CUTAG CPG from Proligo Reagents is an universal CPG, i.e. comprises an universal linker ("UnyLinker" under license from ISIS Pharmaceuticals). It can be employed instead of conventional nucleoside-loaded CPG, in the synthesis of any oligonucleotide sequence, irrespective of the 3'-end nucleoside.

Our CUTAG CPG can be used with the same standard conditions and reagents that are employed for the synthesis of oligonucleotides conducted with nucleoside-loaded CPG. The only differences in the preparation of oligonucleotides using Proligo Reagent′s CUTAG CPG, is that the 3′-base of the oligonucleotide to be synthesized is not attached to the support. This base must be added in the first synthesis cycle on the CUTAG support.
CUTAG CPG can substitute for all conventional DNA and RNA supports. It is compatible with most of the oligonucleotide modifiers described in the literature and can also be employed to produce 3′-modified- or thioated oligonucleotides.

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M403000 CUTAG CPG pore size 1000 Å, 25-35 μmol/g