Oxadiazoles

Oxadiazoles are five-membered heterocyclic aromatic compounds consisting of one oxygen atom, two nitrogen atoms and two carbon atoms. Depending on the placement of the nitrogens in the ring, several isomers exist such as 1,2,4-; 1,2,5-; and 1,3,4-oxadiazole. Oxadiazoles form a major class of compounds with a heterocyclic nucleus for drug development and were among the first effective chemotherapeutic and antibiotic agents. Interest in oxadiazoles ranges from medicinal chemistry to the polymer industry. Oxadiazoles have antibacterial, anti-inflammatory, anticonvulsant, anticancer, antitubercular, anti-diabetic, antihelmintic, and analgesic CNS depressant activities, among others. Due to their broad biological activity potentials, the synthesis of oxadiazole derivatives is of interest to medicinal chemists working in drug development.

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Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)

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749524 3,4-Diaminofurazan 97% C2H4N4O
718130 2-Amino-5-(trifluoromethyl)-1,3,4-oxadiazole 97% C3H2F3N3O
CDS009561 1,2,5-oxadiazole-3-carboxylic acid AldrichCPR C3H2N2O3
CBR00421 1,2,4-Oxadiazole-3-carbothioamide AldrichCPR C3H3N3OS
CBR00048 5-Methyl-1,2,4-oxadiazol-3-amine AldrichCPR C3H5N3O
CBR00076 4-Methoxy-1,2,5-oxadiazol-3-amine AldrichCPR C3H5N3O2
CDS019857 (1,2,4-Oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C3H6ClN3O
CBR00190 4-(1,2,4-Oxadiazol-3-yl)-1,2,5-oxadiazol-3-amine AldrichCPR C4H3N5O2
CDS019560 5-Methyl-1,2,4-oxadiazole-3-carboxylic acid AldrichCPR C4H4N2O3
CBR00463 3-(Carboxymethyl)-1,2,3-oxadiazol-3-ium-5-olate AldrichCPR C4H4N2O4
CDS019758 5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole AldrichCPR C4H5ClN2O
CBR01637 3-Ethyl-1,2,4-oxadiazol-5-ol AldrichCPR C4H6N2O2
CBR00434 N-(4-Amino-1,2,5-oxadiazol-3-yl)acetamide AldrichCPR C4H6N4O2
CBR01426 3-(Aminomethyl)-1,2,4-oxadiazole-5-carboxamide hydrochloride AldrichCPR C4H7ClN4O2
CDS010118 (3-methyl-1,2,4-oxadiazol-5-yl)methanamine AldrichCPR C4H7N3O
CDS002297 (4-Methyl-1,2,5-oxadiazol-3-yl)methylamine AldrichCPR C4H7N3O
CBR01043 1-(5-Methyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C4H8ClN3O
CBR01604 (3-Methyl-1,2,4-oxadiazol-5-yl)acetonitrile AldrichCPR C5H5N3O
CDS002372 4-(Acetylamino)-1,2,5-oxadiazole-3-carboxylic acid AldrichCPR C5H5N3O4
CDS016583 3-ethyl-1,2,4-oxadiazole-5-carboxylic acid AldrichCPR C5H6N2O3
CBR01097 [(5-Methyl-1,3,4-oxadiazol-2-yl)thio]acetic acid AldrichCPR C5H6N2O3S
CBR00271 5-(Chloromethyl)-3-[(methylthio)methyl]-1,2,4-oxadiazole AldrichCPR C5H7ClN2OS
CBR01639 3-Cyclopropyl-1,2,4-oxadiazol-5-amine AldrichCPR C5H7N3O
CBR00136 5-Cyclopropyl-1,3,4-oxadiazol-2-amine AldrichCPR C5H7N3O
CBR01453 5-Isopropyl-1,3,4-oxadiazol-2-amine AldrichCPR C5H9N3O
CBR01390 5-Propyl-1,3,4-oxadiazol-2-amine AldrichCPR C5H9N3O
CBR01478 N-Methyl-1-(3-methyl-1,2,4-oxadiazol-5-yl)methanamine AldrichCPR C5H9N3O
CBR01380 N-Methyl-1-(5-methyl-1,2,4-oxadiazol-3-yl)methanamine AldrichCPR C5H9N3O
CBR00369 1-[5-(Methoxymethyl)-1,2,4-oxadiazol-3-yl]methanamine AldrichCPR C5H9N3O2
CBR00747 1-(3-Ethyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C5H10ClN3O
