Sulfonyl Halides

In a sulfonyl halide, a sulfonyl functional group is singly bonded to a halogen atom (R-SO2-X, where X = halogen). Sigma-Aldrich offers a variety of sulfonyl chlorides, sulfonyl fluorides, and sulfonyl bromides as powerful synthetic building blocks. Sulfonyl halides are acylating agents in which the halogen is the leaving group and the reacting nucleophile is sulfonated. Functionalized sulfonyl chlorides constitute an attractive class of linkers to attach fragments to a scaffold by formation of sulfonamide or sulfonate in drug design, such as in the development of receptor agonists. Sulfonyl halides can be used as radical initiators in Cu-mediated polymerizations. Reductive coupling of sulfonyl chlorides to the corresponding valuable disulfide starting materials constitutes an important synthetic process.

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235962 Trichloromethanesulfonyl chloride 97% CCl4O2S
531413 2,2-Difluoro-2-(fluorosulfonyl)acetic acid 97% C2HF3O4S
259772 Chlorosulfonylacetyl chloride 95% C2H2Cl2O3S
302325 2-Chloroethanesulfonyl chloride 96% C2H4Cl2O2S
D186252 N,N-Dimethylsulfamoyl chloride 99% C2H6ClNO2S
390755 Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 97% C3H3F3O4S
680117 3,3,3-Trifluoropropane-1-sulfonyl chloride 95% C3H4ClF3O2S
SYX00116 3-Chlorothiete 1,1-dioxide AldrichCPR C3H5ClO2S
640573 Cyclopropanesulfonyl chloride 95% C3H5ClO2S
125199 3-Chloropropanesulfonyl chloride 98% C3H6Cl2O2S
303771 1-Propanesulfonyl chloride 97% C3H7ClO2S
242705 2-Propanesulfonyl chloride 97% C3H7ClO2S
CDS008347 2-methoxyethane-1-sulfonyl chloride AldrichCPR C3H7ClO3S
51974 Nonafluoro-1-butanesulfonyl chloride ≥98% C4ClF9O2S
473839 Tetrafluoro-2-(tetrafluoro-2-iodoethoxy)ethanesulfonyl fluoride 97% C4F9IO3S
319732 Perfluoro-1-butanesulfonyl fluoride 96% C4F10O2S
CDS009819 4,4,4-trifluoro-butane-1-sulfonyl chloride AldrichCPR C4H6ClF3O2S
CDS020474 Cyclopropylmethanesulfonyl chloride AldrichCPR C4H7ClO2S
CDS012396 3-chlorosulfonyl-propionic acid methyl ester AldrichCPR C4H7ClO4S
CDS011744 1-chloro-2-(ethylsulfonyl)ethane AldrichCPR C4H9ClO2S
CDS003418 2-butylsulfonyl chloride AldrichCPR C4H9ClO2S
651737 Isobutanesulfonyl chloride 97% C4H9ClO2S
CDS020346 3-Methoxypropane-1-sulfonyl chloride AldrichCPR C4H9ClO3S
656607 Cyclopentanesulfonyl chloride 90% C5H9ClO2S
CDS005988 2-pentyl sulfonyl chloride AldrichCPR C5H11ClO2S
CDS011771 3-methyl-butane-1-sulfonyl chloride AldrichCPR C5H11ClO2S
103764 Pentafluorobenzenesulfonyl chloride 99% C6ClF5O2S
555924 2-Bromo-4,6-difluorobenzenesulfonyl chloride 97% C6H2BrClF2O2S
