Chemical Synthesis


Diastereoselective Alkylations
Zinc enolates of propanoic acid derivatives exemplify the high diastereoselectivity and provide crystalline products.5

Oxazolidinone scheme 1

Aldol Additions
Examples of this important class of reactions have demonstraged good diastereoselectivity.5

Synthesis of β-Amino Acid Derivatives
Generation of the Ti enolate at -20 °C, followed by alkylation at 0 °C gives access to a range of N- protected ß-amino acids.5 An example is given below.