Thioureas

Thioureas are organosulfur compounds structurally similar to ureas, except the oxygen atom is replaced by a sulfur atom to constitute the S=C(NH2)2 moiety. Jacobsen‘s research group has developed a range of chiral thioureas that are versatile and effective organocatalysts. A range of latent nucleophiles can be added to mostly imine-type electrophiles in excellent enantiomeric excesses and, in general, with a broad substrate scope. Thiourea derivatives represent a promising class of anticancer agents because of their inhibitory activity against protein tyrosine kinases (PTKs), human sirtuin type proteins (SIRT1 and SIRT2), topoisomerase II8 and DNA repair synthesis. These enzymatic inhibitory activities coupled with the antiviral, antimalarial, antibacterial and antiinflammatory activities of thioureas have therefore attracted considerable pharmaceutical interest in thiourea derivatives as an important pharmocophore in synthetic medicinal chemistry.

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Jacobsen Thioureas

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T8656 Thiourea ACS reagent, ≥99.0% CH4N2S
M84607 N-Methylthiourea 97% C2H6N2S
M84445 S-Methylisothiourea hemisulfate salt 98% C2H6N2S · 0.5 H2SO4
334677 2-Imino-4-thiobiuret 99% C2H6N4S
A22858 Acetylthiourea 99% C3H6N2OS
03940 2-Imidazolidinethione purum, ≥98.0% (HPLC) C3H6N2S
391964 1,2-Dimethyl-2-thiopseudourea hydriodide 98% C3H8N2S · HI
D188700 N,N′-Dimethylthiourea 99% C3H8N2S
04890 N-Ethylthiourea purum, ≥98.0% (N) C3H8N2S
252530 N-Ethylthiourea 99% C3H8N2S
A54601 2-(2-Aminoethyl)isothiourea dihydrobromide 99% C3H9N3S · 2HBr
108804 N-Allylthiourea 98% C4H8N2S
CDS017065 (4-thioxo-[1,3,5]triazinan-1-yl)-acetic acid AldrichCPR C5H9N3O2S
D100900 N,N′-Diethylthiourea 98% C5H12N2S
115169 Tetramethylthiourea 98% C5H12N2S
466476 1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudourea 97% C6H10N2O4S
592765 N-Boc-thiourea 97% C6H12N2O2S
598143 N-(2,4,6-Trichlorophenyl)thiourea 97% C7H5Cl3N2S
CDS003475 1-(2,3-dichlorophenyl)-2-thiourea AldrichCPR C7H6Cl2N2S
CDS001151 N-(3,5-Dichlorophenyl)thiourea AldrichCPR C7H6Cl2N2S
654833 (2,3-Difluorophenyl)thiourea 97% C7H6F2N2S
654841 (2,4-Difluorophenyl)thiourea 97% C7H6F2N2S
654868 (2,5-Difluorophenyl)thiourea 97% C7H6F2N2S
654876 (2,6-Difluorophenyl)thiourea 97% C7H6F2N2S
586986 1-(2-Bromophenyl)-2-thiourea C7H7BrN2S
CDS004710 1-(3-bromophenyl)-2-thiourea AldrichCPR C7H7BrN2S
CDS003282 1-(4-chlorophenyl)-2-thiourea AldrichCPR C7H7ClN2S
CDS003641 (2-Fluorophenyl)thiourea AldrichCPR C7H7FN2S
654825 (3-Fluorophenyl)thiourea 97% C7H7FN2S
632945 (4-Fluorophenyl)thiourea 97% C7H7FN2S
CDS004474 1-(3-nitrophenyl)-2-thiourea AldrichCPR C7H7N3O2S
199370 1-(4-Nitrophenyl)-2-thiourea 98% C7H7N3O2S
P7629 N-Phenylthiourea ≥98% C7H8N2S
P5272 N-Phenylthiourea Grade II, ≥90% (HPLC) C7H8N2S
