Phosphine Compounds

Transition-metal-catalyzed cross-coupling is an efficient tool for constructing C–C, C–N and C–O bonds in organic synthesis. Intensive interest has been focused on the development of the most effective ligands that improve catalyst performance. Ligands play a key role in stabilizing and activating the central metal atom and fine-tuning the selectivity of transformation. Phosphines have proven to be the most significant class of ligands for cross coupling. The diversity of applications of monodentate, bidentate, Buchwald, cataCXium®, and Dalphos ligands from Aldrich Chemistry include Negishi, Suzuki, Stille, Heck, Sonogashira, and Buchwald-Hartwig cross-coupling.