Degrader Building Blocks

Degrader Building Blocks for Targeted Protein Degradation

An emerging strategy in drug discovery to access difficult-to-treat diseases is targeted protein degradation. The molecules used in these approaches are often called protein degraders, such as proteolysis targeting chimeras (PROTAC® molecules), which are bifunctional molecules that eliminate target proteins from cells. The Degrader Building Blocks are a collection of crosslinker-E3 ligase ligand conjugates with a pendant functional group for covalent linkage to a target ligand. When used in parallel, Degrader Building Blocks are the easiest way to generate libraries of protein degraders that can be screened for effective degradation of your target from cells.

Degrader Building Blocks are conjugates with the following components:

  • Ligands targeting the E3 ligase Cereblon (CRBN) or von Hippel-Lindau (VHL)
  • Crosslinkers with varied lengths and compositions
  • Conjugation sites with reactivity for common functional groups

Learn more!


Please contact us for more information, bulk inquiries, or a full ChemDraw/sdf file of Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Degrader Building Blocks with Amine Reactivity

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901534 (S,R,S)-AHPC-C6-CO2H hydrochloride
910600 (S,R,S)-AHPC-PEG2-butyl CO2H ≥95%
910554 (S,R,S)-AHPC-PEG6-butyl CO2H ≥95% New
901500 Pomalidomide-C3-CO2H ≥95%
901496 Pomalidomide-C6-CO2H ≥98%
901525 Pomalidomide-C9-CO2H ≥95%
910449 Pomalidomide-PEG2-butyl CO2H ≥95%
910481 Pomalidomide-PEG6-butyl CO2H ≥95%
901527 Pomalidomide-PEG1-CO2H ≥95%
901526 Pomalidomide-PEG2-CO2H 95%
901504 Pomalidomide-PEG3-CO2H ≥95%
901824 Pomalidomide-PEG4-CO2H
901828 Pomalidomide-PEG5-CO2H ≥98%
901829 Pomalidomide-PEG6-CO2H

Degrader Building Blocks with Carboxyl Reactivity

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901850 (S,R,S)-AHPC-PEG5-NH2 hydrochloride
906123 (S,R,S)-AHPC-PEG2-butyl amine hydrochloride
905275 (S,R,S)-AHPC-PEG6-butyl amine hydrochloride ≥95%
905232 (S,R,S)-AHPC-C6-PEG3-butyl amine hydrochloride ≥95%
901511 (S,R,S)-AHPC-PEG3-NH2 hydrochloride ≥95%
901493 (S,R,S)-AHPC-PEG1-NH2 hydrochloride ≥95%
901488 (S,R,S)-AHPC-PEG2-NH2 hydrochloride ≥95%
901848 (S,R,S)-AHPC-PEG4-NH2 hydrochloride ≥95%
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride ≥95%
911801 AHPC-C6-PEG1-C3-PEG1-butyl amine hydrochloride ≥90% New
911739 C5 Lenalidomide-PEG1-NH2 hydrochloride ≥95%
911747 C5 Lenalidomide-PEG3-NH2 hydrochloride ≥95%
911755 C5 Lenalidomide-PEG5-NH2 hydrochloride New
911704 C5 Lenalidomine-C3-NH2 hydrochloride ≥95% New
911712 C5 Lenalidomine-C6-NH2 hydrochloride ≥95% New
911720 C5 Lenalidomine-C9-NH2 hydrochloride ≥95% New
915572 Pomalidomide-dipiperazine-NH2 hydrochloride ≥95% New
911658 Pomalidomide-C3-NH2 hydrochloride ≥95% New
911666 Pomalidomide-C6-NH2 hydrochloride ≥95% New
911003 Pomalidomide-PEG2-butyl amine hydrochloride ≥95%
905224 Pomalidomide-PEG6-butyl amine hydrochloride ≥95%
905208 Pomalidomide-C6-PEG3-butyl amine hydrochloride ≥98%
901516 Pomalidomide-PEG1-NH2 hydrochloride ≥95%
901513 Pomalidomide-PEG2-NH2 hydrochloride ≥95%
901495 Pomalidomide-PEG3-NH2 hydrochloride ≥95%
901830 Pomalidomide-PEG4-NH2 hydrochloride ≥95%
901831 Pomalidomide-PEG5-NH2 hydrochloride
901832 Pomalidomide-PEG6-NH2 hydrochloride ≥98%
913987 Pomalidomide-C6-PEG1-C3-PEG1-butyl amine hydrochloride ≥95% New

