Over the past several years, the Pd-catalyzed cross-coupling of silicon compounds has rapidly gained acceptance as a suitable alternative to more commonly known methods such as: Stille (Sn), Kumada (Mg), Suzuki (B), and Negishi (Zn) cross-couplings.

In the presence of a fluoride activation source, alkenyldimethylsilanols readily react with both aryl and alkenyl halides to give the coupled adducts in very good yields. Alternatively, the Pd-catalyzed cross-coupling can also be performed under basic activation using TMSOK for in situ generation of a nucleophilic silanolate. The utility of performing the cross-coupling under basic activation lies in the ability to perform the reaction in the presence of fluoride-sensitive silyl protecting groups. Alkynylsilanols are also active coupling partners under similar conditions.

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Molecular Formula

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725986 Trimethylsilanol ≥97.5% (GC) C3H10OSi
673250 Sodium 2-furyldimethylsilanolate C6H9NaO2Si
289094 tert-Butyldimethylsilanol 99% C6H16OSi
380423 Triethylsilanol 97% C6H16OSi
678155 (3,4-Dihydro-2H-pyran-6-yl)dimethylsilanol 95% C7H14O2Si
673269 Sodium dimethylphenylsilanolate hydrate 97% C8H11NaOSi · xH2O
667110 Dimethylphenylsilanol 95% C8H12OSi
667951 (4-Methoxyphenyl)dimethylsilanol 96% C9H14O2Si
495565 Triisopropylsilanol 98% C9H22OSi
669164 (N-Boc-2-pyrrolyl)dimethylsilanol 97% C11H19NO3Si
D213705 Diphenylsilanediol 95% C12H12O2Si
697281 Tris(tert-butoxy)silanol packaged for use in deposition systems C12H28O4Si
697303 Tris(tert-pentoxy)silanol packaged for use in deposition systems C15H34O4Si
143723 Triphenylsilanol 98% C18H16OSi