Partial PROTACs

An emerging strategy in drug discovery to access difficult-to-treat diseases is targeted protein degradation. The molecules used in this approach are often called proteolysis targeting chimeras (PROTACs), bifunctional molecules that eliminate target proteins from cells. The Partial PROTACs are a collection of crosslinker-E3 ligase ligand conjugates with a pendant functional group for covalent linkage to a target ligand. When used in parallel, they facilitate streamlined synthesis of PROTACs and the generation of PROTACs libraries for targeted protein degradation.

Partial PROTACs are conjugates with the following components.
  • Ligands targeting the E3 ligase Cereblon (CRBN) or von Hippel–Lindau (VHL)
  • Crosslinkers with varied lengths and compositions
  • Conjugation sites with reactivity for common functional groups

The Partial PROTACs are the easiest way to generate libraries of PROTACs for targeted protein degradation. To conjugate to the Partial PROTACs, our bioactive small molecules portfolio contains bioactive molecules for popular targets. Learn more about Partial PROTACs here.

We recently partnered with the Royal Society of Chemistry to broadcast a webinar featuring PROTACs expert Professor Alessio Ciulli. View the recorded version: Targeted protein degradation using small molecules.

Partial PROTACs with Amine Reactivity

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901534 (S,R,S)-AHPC-C6-CO2H hydrochloride
901500 Pomalidomide-C3-CO2H ≥95%
901496 Pomalidomide-C6-CO2H ≥98%
901525 Pomalidomide-C9-CO2H ≥95%
901527 Pomalidomide-PEG1-CO2H ≥95%
901526 Pomalidomide-PEG2-CO2H ≥98%
901504 Pomalidomide-PEG3-CO2H ≥95%
901824 Pomalidomide-PEG4-CO2H
901828 Pomalidomide-PEG5-CO2H ≥98%
901829 Pomalidomide-PEG6-CO2H

Partial PROTACs with Carboxyl Reactivity

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901850 (S,R,S)-AHPC-PEG5-NH2 hydrochloride
906123 (S,R,S)-AHPC-PEG2-butyl amine hydrochloride New
905275 (S,R,S)-AHPC-PEG6-butyl amine hydrochloride ≥95% New
905232 (S,R,S)-AHPC-C6-PEG3-butyl amine hydrochloride ≥95% New
901511 (S,R,S)-AHPC-PEG3-NH2 hydrochloride ≥95%
901493 (S,R,S)-AHPC-PEG1-NH2 hydrochloride ≥95%
901488 (S,R,S)-AHPC-PEG2-NH2 hydrochloride ≥95%
901848 (S,R,S)-AHPC-PEG4-NH2 hydrochloride ≥95%
901860 (S,R,S)-AHPC-PEG6-NH2 hydrochloride ≥95%
905224 Pomalidomide-PEG6-butyl amine hydrochloride ≥95%
901516 Pomalidomide-PEG1-NH2 hydrochloride ≥95%
901513 Pomalidomide-PEG2-NH2 hydrochloride ≥95%
901495 Pomalidomide-PEG3-NH2 hydrochloride ≥95%
901831 Pomalidomide-PEG5-NH2 hydrochloride New

Partial PROTACs for Click Chemistry

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903957 (S,R,S)-AHPC-PEG1-azide
904813 (S,R,S)-AHPC-PEG2-azide
901503 (S,R,S)-AHPC-PEG1-Alkyne ≥95%
901517 (S,R,S)-AHPC-PEG2-Alkyne ≥95%
901533 (S,R,S)-AHPC-PEG3-Alkyne ≥95%
901851 (S,R,S)-AHPC-PEG4-Alkyne
901855 (S,R,S)-AHPC-PEG5-Alkyne
901873 (S,R,S)-AHPC-PEG6-Alkyne
904651 (S,R,S)-AHPC-PEG3-azide ≥95%
905216 (S,R,S)-AHPC-PEG2-butyl azide ≥95% New
904864 (S,R,S)-AHPC-PEG6-butyl azide ≥95%
904821 (S,R,S)-AHPC-C6-PEG3-butyl azide ≥95%
905178 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl azide ≥95% New
903825 Pomalidomide-PEG1-azide
903833 Pomalidomide-PEG2-azide
904678 Pomalidomide-PEG3-azide
901523 Pomalidomide-PEG1-Alkyne ≥98%
901529 Pomalidomide-PEG2-Alkyne ≥95%
901531 Pomalidomide-PEG3-Alkyne ≥98%
901833 Pomalidomide-PEG4-Alkyne
901834 Pomalidomide-PEG5-Alkyne ≥95%
901835 Pomalidomide-PEG6-Alkyne
909386 Pomalidomide-PEG4-Azide ≥95% New
904872 Pomalidomide-PEG2-butyl azide ≥95%
903434 Pomalidomide-PEG6-butyl azide ≥95%
904686 Pomalidomide-C6-PEG3-butyl azide ≥95%
904880 Pomalidomide-C6-PEG1-C3-PEG1-butyl azide ≥95%

Partial PROTACs with Sulfuryl Reactivity

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905399 (S,R,S)-AHPC-PEG2-butyl chloride
905380 (S,R,S)-AHPC-C6-PEG3-butyl chloride ≥95%
905402 (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride 95%
904724 Pomalidomide-PEG2-butyl iodide ≥95%
903442 Pomalidomide-PEG6-butyl iodide ≥95%
904708 Pomalidomide-C6-PEG3-butyl iodide ≥95%
906050 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide ≥95% New

E3 Ligase Ligands

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901490 (S,R,S)-AHPC hydrochloride ≥97%
901487 (S,S,S)-AHPC hydrochloride ≥97%
901558 Lenalidomide ≥95%
901494 N-Methylated pomalidomide ≥98%
SMB00586 Nimbolide from Azadirachta indica, ≥98%
N6287 Nutlin-3 ≥98% (HPLC), powder
SML0580 Nutlin-3a ≥98% (HPLC)
P0018 Pomalidomide ≥98% (HPLC)
T144 (±)-Thalidomide ≥98%, powder
SML1896 VH298 ≥98% (HPLC)