632856 4-Bromo-2,5-difluorobenzenesulfonyl chloride 97% C6H2BrClF2O2S
558745 4-Bromo-2,6-dichlorobenzenesulfonyl chloride technical grade C6H2BrCl3O2S
555908 2,3,4-Trifluorobenzenesulfonyl chloride 97% C6H2ClF3O2S
759996 2,4,6-Trifluorobenzenesulfonyl chloride 97% C6H2ClF3O2S
CDS002770 2,4,6-Trifluorobenzenesulfonyl chloride AldrichCPR C6H2ClF3O2S
555991 3,4,5-Trifluorobenzenesulfonyl chloride 97% C6H2ClF3O2S
CDS011712 5-chloro-2,4-difluorobenzenesulfonyl chloride AldrichCPR C6H2Cl2F2O2S
667439 2,3,4-Trichlorobenzenesulfonyl chloride 97% C6H2Cl4O2S
680125 2,4,5-Trichlorobenzenesulfonyl chloride 95% C6H2Cl4O2S
555649 2,4,6-Trichlorobenzenesulfonyl chloride 96% C6H2Cl4O2S
554235 4-Bromo-2-fluorobenzenesulfonyl chloride 97% C6H3BrClFO2S
558710 4-Bromo-3-fluorobenzenesulfonyl chloride 97% C6H3BrClFO2S
558729 4-Bromo-2-chlorobenzenesulfonyl chloride 96% C6H3BrCl2O2S
CDS016226 4-bromo-3-chlorobenzenesulfonyl chloride AldrichCPR C6H3BrCl2O2S
548677 2,4-Dibromobenzenesulfonyl chloride 98% C6H3Br2ClO2S
557196 2,5-Dibromobenzenesulfonyl chloride 97% C6H3Br2ClO2S
CDS010592 4-fluoro-3-nitrobenzenesulfonyl chloride AldrichCPR C6H3ClFNO4S
548081 2,4-Difluorobenzenesulfonyl chloride 97% C6H3ClF2O2S
555428 2,5-Difluorobenzenesulfonyl chloride 97% C6H3ClF2O2S
544264 2,6-Difluorobenzenesulfonyl chloride 97% C6H3ClF2O2S
555916 3,4-Difluorobenzenesulfonyl chloride 97% C6H3ClF2O2S
555975 3,5-Difluorobenzenesulfonyl chloride 97% C6H3ClF2O2S
638919 2-Chloro-4-fluorobenzenesulfonyl chloride 95% C6H3Cl2FO2S
558672 3-Chloro-2-fluorobenzenesulfonyl chloride 97% C6H3Cl2FO2S
561827 3-Chloro-4-fluorobenzenesulfonyl chloride 97% C6H3Cl2FO2S
555983 4-Chloro-2-fluorobenzenesulfonyl chloride 97% C6H3Cl2FO2S
558680 5-Chloro-2-fluorobenzenesulfonyl chloride 97% C6H3Cl2FO2S
CDS009590 3-chloro-4-nitrobenzenesulfonyl chloride AldrichCPR C6H3Cl2NO4S
724149 4-Chloro-2-nitrobenzenesulfonyl chloride 97% C6H3Cl2NO4S
C59408 4-Chloro-3-nitrobenzenesulfonyl chloride 96% C6H3Cl2NO4S
546917 2,3-Dichlorobenzenesulfonyl chloride 97% C6H3Cl3O2S
545694 2,4-Dichlorobenzenesulfonyl chloride 97% C6H3Cl3O2S
177547 2,5-Dichlorobenzenesulfonyl chloride 98% C6H3Cl3O2S
545708 2,6-Dichlorobenzenesulfonyl chloride 97% C6H3Cl3O2S
457132 3,4-Dichlorobenzenesulfonyl chloride 95% C6H3Cl3O2S
546933 3,5-Dichlorobenzenesulfonyl chloride 97% C6H3Cl3O2S
146110 3,5-Dichloro-2-hydroxybenzenesulfonyl chloride 99% C6H3Cl3O3S
442844 2-Bromobenzenesulfonyl chloride 97% C6H4BrClO2S
545716 3-Bromobenzenesulfonyl chloride 96% C6H4BrClO2S
108669 4-Bromobenzenesulfonyl chloride 98% C6H4BrClO2S
532711 2-Fluorobenzenesulfonyl chloride 97% C6H4ClFO2S