Degrader Building Blocks for Click Chemistry

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903957 (S,R,S)-AHPC-PEG1-azide
904813 (S,R,S)-AHPC-PEG2-azide
901503 (S,R,S)-AHPC-PEG1-Alkyne ≥95%
901517 (S,R,S)-AHPC-PEG2-Alkyne ≥95%
901533 (S,R,S)-AHPC-PEG3-Alkyne ≥95%
901851 (S,R,S)-AHPC-PEG4-Alkyne
901855 (S,R,S)-AHPC-PEG5-Alkyne
901873 (S,R,S)-AHPC-PEG6-Alkyne
904651 (S,R,S)-AHPC-PEG3-azide ≥95%
909262 (S,R,S)-AHPC-PEG4-Azide ≥95%
909351 (S,R,S)-AHPC-PEG5-azide ≥98%
909378 (S,R,S)-AHPC-PEG6-Azide ≥95%
910538 (S,R,S)-AHPC-PEG2-butyl alkyne ≥95%
910597 (S,R,S)-AHPC-PEG6-butyl alkyne ≥95%
910546 (S,R,S)-AHPC-C6-PEG3-butyl alkyne ≥95%
905216 (S,R,S)-AHPC-PEG2-butyl azide ≥95%
904864 (S,R,S)-AHPC-PEG6-butyl azide ≥95%
904821 (S,R,S)-AHPC-C6-PEG3-butyl azide ≥95%
905178 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide ≥95%
903825 Pomalidomide-PEG1-azide
903833 Pomalidomide-PEG2-azide
904678 Pomalidomide-PEG3-azide
901523 Pomalidomide-PEG1-Alkyne ≥98%
901529 Pomalidomide-PEG2-Alkyne ≥95%
901531 Pomalidomide-PEG3-Alkyne ≥98%
901833 Pomalidomide-PEG4-Alkyne
901834 Pomalidomide-PEG5-Alkyne ≥95%
901835 Pomalidomide-PEG6-Alkyne
909386 Pomalidomide-PEG4-Azide ≥95%
909394 Pomalidomide-PEG5-azide ≥95%
909408 Pomalidomide-PEG6-azide ≥95%
910503 Pomalidomide-PEG2-butyl alkyne ≥95%
910619 Pomalidomide-PEG6-butyl alkyne ≥95%
910511 Pomalidomide-C6-PEG3-butyl alkyne ≥95.0%
904872 Pomalidomide-PEG2-butyl azide ≥95%
903434 Pomalidomide-PEG6-butyl azide ≥95%
904686 Pomalidomide-C6-PEG3-butyl azide ≥95%
904880 Pomalidomide-C6-PEG1-C3-PEG1-butyl azide ≥95%

Degrader Building Blocks with Sulfuryl Reactivity

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905399 (S,R,S)-AHPC-PEG2-butyl chloride
907677 (S,R,S)-AHPC-PEG6-butyl chloride
905380 (S,R,S)-AHPC-C6-PEG3-butyl chloride ≥95%
905402 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride 95%
904724 Pomalidomide-PEG2-butyl iodide ≥95%
903442 Pomalidomide-PEG6-butyl iodide ≥95%
904708 Pomalidomide-C6-PEG3-butyl iodide ≥95%
906050 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide ≥95%

Degrader Research and Discovery Tools

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913979 Biotin-Thalidomide ≥95% New

E3 Ligase Ligands

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901490 (S,R,S)-AHPC hydrochloride ≥97%
901487 (S,S,S)-AHPC hydrochloride ≥97%
911690 C5 Lenalidomide ≥95%
901558 Lenalidomide ≥95%
901494 N-Methylated pomalidomide ≥98%
SMB00586 Nimbolide from Azadirachta indica, ≥98%
N6287 Nutlin-3 ≥98% (HPLC), powder
SML0580 Nutlin-3a ≥98% (HPLC)
P0018 Pomalidomide ≥98% (HPLC)
T144 (±)-Thalidomide ≥98%, powder
SML1896 VH298 ≥98% (HPLC)