualization, and quantification of protein events in tissue and cell samples prepared for microscopy. The in situ PLA® technology, on which these products are based, offers advantages over traditional procedures, as selectivity is increased with dual r...

MAPKKKs

Mitogen-activated protein kinase (MAPK) signaling pathways mediate cellular responses to many stimuli including growth factors, hormones, cytokines and environmental stresses. MAPK pathways can be divided into those that predominantly respond to mitogens and those that predominantly respond to stres...

Epigenetics: DNA Methylation, Chromatin Modification

Epigenetics describes changes that are stable, but potentially reversible alterations in gene expression, that occur without permanent changes in DNA sequence and can still be passed on from generation to generation. Epigenetically controlled genes are activated or repressed without any change in DN...

Chromatin Immunoprecipitation (ChIP) on Unfixed Chromatin

Product lists for commonly used protocols from Cold Spring Harbor Protocols View the protocol "Chromatin Immunoprecipitation (ChIP) on Unfixed Chromatin from Cells and Tissues to Analyze Histone Modifications" at BioSupplynet.com Alexandre Wagschal, Katia Delaval, Maëlle Pannetier, Philippe Arnaud, ...

ubiquitin C
Synonyms HMG20
Species Human (7316) , Species Mouse (22190) , Species Rat (50522) , Species Zebrafish (777766) , Species Horse (100033924) , Species Horse (100059289) , Species dog (610457) , Species chicken (396425) , Species cow (444874) , Species sheep (443016)
Summary: This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

Peptide Modifications: N-Terminal, Internal, and C-Terminal

Peptide Modification Applications Acetylation Increase peptide stability by preventing N-terminal degradation Biotin Commonly used in immunoassays, histocytochemistry, and fluorescence based flow cytometry Dansyl and 2, 4-Dinitrophenyl Fluorescence based assays Fluorescein and 7-methoxycoumarin acet...

Met

The Met family of receptor tyrosine kinases (RTKs) contains two members in mammals, referred to as Met and Ron. Met is the receptor for hepatocyte growth factor/scatter factor (HGF/SF), while Ron is the receptor for macrophage stimulating protein (MSP). In the adult, Met is predominantly expressed i...

Ciulli – Professor Product Portal

Related Links • VIEW PRODUCT LIST • Professor Product Portal • PROTACs Webinar Categories • Partial PROTACs • Chemical Biology • E3 Ubiquitin Ligase • Chemical Probes Professor Product Portal Index Professor Alessio Ciulli The Ciulli group are broadly interested with understanding and exploiting the...

PKC

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as a protein kinase that phosphorylated histone and protamine. Since then, its involvement in many biolo...

Wnt / Beta(β)-Catenin Signaling

Related Products • Antibodies to Wnt Signaling • Wnt signaling markers • 3D Scaffolds • Stem Cell Culture • Stem Cell Protocols • Primary Cell Culture • ECACC Cell Lines • Cell Culture Media and Reagents • Growth Factors • ECM Protein Related Links • Stem Cell Basics • Stem Cell Culture • Stem Cell ...

Retinoic Acid and Gene Expression

• • Download PDF • All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apoptosis, and embryonic development. Retinoic acid and the receptor proteins for which...

Parkinson’s Disease: Misfolding and a Parkin Problem

Parkinson's disease (PD) is a progressive neurological disorder characterized primarily by motor symptoms that include rigidity, hypokinesia and tremor. PD is the second most common neurodegenerative disease and affects about 2-3% of the population 65 years of age and older. Located in the midbrain,...

TRC Library Citations

Publish Sooner When You Partner with the MISSION® shRNA Team! The MISSION® TRC1.5 human and mouse shRNA libraries are the proven performers for small-scale to high-throughput RNAi screening. Below you will find a selection of papers where researchers have published in peer-reviewed journals using th...

Read the latest developments in CRISPR research

read abstract Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes Adriana CarolinaGonzalez1MichaelaSchweizer2SebastianJagdmann1ChristianBernreuther3ThomasReinheckel4PaulSaftig1MarkusDamme15 23-01-2018 Variants in the phospholipase D3 (PLD3) gene have genetically been linked to late...

Immunodetection: Western Blot Troubleshooting

Related Links • Western Blotting (Immunoblotting) Protocol • 30-minute Immunodetection Protocol Using the SNAP i.d.® 2.0 System • Sample Preparation Methods from GE Healthcare • Products for Cell Lysis and Protein Extraction • Western Blotting Home Page • Western Blotting Literature & Resources • We...