532738 3-Fluorobenzenesulfonyl chloride 97% C6H4ClFO2S
F6206 4-Fluorobenzenesulfonyl chloride 98% C6H4ClFO2S
222941 4-Iodobenzenesulfonyl chloride 95% C6H4ClIO2S
N11507 2-Nitrobenzenesulfonyl chloride 97% C6H4ClNO4S
254665 3-Nitrobenzenesulfonyl chloride 97% C6H4ClNO4S
272248 4-Nitrobenzenesulfonyl chloride 97% C6H4ClNO4S
170925 4-Nitrobenzenesulfonyl chloride technical grade, 90% C6H4ClNO4S
546925 2-Chlorobenzenesulfonyl chloride 97% C6H4Cl2O2S
546968 3-Chlorobenzenesulfonyl chloride 97% C6H4Cl2O2S
133698 4-Chlorobenzenesulfonyl chloride 97% C6H4Cl2O2S
444642 Benzene-1,3-disulfonyl chloride 97% C6H4Cl2O4S2
108138 Benzenesulfonyl chloride 99% C6H5ClO2S
108111 Benzenesulfonyl chloride 96% C6H5ClO2S
282332 Benzenesulfonyl fluoride 99% C6H5FO2S
CDS011892 4-(aminosulfonyl)benzenesulfonyl chloride AldrichCPR C6H6ClNO4S2
CDS003405 3-Aminobenzenesulfonyl fluoride hydrochloride AldrichCPR C6H7ClFNO2S
656542 Cyclohexanesulfonyl chloride 90% C6H11ClO2S
CBR01810 2-(1,1-Dioxidotetrahydro-3-thienyl)ethanesulfonyl chloride AldrichCPR C6H11ClO4S2
01343 1-Hexanesulfonyl chloride ≥95.0% (GC) C6H13ClO2S
558427 2-Bromo-4-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3BrClF3O2S
558435 2-Bromo-5-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3BrClF3O2S
558613 3-Bromo-5-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3BrClF3O2S
558664 4-Bromo-2-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3BrClF3O2S
558621 4-Bromo-3-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3BrClF3O2S
542954 4-Bromo-2-(trifluoromethoxy)benzenesulfonyl chloride 96% C7H3BrClF3O3S
549088 4-Fluoro-3-cyanobenzenesulfonyl chloride 97% C7H3ClFNO2S
324779 2-Nitro-4-(trifluoromethyl)benzenesulfonyl chloride 98% C7H3ClF3NO4S
558575 4-Nitro-3-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3ClF3NO4S
714496 4-Fluoro-2-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3ClF4O2S
480185 2-Chloro-5-chlorosulfonyl-4-fluorobenzoic acid 98% C7H3Cl2FO4S
638366 2-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride 97% C7H3Cl2F3O2S
CDS018005 2-chloro-5-(trifluoromethyl)benzenesulfonyl chloride AldrichCPR C7H3Cl2F3O2S
CDS010707 4-chloro-3-(trifluoromethyl)benzenesulfonyl chloride AldrichCPR C7H3Cl2F3O2S
638870 2-Chloro-4-cyanobenzenesulfonyl chloride 96% C7H3Cl2NO2S
136387 4-(Fluorosulfonyl)benzoyl chloride technical grade, 90% C7H4ClFO3S
491624 2-(Trifluoromethyl)benzenesulfonyl chloride 97% C7H4ClF3O2S
385417 3-(Trifluoromethyl)benzenesulfonyl chloride C7H4ClF3O2S
565849 4-(Trifluoromethyl)benzenesulfonyl chloride 97% C7H4ClF3O2S
579947 2-(Trifluoromethoxy)benzenesulfonyl chloride 97% C7H4ClF3O3S
