Morpholines are six-membered heterocycles featuring both amine and ether functional groups. Substituted morpholine derivatives are the core of various natural products and biologically active compounds. This class of compounds has found important applications in pharmaceuticals and in agricultural use. Chiral morpholine derivatives have found numerous applications in asymmetric synthesis as chiral auxiliaries as well as chiral ligands. Morpholine derivatives from synthesis and natural products have exhibited activity as antidepressants, appetite suppressants, antitumor agents, antioxidants, antibiotics, selective α1-agonists in the treatment of dementia and other central nervous system (CNS) disorders characterized by symptoms of noradrenergic insufficiency, as well as potent long acting human neurokinin-1 (hNK-1) receptor antagonists. Morpholines have several industrial applications, such as corrosion inhibitors, optical bleaching agents, and in textile dying, and fruit preservation.

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