Nucleoside Chemistry

Sigma-Aldrich offers a collection of useful building blocks and modified nucleosides and nucleotides for applications in oligo synthesis and beyond. Nucleosides are the basic structural units that make up nucleic acids (DNA and RNA), which are responsible for encoding, transmitting and expressing genetic information in all living things. Oligonucleotide synthesis outside of biological systems is the chemical synthesis of nucleic acids of a predetermined sequence that may contain nucleosides beyond those that are naturally occurring. The ability to incorporate non-natural nucleosides into nucleic acids has led to many research uses such as:
  • sequence detection
  • hydrolysis resistance
  • sequencing
  • enzyme inhibition

Nucleoside chemistry in general has been able to produce non-natural analogs that have been useful in medicine with chemotherapeutic and antiviral applications such as reverse transcriptase inhibition. Our selection of unnatural bases, nucleoside derivatives and intermediates will provide you with a useful starting point for your oligo synthetic or nucleoside analog synthesis needs.

Learn More about Oligonucleotide Synthesis
Custom Oligonucleotide Synthesis for Commercial Manufacturing
Custom Oligos