386545 4-(Trifluoromethoxy)benzenesulfonyl chloride 98% C7H4ClF3O3S
556157 2-Cyanobenzenesulfonyl chloride 98% C7H4ClNO2S
638358 3-Cyanobenzenesulfonyl chloride 97% C7H4ClNO2S
638331 4-Cyanobenzenesulfonyl chloride 97% C7H4ClNO2S
CDS003205 3-(Chlorosulfonyl)benzoyl chloride AldrichCPR C7H4Cl2O3S
CDS015759 (3,4-difluorophenyl)methanesulfonyl chloride AldrichCPR C7H5ClF2O2S
CDS011776 (3,5-difluorophenyl)methanesulfonyl chloride AldrichCPR C7H5ClF2O2S
760056 3,5-Difluorobenzylsulfonyl chloride 97% C7H5ClF2O2S
552267 4-(Difluoromethoxy)benzenesulfonyl chloride 97% C7H5ClF2O3S
441759 3-(Chlorosulfonyl)benzoic acid 95% C7H5ClO4S
252700 4-(Chlorosulfonyl)benzoic acid 96% C7H5ClO4S
734853 2,4-Dichlorobenzylsulfonyl chloride 97% C7H5Cl3O2S
678627 3,4-Dichlorobenzylsulfonyl chloride 97% C7H5Cl3O2S
224189 4-(Fluorosulfonyl)benzoic acid 95% C7H5FO4S
557153 4-(Bromomethyl)benzenesulfonyl chloride 95% C7H6BrClO2S
734861 4-Bromo-2-methylbenzenesulfonyl chloride 97% C7H6BrClO2S
556009 4-Bromo-3-methylbenzenesulfonyl chloride 97% C7H6BrClO2S
CDS006543 4-Bromobenzylsulfonyl chloride AldrichCPR C7H6BrClO2S
749346 3-Bromo-4-methoxybenzenesulfonyl chloride 97% C7H6BrClO3S
544515 5-Bromo-2-methoxybenzenesulfonyl chloride 97% C7H6BrClO3S
638889 2-Fluoro-5-methylbenzenesulfonyl chloride 97% C7H6ClFO2S
558559 3-Fluoro-4-methylbenzenesulfonyl chloride 97% C7H6ClFO2S
558567 4-Fluoro-2-methylbenzenesulfonyl chloride 97% C7H6ClFO2S
748331 4-Fluoro-3-methylbenzenesulfonyl chloride 97% C7H6ClFO2S
700894 4-Fluorobenzylsulfonyl chloride 97% C7H6ClFO2S
558583 5-Fluoro-2-methylbenzenesulfonyl chloride 97% C7H6ClFO2S
700983 3-Fluoro-4-methoxybenzenesulfonyl chloride 97% C7H6ClFO3S
CDS011394 (4-nitrophenyl)methanesulfonyl chloride AldrichCPR C7H6ClNO4S
694487 2-Methyl-5-nitrobenzenesulfonyl chloride 97% C7H6ClNO4S
375829 2-Nitro-α-toluenesulfonyl chloride 98% C7H6ClNO4S
632864 4-Methyl-3-nitrobenzenesulfonyl chloride 97% C7H6ClNO4S
555932 2-Methoxy-4-nitrobenzenesulfonyl chloride 96% C7H6ClNO5S
678643 2-Chlorobenzylsulfonyl chloride 97% C7H6Cl2O2S
545686 3-Chloro-2-methylbenzenesulfonyl chloride 97% C7H6Cl2O2S
554243 3-Chloro-4-methylbenzenesulfonyl chloride 97% C7H6Cl2O2S
CDS014633 4-chloro-3-methylbenzenesulfonyl chloride AldrichCPR C7H6Cl2O2S
664774 4-Chlorobenzylsulfonyl chloride 97% C7H6Cl2O2S
CDS002526 3-Chloro-4-methoxybenzenesulfonyl chloride AldrichCPR C7H6Cl2O3S
CDS013497 2-chloro-5-(methylsulfonyl)benzenesulfonyl chloride AldrichCPR C7H6Cl2O4S2
566357 m-Toluenesulfonyl chloride 97% C7H7ClO2S
557323 o-Toluenesulfonyl chloride 97% C7H7ClO2S
159719 Phenylmethanesulfonyl chloride 98% C7H7ClO2S
