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Technology Spotlight

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications across a wide range of therapeutic areas.  However, recent publications often demonstrate the need for a researcher to attenuate or amplify the activity of their target compound without altering the steric bulk of the structure; thus, isosteres of the indole and purine rings have proven very valuable to synthetic and medicinal chemists.

Aldrich Chemistry is pleased to offer a wide variety of these useful building blocks for your research.  Browse through the lists below to find the target compounds you’re looking for.