222909 N-Phenylthiourea 97% C7H8N2S
D126802 1,3-Diisopropyl-2-thiourea 99% C7H16N2S
654736 [4-Bromo-2-(trifluoromethyl)phenyl]thiourea 97% C8H6BrF3N2S
632937 [3-(Trifluoromethyl)phenyl]thiourea 97% C8H7F3N2S
654760 [4-(Trifluoromethyl)phenyl]thiourea 97% C8H7F3N2S
CDS001114 N-[2-(Trifluoromethyl)phenyl]thiourea AldrichCPR C8H7F3N2S
654744 (4-Cyanophenyl)thiourea 97% C8H7N3S
CDS003990 1-(3-cyanophenyl)-2-thiourea AldrichCPR C8H7N3S
CDS004778 1-(3,4-Methylenedioxyphenyl)-2-thiourea AldrichCPR C8H8N2O2S
560154 1-(3-Carboxyphenyl)-2-thiourea 96% C8H8N2O2S
CDS015865 N-(1H-indazol-5-yl)thiourea AldrichCPR C8H8N4S
CDS016621 N-(1H-indazol-6-yl)thiourea AldrichCPR C8H8N4S
CDS016630 N-(1H-indazol-7-yl)thiourea AldrichCPR C8H8N4S
CDS004649 2-bromo-4-methylphenylthiourea AldrichCPR C8H9BrN2S
CDS004653 4-bromo-2-methylphenylthiourea AldrichCPR C8H9BrN2S
361321 1-(2-Methoxyphenyl)-2-thiourea 99% C8H10N2OS
251038 2-Benzyl-2-thiopseudourea hydrochloride 98% C8H10N2S · HCl
CDS004475 (4-acetylphenyl)thiourea AldrichCPR C9H10N2OS
CDS003285 1-(3-acetylphenyl)-2-thiourea AldrichCPR C9H10N2OS
CDS008463 N-(4-thioureido-phenyl)-acetamide AldrichCPR C9H11N3OS
CDS004928 1-(3-methoxybenzyl)-2-thiourea AldrichCPR C9H12N2OS
654817 (3,5-Dimethylphenyl)thiourea 97% C9H12N2S
CDS003814 1-(2-ethylphenyl)-2-thiourea AldrichCPR C9H12N2S
CBR01175 N-Benzyl-N-methylthiourea AldrichCPR C9H12N2S
CDS004712 1-[4-(dimethylamino)phenyl]-2-thiourea AldrichCPR C9H13N3S
D49598 N,N′-Dibutylthiourea 97% C9H20N2S
CDS004484 1-(3-ethoxycarbonylphenyl)-2-thiourea AldrichCPR C10H12N2O2S
CDS004518 1-(4-ethoxycarbonylphenyl)-2-thiourea AldrichCPR C10H12N2O2S
CDS011683 2,3-Dihydro-1H-inden-5-ylthiourea AldrichCPR C10H12N2S
417009 S-(4,5-Dimethoxy-2-nitrobenzyl)isothiouronium bromide 97% C10H14BrN3O4S
CDS004798 1-(3-Phenylpropyl)-2-thiourea AldrichCPR C10H14N2S
CDS019017 5-Thioxo-1,4,5,6-tetrahydro-3H-furo[3,4-d][1,3]benzodiazepin-3-one AldrichCPR C11H8N2O2S
CDS018968 5-Phenyl-6-thioxo-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-d]pyrimidin-4-one AldrichCPR C11H8N4OS
531820 N,N′-Di-Boc-thiourea 97% C11H20N2O4S
CDS014930 1-(2-methylbut-3-yn-2-yl)-3-phenylurea AldrichCPR C12H14N2O
CDS011743 2-Mercapto-3-(3-methoxy-propyl)-3H-quinazolin-4-one AldrichCPR C12H14N2O2S
CDS001141 N-(4-Phenoxyphenyl)thiourea AldrichCPR C13H12N2OS
CDS019020 9-Ethoxy-5-thioxo-1,4,5,6-tetrahydro-3H-furo[3,4-d][1,3]benzodiazepin-3-one AldrichCPR C13H12N2O3S
T28355 N,N′-Diphenylthiourea 98% C13H12N2S
CDS011708 2-Mercapto-3-(2-methoxy-phenyl)-3H-quinazolin-4-one AldrichCPR C15H12N2O2S
131091 1,3-Di-p-tolyl-2-thiourea 97% C15H16N2S
CDS005262 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea AldrichCPR C17H21F6N3S
458783 1,3-Bis(benzyloxycarbonyl)-2-methyl-2-thiopseudourea 95% C18H18N2O4S
488631 2-Benzyl-1,3-bis(tert-butoxycarbonyl)-2-thiopseudourea 98% C18H26N2O4S