Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Palladium catalyzed cross-coupling reactions have revolutionized the way in which molecules are constructed. From the fields of organic synthesis and medicinal chemistry, to materials science and polymer chemistry, cross-coupling has impacted multiple areas of science. The field of cross-coupling has grown to include numerous strategies for C-C, C-N, and C-O bond formation, including key reactions such as:

  • Negishi cross-coupling
  • Suzuki cross-coupling
  • Stille cross-coupling
  • Heck cross-coupling
  • Sonogashira cross-coupling
  • Buchwald-Hartwig cross-coupling

While a range of palladium catalysts have been developed for each transformation, often it is difficult to determine which catalyst is best for your desired cross-coupling application. With this in mind, we have put together a convenient guide to assist you when choosing a cross-coupling catalyst. Simply choose which reaction type you are looking to perform and follow the table to see which catalysts are commonly used for that specific application.