CDS006998 4-(methylthio)benzenesulfonyl chloride AldrichCPR C7H7ClO2S2
CDS007595 2-methoxybenzene sulfonyl chloride AldrichCPR C7H7ClO3S
556165 3-Methoxybenzenesulfonyl chloride 96% C7H7ClO3S
M10204 4-Methoxybenzenesulfonyl chloride 99% C7H7ClO3S
CDS007575 2-methylsulfonylbenzenesulfonyl chloride AldrichCPR C7H7ClO4S2
557315 4-(Methylsulfonyl)benzenesulfonyl chloride 97% C7H7ClO4S2
117455 p-Toluenesulfonyl fluoride 98% C7H7FO2S
40486 Heptadecafluoro-1-octanesulfonyl chloride technical, ≥90% (T) C8ClF17O2S
319724 Perfluoro-1-octanesulfonyl fluoride 95% (sum of isomers) C8F18O2S
549002 2,5-Bis(trifluoromethyl)benzenesulfonyl chloride 97% C8H3ClF6O2S
519367 3,5-Bis(trifluoromethyl)benzenesulfonyl chloride 97% C8H3ClF6O2S
760560 3-trifluoromethylbenzylsulfonyl chloride 97% C8H6ClF3O2S
700886 4-(Trifluoromethyl)benzylsulfonyl chloride 97% C8H6ClF3O2S
150525 trans-β-Styrenesulfonyl chloride 97% C8H7ClO2S
CDS000777 3-Acetylbenzenesulfonyl chloride AldrichCPR C8H7ClO3S
00933 4-Acetylbenzenesulfonyl chloride ≥95.0% (AT) C8H7ClO3S
724254 1,4-Benzodioxan-6-sulfonyl chloride 95% C8H7ClO4S
CDS008350 2-(4-fluorophenoxy)ethanesulfonyl chloride AldrichCPR C8H8ClFO3S
CDS013400 2-fluoro-4,5-dimethoxybenzenesulfonyl chloride AldrichCPR C8H8ClFO4S
112747 N-Acetylsulfanilyl chloride 98% C8H8ClNO3S
714453 2,4-Dimethylbenzenesulfonyl chloride 97% C8H9ClO2S
CDS000977 3,4-Dimethylbenzenesulfonyl chloride AldrichCPR C8H9ClO2S
552240 3,5-Dimethylbenzenesulfonyl chloride 97% C8H9ClO2S
664766 4-Methylbenzylsulfonyl chloride 96% C8H9ClO2S
CDS013368 (3-methoxyphenyl)methanesulfonyl chloride AldrichCPR C8H9ClO3S
CDS006831 4-methoxy-3-methyl-benzenesulfonyl chloride AldrichCPR C8H9ClO3S
552232 2,5-Dimethoxybenzenesulfonyl chloride 98% C8H9ClO4S
CDS017967 4-[(dimethylamino)sulfonyl]benzenesulfonyl chloride AldrichCPR C8H10ClNO4S2
374199 1-Octanesulfonyl chloride 97% C8H17ClO2S
760064 4-(Trifluoromethylsulfonyl)phenylacetic acid 97% C9H7F3O4S
CBR01768 4-Oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-7-sulfonyl chloride AldrichCPR C9H8ClNO3S2
749303 Indan-5-sulfonyl chloride 97% C9H9ClO2S
CDS010641 4-(acetylamino-methyl)-benzenesulfonyl chloride AldrichCPR C9H10ClNO3S
CDS009227 4-acetylamino-3-methyl-benzenesulfonyl chloride AldrichCPR C9H10ClNO3S
M7707 2-Mesitylenesulfonyl chloride 99% C9H11ClO2S
556149 4-Isopropylbenzenesulfonyl chloride technical grade C9H11ClO2S
539384 4-N-Propylbenzenesulfonyl chloride C9H11ClO2S
776718 3-Diazo-3,4-dihydro-4-oxonaphthalene-1-sulfonyl chloride 97% C10H5ClN2O3S
CDS012043 5-bromo-naphthalene-1-sulfonyl chloride AldrichCPR C10H6BrClO2S
