Non Standard Bases

Several applications of synthetic oligonucleotides are based on nucleosides with alternative heterocycles. Sigma-Aldrich provides phosphoramidites of selected non-standard nucleosides as catalog items and offers custom solution for proprietary monomers.

2′Fluoro Phosphoramidites are used to synthesize oligonucleotides that are more thermally stable and provide increased nuclease resistance.

DMT-2′Fluoro-dA(bz) Phosphoramidite

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A211200 DMT-2′Fluoro-dA(bz) Phosphoramidite C47H51FN7O7P    
A211280 DMT-2′Fluoro-dA(bz) Phosphoramidite C47H51FN7O7P configured for PerkinElmer
configured for Polygen
 
A211230 DMT-2′Fluoro-dA(bz) Phosphoramidite C47H51FN7O7P configured for ABI
 
A21120-HH DMT-2′Fluoro-dA(bz) Phosphoramidite C47H51FN7O7P   pkg of 1 × 100 g A211211-01
pkg of 1 × 500 g A211251-01
pkg of please enquire

DMT-2′Fluoro-dC(ac) Phosphoramidite

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C213200 DMT-2′Fluoro-dC(ac) Phosphoramidite C41H49FN5O8P    
C213280 DMT-2′Fluoro-dC(ac) Phosphoramidite C41H49FN5O8P configured for PerkinElmer
configured for Polygen
 
C213230 DMT-2′Fluoro-dC(ac) Phosphoramidite C41H49FN5O8P configured for ABI
 
C21320-HH DMT-2′Fluoro-dC(ac) Phosphoramidite C41H49FN5O8P   pkg of 1 × 100 g C213211-01
pkg of 1 × 500 g C213251-01

DMT-2′Fluoro-dG(ib) Phosphoramidite

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G211200 DMT-2′Fluoro-dG(ib) Phosphoramidite C44H53FN7O8P    
G211280 DMT-2′Fluoro-dG(ib) Phosphoramidite C44H53FN7O8P configured for PerkinElmer
configured for Polygen
 
G211230 DMT-2′Fluoro-dG(ib) Phosphoramidite C44H53FN7O8P configured for ABI
 

DMT-2′Fluoro-dU Phosphoramidite

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U211280 DMT-2′Fluoro-dU Phosphoramidite C39H46FN4O8P configured for PerkinElmer
configured for Polygen
 
U211200 DMT-2′Fluoro-dU Phosphoramidite C39H46FN4O8P    
U211230 DMT-2′Fluoro-dU Phosphoramidite C39H46FN4O8P configured for ABI
 
U21120-HH DMT-2′Fluoro-dU Phosphoramidite C39H46FN4O8P   pkg of 1 × 100 g U211211-01
pkg of 1 × 500 g U211251-01

DMT-dI Phosphoramidite

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M052080 DMT-dI Phosphoramidite C40H47N6O7P configured for PerkinElmer
configured for Polygen
 
M052000 DMT-dI Phosphoramidite C40H47N6O7P    

DMT-dU Phosphoramidte

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M051080 DMT-dU Phosphoramidite C39H47N4O8P configured for PerkinElmer
configured for Polygen
 
M051000 DMT-dU Phosphoramidite C39H47N4O8P    

DMT-5-Methyl-dC(ac) Phosphoramidite

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M053030 DMT-5-Methyl-dC(ac) Phosphoramidite C42H52N5O8P configured for ABI
 
M053080 DMT-5-Methyl-dC(ac) Phosphoramidite C42H52N5O8P configured for PerkinElmer
configured for Polygen