Peptide Chemistry | Peptide Synthesis

Amino Acid Building Blocks, Resins & Coupling Reagents for Solution- and Solid-Phase Peptide Synthesis

Peptides play a crucial role in fundamental physiological and biochemical processes and are essential to many aspects of biomedical research especially as the pharmaceutical industry continues to shift more toward biologicals for new drug candidates. Peptide synthesis continues to be an important and growing area of chemical biology research.

Peptide synthesis is based on three main reactions: 1. a reaction in which a protected animo acid becomes deprotected, 2. a parallel reaction that prepares the next amino acid to be added to the peptide by deprotecting the acid functionality and activating the amino acid, and 3. the coupling reaction that forms the final peptide with amide functionality. In step 2, the amino acid is activated with a number of reagents. These react with the carboxylic acid in the amino acid to make the activated form suitable to enter the coupling reaction. After one round of peptide synthesis, this process can be repeated to add more amino acids until the desired peptide is achieved.

In solid-phase peptide synthesis, the peptide is grown on a polymeric bead or resin. After a successful result, the peptide is usually cleaved from the resin.

We are proud to provide you with more than 2,700 products related to this field such as all the necessary tools for solution- and solid-phase peptide synthesis. This includes over 2,100 natural and unnatural amino acid building blocks with varying protecting groups such as Fmoc, Boc and Cbz among others. We also offer a variety of solid phase resins, coupling reagents and postsynthetic modification compounds to help provide you with a comprehensive offering for your peptide synthesis needs.

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Related Resources
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Chemical synthesis homepage
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