CDS005310 5-chloronaphthalene-1-sulfonyl chloride AldrichCPR C10H6Cl2O2S
CDS003604 6-chloro-2-naphthyl sulfonyl chloride AldrichCPR C10H6Cl2O2S
CDS002010 2,7-Naphthalenedisulfonyl dichloride AldrichCPR C10H6Cl2O4S2
235881 1-Naphthalenesulfonyl chloride 97% C10H7ClO2S
133361 2-Naphthalenesulfonyl chloride 99% C10H7ClO2S
739820 2-Phthalimidoethanesulfonyl chloride 95% C10H8ClNO4S
CDS001967 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride AldrichCPR C10H11ClO2S
CDS002428 4-Isobutylbenzenesulfonyl chloride AldrichCPR C10H13ClO2S
CDS013590 4-N-butylbenzenesulfonyl chloride AldrichCPR C10H13ClO2S
269670 4-tert-Butylbenzenesulfonyl chloride 98% C10H13ClO2S
575518 3-(4-Methoxyphenoxy)-1-propanesulfonyl chloride 98% C10H13ClO4S
301957 10-Camphorsulfonyl chloride 98% C10H15ClO3S
CDS001203 1-Decanesulfonyl chloride AldrichCPR C10H21ClO2S
CDS010224 5-formylamino-naphthalene-1-sulfonyl chloride AldrichCPR C11H8ClNO3S
CDS008614 6-methoxynaphthalene-2-sulfonyl chloride AldrichCPR C11H9ClO3S
CDS010736 [4-(tert-Butyl)phenyl]methanesulfonyl chloride AldrichCPR C11H15ClO2S
CDS002177 5-tert-Butyl-2-methyl-benzenesulfonyl chloride AldrichCPR C11H15ClO2S
565369 Pentamethylbenzenesulfonyl chloride 97% C11H15ClO2S
724157 4′-Chlorobiphenyl-4-sulfonyl chloride 97% C12H8Cl2O2S
748447 4-(2-Chlorophenoxy)benzenesulfonyl chloride 95% C12H8Cl2O3S
124818 Biphenyl-4,4′-disulfonyl chloride 97% C12H8Cl2O4S2
CDS008675 biphenyl-2-sulfonyl chloride AldrichCPR C12H9ClO2S
536938 Biphenyl-4-sulfonyl chloride C12H9ClO2S
700878 4-Phenoxybenzenesulfonyl chloride 97% C12H9ClO3S
CDS005595 4-(Acetylamino)-1-naphthalenesulfonyl chloride AldrichCPR C12H10ClNO3S
CDS005336 5-acetamidonaphthalene-1-sulfonyl chloride AldrichCPR C12H10ClNO3S
CDS002167 4-Cyclohexylbenzenesulfonyl chloride AldrichCPR C12H15ClO2S
CDS001450 1-Dodecanesulfonyl chloride AldrichCPR C12H25ClO2S
306835 4,4′-Methylenebis(benzenesulfonyl chloride) 97% C13H10Cl2O4S2
737364 4′-Methylbiphenyl-4-sulfonyl chloride 95% C13H11ClO2S
CDS005775 [3-(4-methoxyphenyl)phenyl]sulfonylchloride AldrichCPR C13H11ClO3S
737380 4′-Methoxybiphenyl-4-sulfonyl chloride 95% C13H11ClO3S
CDS012859 4-(benzyloxy)benzene-1-sulfonyl chloride AldrichCPR C13H11ClO3S
CDS011405 5-diethylamino-naphthalene-1-sulfonyl chloride AldrichCPR C14H16ClNO2S
CDS017847 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthalenesulfonyl chloride AldrichCPR C14H19ClO2S
119490 2,4,6-Triisopropylbenzenesulfonyl chloride 97% C15H23ClO2S
H6762 1-Hexadecanesulfonyl chloride 98% C16H33ClO2S
CDS000136 5-(Dibutylamino)-1-naphthalenesulfonyl chloride AldrichCPR C18H24ClNO2S