Vol 3 No 1

Vol. 3, No. 1
Strong and Hindered Bases in Organic Synthesis

Introduction / Phosphazene Bases / Verkade's Superbases / Traditional bases
Preservation of Reagents / Schlenk-Type Glassware

Bases are an important class of reagents for synthetic organic chemistry, as in a large amount of reactions the activation of starting materials or reagents through deprotonation is a first step in the synthesis towards new molecules. As different applications and reaction conditions require the use of a specific base, a broad range of inorganic, organic and organometallic bases has been developed and is routinely used. These bases are differentiated by strength, nucleophilicity, steric hindrance and solubility. Special efforts have been invested in optimizing the basicity and in reducing the nucleophilicity of organic bases. These efforts have resulted in several families of interesting molecules.

We offer a broad range of organic bases, from specialized posphazene- and Verkade`s bases, to the traditional alkyl- or aryllithium. The first two classes of exclusive bases are especially suitable for synthetic problems where fine tuning the basicity and the selective sterical hindrance is the key factor to achieve the best results.

Themes discussed in this ChemFile:

  • Phosphazene bases, subdivided into
    • Monomeric phosphazene bases (P1)
    • Dimeric phosphazene bases (P2)
    • Tetrameric phosphazene bases (P4)
  • Verkade's bases
  • Traditional bases, subdivided into
    • amine based traditional bases
    • lithium based traditional bases
    • potassium based traditional bases

We offer a wide range of bases, starting from the traditional MeLi and n-BuLi, to the most specialized, such as phosphazene bases or the Verkade`s bases.

We supply a wide range of products in this field, we also offer Know-How, Quality and Service! A whole team of dedicated chemists is here to help you in your daily work.

Acknowledgment: We kindly thank Prof. Dr. R Schwesinger, Institute for Organic Chemistry and Biochemistry, University of Freiburg, Germany, for his contributions to this ChemFile on phosphazene bases