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Trifunctional Probe Building Blocks

Small-molecule probes are widely used in chemical biology research for target ID/validation and the interrogation of biological systems. In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to facilitate the design and synthetic development of chemical probes. Each contains three components: a connectivity group, a reactive group, and a bioorthogonal handle for downstream applications. Not only does the collection enable simultaneous incorporation of reactive groups, but the connectivity group (e.g. amine) can be leveraged to prepare libraries of probe analogs, allowing the biologist to screen for the optimal probe for a given assay.

To learn more about the building blocks and literature examples of their use, please check out our Technology Spotlight, Trifunctional Probe Building Blocks.

Product #



Molecular Formula

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900750 (4-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone HCl salt ≥95% C22H25NO5 · HCl
900603 (4-(2-(2-Aminoethoxy)ethoxy)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone ≥95% C20H21NO4
900599 (4-(Aminomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone 95% C17H15NO2
900618 3-(3-(Bromomethyl)-5-ethynylphenyl)-3-(trifluoromethyl)-3H-diazirine 95% C11H6BrF3N2
900598 (4-(Bromomethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone ≥95% C17H13BrO2
900605 3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride ≥95% C12H14BrFO2SSi
900859 3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride ≥95% C11H12BrFO2SSi
900683 2-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)ethan-1-amine 95% C7H11N3
900831 3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid C8H10N2O2
900600 3-(Fluorosulfonyl)-5-((trimethylsilyl)ethynyl)benzoic acid ≥95% C12H13FO4SSi
900601 3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride ≥95% C12H13FO3SSi
900865 4-Formyl-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride ≥95% C12H13FO3SSi
900610 Hydroxyl di-benzophenone (PEG)3 alkyne C37H33NO9
900617 (4-(Hydroxymethyl)phenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone ≥95% C17H14O3
900611 (3-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone ≥95% C16H12O3
900615 (4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone ≥95% C16H12O3
900619 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzaldehyde ≥95% C17H12O3
900614 3-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid ≥95% C17H12O4
900602 4-(4-(Prop-2-yn-1-yloxy)benzoyl)benzoic acid ≥95% C17H12O4
900613 5-(4-(4-(Prop-2-yn-1-yloxy)benzoyl)phenoxy)pentanoic acid ≥95% C21H20O5
900858 2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid ≥95% C12H7F3N2O3