Buchwald Ligands

For Buchwald-Hartwig Cross Coupling Reaction

Buchwald ligands are bulky electron-rich dialkylbiaryl phospines and are known to improve reactivity in palladium catalysis. These highly active reagents have been extensively applied in the synthesis of pharmaceuticals, natural products, polymers, and new materials. The structure of the dialkylbiaryl ligand is directly correlated to the efficiency of catalysts containing these ligands. Sigma-Aldrich is proud to offer a series of Buchwald ligands successfully utilized in reactions including Suzuki-Miyaura coupling, amination, amidation, enolate arylation, Sonogashira coupling and C-O bond formation.

Sigma-Aldrich provides the following Buchwald Portfolio of Precatalysts and Ligands, detailing product applications to cross-coupling reactions.
Buchwald Precatalysts and Ligands Guide
Buchwald-Hartwig Amination Reaction
Features of Dialkylbiaryl Phosphine Ligands

Product #

Structure

Name

Formula

Reaction

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768154 AdBrettPhos 95% C43H61O2P  
804967 rac-BINAP-Pd-G3 95% C57H45NO3P2PdS  
718742 BrettPhos 96% C35H53O2P reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Fluorinations
805661 BrettPhos-Pd-G3 GT capsule C48H66NO5PPdS  
804355 BrettPhos Pd G4 C49H68NO5PPdS  
659932 Buchwald Ligands Kit I    
687243 Buchwald Ligands Kit II    
698903 Buchwald Ligands Kit III    
695874 t-BuDavePhos 97% C22H32NP reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
638080 tBuXPhos 97% C29H45P reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Carboxylations
reagent type: ligand
reaction type: Decarboxylations
638099 CyJohnPhos 97% C24H31P reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
reagent type: ligand
reaction type: Hiyama Coupling
reagent type: ligand
reaction type: Methylations
reagent type: ligand
reaction type: Negishi Coupling
reagent type: ligand
reaction type: Oxidations
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
764175 P(Cy3) Pd G3 97% C31H46NO3PPdS  
638021 DavePhos 97% C26H36NP reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Hydroaminations
reagent type: ligand
reaction type: Kumada Coupling
reagent type: ligand
reaction type: Negishi Coupling
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
804959 DavePhos-Pd-G3 95% C39H49N2O3PPdS  
761265 2′-Dicyclohexylphosphino-2-methoxy-1-phenylnaphthalene 97% C29H35OP  
707430 2′-Dicyclohexylphosphino-2,4,6-trimethoxybiphenyl 97% C27H37O3P  
804975 DTBPF-Pd-G3 C39H57FeNO3P2PdS  
731013 JackiePhos 95% C39H37F12O2P reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
638439 JohnPhos 97% C20H27P reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
reagent type: ligand
reaction type: Heck Reaction
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
695262 MePhos 97% C25H33P reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
675938 Me4tButylXphos 96% C33H53P reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
695882 PhDave-Phos 97% C26H24NP reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-C Bond Formation
638072 SPhos 97% C26H35O2P reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Heck Reaction
reagent type: ligand
reaction type: Kumada Coupling
reagent type: ligand
reaction type: Negishi Coupling
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
638064 XPhos 97% Green Alternative C33H49P reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-C Bond Formation
reagent type: ligand
reaction type: Heck Reaction
reagent type: ligand
reaction type: Hiyama Coupling
reagent type: ligand
reaction type: Negishi Coupling
reagent type: ligand
reaction type: Sonogashira Coupling
reagent type: ligand
reaction type: Stille Coupling
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
791016 RockPhos 97% C31H49OP  
663131 RuPhos 95% C30H43O2P reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Negishi Coupling
reagent type: ligand
reaction type: Sonogashira Coupling
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
805653 RuPhos-Pd-G3 GT capsule C43H56NO5PPdS  
804290 RuPhos Pd G4 C44H58NO5PPdS  
805483 SPhos-Pd-G2 GT capsule C38H45ClNO2PPd  
805645 SPhos-Pd-G3 GT capsule C39H48NO5PPdS  
677280 sSPhos C26H34NaO5PS · xH2O reagent type: ligand
reaction type: Suzuki-Miyaura Coupling
730998 tBuBrettPhos 97% C31H49O2P reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: C-X Bond Formation
reagent type: ligand
reaction type: Fluorinations
805688 tBuBrettPhos-Pd-G3 GT capsule C44H62NO5PPdS  
695211 tBuMePhos 97% C21H29P reagent type: ligand
reaction type: Arylations
reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Heck Reaction
reagent type: ligand
reaction type: Reductions
805513 P(tBu)3-Pd-G2 GT capsule C24H37ClNPPd  
805696 tBuXphos-Pd-G3 GT capsule C42H58NO3PPdS  
807869 P(o-Tolyl)3-Pd-G2 GT capsule C33H31ClNPPd  
710342 TrixiePhos 97% C28H31P  
796530 TrixiePhos Pd G3 C41H44NO3PPdS  
900331 VPhos 95% C33H49OP  
794228 N-XantPhos Pd G3 95% C49H40N2O4P2PdS  
805629 XPhos-Pd-G3 GT capsule C46H62NO3PPdS  
804274 XPhos Pd G4 95% C47H64NO3PPdS