New Products for Chemical Synthesis

Fluorinated Building Blocks
Glorius and coworkers developed a cis-selective rhodium-cyclic (alkyl)(amino)carbene (CAAC)-catalyzed hydrogenation of fluorinated arenes and heteroarenes. We are now providing fluorinated building blocks developed using this process. These building blocks offer the ability to fine-tune the polarity, pKA-value, conformation and metabolic stability of compounds and are especially popular in agrochemical and pharmaceutical applications.

VHL Spy Molecules for PROTAC® Research
Targeted protein degradation utilizes E3 ubiquitin ligases to mediate the disposal of target proteins from the cell. One of the most validated E3 ligases is von Hippel-Lindau (VHL), which is recruited by the VH032 ligand. Using VH032 as a template, fluorinated reporter molecules were designed to indicate (or "spy" on) binding of other molecules to VHL through ligand-observed 19F NMR screening, facilitating the identification of novel VHL ligands and VHL-based degraders.

Late-Stage Diversification
Late-stage functionalization is a valuable tool in drug discovery. A new suite of reagents developed by the Li group at McGill University facilitates the late-stage rapid diversification of pharmaceutically relevant compounds. These reagents serve as precursors to alkyl radicals generated under light mediated, redoxneutral and catalyst free conditions for use in the Minisci alkylation of aromatics. J. Am. Chem. Soc. 2017, 139, 40, 14315-14321

Synthetic Reagents

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912522 Adamantanyl 2,2-diiodoacetate ≥95% New
912263 5-Cyano-5H-dibenzo[b,d]thiophenium triflate ≥95% New
ALD00612 (S)-N-(1-(Dimethylamino)-3-phenylpropan-2-yl)acetamide ≥95% New
913383 1,3-Dimethylimidazoyl-2-ylidene borane ≥95% New
912018 7-Methyl-2-phenylimidazo[1,2-a]pyrazin-3(7H)-one ≥95% New
911151 PS-750-M Green Alternative New
911992 TBSAB ≥95% New
912026 5-((Triisopropylsilyl)ethynyl)-dibenzo[b,d]thiophenium triflate ≥95% New

Chemical Biology

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907677 (S,R,S)-AHPC-PEG6-butyl chloride New
910600 (S,R,S)-AHPC-PEG2-butyl CO2H ≥95% New
909823 3-Azido-D-alanine hydrochloride ≥95% New
902675 BocNH-PEG6-acid New
905186 (9-Bromononyl)triphenylphosphonium bromide New
909998 2-(2-((7-(tert-Butoxy)-7-oxoheptyl)oxy)ethoxy)acetic acid ≥95% New
909599 DHSO crosslinker New
903736 Fmoc-Ser(PO(NHPr)2)-OH ≥95% New
910058 2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid ≥95% New
911003 Pomalidomide-PEG2-butyl amine hydrochloride ≥95% New
905208 Pomalidomide-C6-PEG3-butyl amine hydrochloride ≥98% New
910449 Pomalidomide-PEG2-butyl CO2H ≥95% New
910481 Pomalidomide-PEG6-butyl CO2H ≥95% New
901832 Pomalidomide-PEG6-NH2 hydrochloride ≥98% New

Catalysis

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909548 Acetylacetonatocarbonyltriphenylphosphinerhodium(I) New
911984 (2,2′-Bipyridine)diiodonickel(II) New
908835 [1,3-Bis(cyclohexyl)imidazol-2-ylidene][1,3-divinyl-1,1,3,3-tetramethyldisiloxane]platinum(0) New
908819 [1,3-Bis(2,6-diisopropylphenyl)-imidazolidinylidene][1,3-divinyl-1,1,3,3-tetramethyldisiloxane]platinum(0) New
908789 [1,3-Bis(2,6-diisopropylphenyl)imidazol-2-ylidene][1,3-divinyl-1,1,3,3-tetramethyldisiloxane]platinum(0) New
913278 [1,2-Bis(diphenylphosphino)ethane]dibromonickel(II) ≥95% New
913014 [1,3-Bis(diphenylphosphino)propane]dibromonickel(II) ≥95% New
911836 Chloro(1-tert-butyl-1H-inden-1-yl)(tri-tert-butylphosphine)palladium New
908851 Chlorophenylallyl[1,3-bis(2,6-diphenylmethyl)-4-methoxyphenylimidazol-2-ylidene]palladium(II) New
908738 Chlorophenylallyl[1,3-bis(2,6-diphenylmethyl)-4-methylphenyl-2-imidazolylidene]palladium(II) New
908878 (1,5-Cyclooctadiene)[(R)-1-[(R)-2-(2’-diphenylphosphinophenyl)ferrocenyl]-ethyldi-(bis-3,5-trifluoromethylphenyl)phosphine]rhodium(I) tetrafluoroborate New
910732 CyPAd-DalPhos ≥95% New
911402 (CyPAd-DalPhos)NiCl(otol) ≥95% New
910422 Diacetatobis(tricyclohexylphosphine)palladium(II) New
908770 Dichlorobis[(tert-butyl)dicyclohexylphosphine]palladium(II) New
908614 Grubbs Catalyst® M103 New
909165 Hoveyda-Grubbs Catalyst® M711 Umicore New
908053 Platinum on carbon Evonik Noblyst® P2058 5% Pt New
907502 Potassium 5-bromo-1H-indole-1-carbodithioate ≥95% New
905291 Rh2(R-BTPCP)4 New
909556   Rhodium(III) acetate New
905348 Rh2(R-p-Ph-TPCP)4 New
905356 Rh2(R-PTAD)4 New
905259 Rh2(S-PTAD)4 New
905321 Rh2(R-TCPTAD)4 New
905313 Rh2(S-TCPTAD)4 New
912778 sBOX(iPr) ≥95% New
908797 Trimethyl(methylcyclopentadienyl)platinum(IV) New

Building Blocks

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905135 (±)-cis-N-Boc-2-fluorocyclohexylamine ≥95% New