CBR01557 1-(5-Ethyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C5H10ClN3O
CBR01684 N-Methyl-2-(1,2,4-oxadiazol-3-yl)ethanamine hydrochloride AldrichCPR C5H10ClN3O
163260 4-Chloro-7-nitrobenzofurazan 98% C6H2ClN3O3
659118 5-Chlorobenzofurazan 97% C6H3ClN2O
391395 5-Chlorobenzofurazan 3-oxide 97% C6H3ClN2O2
CDS016098 2,1,3-benzoxadiazol-5-ol AldrichCPR C6H4N2O2
CBR00147 3-(Chloromethyl)-5-cyclopropyl-1,2,4-oxadiazole AldrichCPR C6H7ClN2O
CBR00059 1-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)methanamine AldrichCPR C6H9N3O
CBR01492 5-Cyclobutyl-1,3,4-oxadiazol-2-amine AldrichCPR C6H9N3O
CBR00843 1-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C6H10ClN3O
CDS020360 5-Azetidin-3-yl-3-methyl-1,2,4-oxadiazole hydrochloride AldrichCPR C6H10ClN3O
CBR00051 (3-Isopropyl-1,2,4-oxadiazol-5-yl)methanol AldrichCPR C6H10N2O2
CBR00256 (5-Isopropyl-1,2,4-oxadiazol-3-yl)methanol AldrichCPR C6H10N2O2
CBR00139 5-tert-Butyl-1,3,4-oxadiazol-2-amine AldrichCPR C6H11N3O
CBR00748 1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C6H12ClN3O
CBR00807 1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C6H12ClN3O
CBR00749 2-(3-Ethyl-1,2,4-oxadiazol-5-yl)ethanamine hydrochloride AldrichCPR C6H12ClN3O
CBR00861 N-Methyl-2-(5-methyl-1,2,4-oxadiazol-3-yl)ethanamine hydrochloride AldrichCPR C6H12ClN3O
CDS016203 2,1,3-benzoxadiazole-5-carbaldehyde AldrichCPR C7H4N2O2
556610 2,1,3-Benzoxadiazole-5-carboxylic acid 97% (GC) C7H4N2O3
CDS014875 4-(bromomethyl)-2,1,3-benzoxadiazole AldrichCPR C7H5BrN2O
680788 5-(3-Pyridyl)-1,3,4-oxadiazole-2-thiol 97% C7H5N3OS
438561 5-(4-Pyridyl)-1,3,4-oxadiazole-2-thiol 97% C7H5N3OS
391409 5-Methoxybenzofurazan 3-oxide 99% C7H6N2O3
CBR01320 5-Cyclopentyl-1,3,4-oxadiazol-2-amine AldrichCPR C7H11N3O
CBR01331 1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)-N-methylmethanamine AldrichCPR C7H13N3O
CBR00589 N-[(3-Ethyl-1,2,4-oxadiazol-5-yl)methyl]ethanamine AldrichCPR C7H13N3O
CBR00841 1-(3-tert-Butyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C7H14ClN3O
CBR00800 N-Methyl-1-(3-propyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C7H14ClN3O
719625 2-(4-Bromophenyl)-1,3,4-oxadiazole 97% C8H5BrN2O
CBR01758 5-Chloro-3-phenyl-1,2,4-oxadiazole AldrichCPR C8H5ClN2O
675032 5-(4-Chlorophenyl)-1,3,4-oxadiazole-2-thiol 97% C8H5ClN2OS
CDS013803 3-(1,3,4-oxadiazol-2-yl)benzenesulfonyl chloride AldrichCPR C8H5ClN2O3S
663425 2-Amino-5-(2-chlorophenyl)-1,3,4-oxadiazole 97% C8H6ClN3O
663387 2-Amino-5-(4-chlorophenyl)-1,3,4-oxadiazole 95% C8H6ClN3O
CBR00508 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]pyridine AldrichCPR C8H6ClN3O
CBR00540 3-[5-(Chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine AldrichCPR C8H6ClN3O
CDS010669 5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylamine AldrichCPR C8H6FN3O
CDS005700 3-(1,3,4-Oxadiazol-2-yl)phenol AldrichCPR C8H6N2O2
663417 2-Amino-5-(4-nitrophenyl)-1,3,4-oxadiazole 97% C8H6N4O3
663395 2-Amino-5-phenyl-1,3,4-oxadiazole 97% C8H7N3O
BOG00033 5-Methyl-3-(2-pyridyl)-1,2,4-oxadiazole 97%, AldrichCPR C8H7N3O
BOG00034 5-Methyl-3-(4-pyridyl)-1,2,4-oxadiazole 97%, AldrichCPR C8H7N3O
CBR01018 (2,1,3-Benzoxadiazol-5-ylmethyl)methylamine hydrochloride AldrichCPR C8H10ClN3O
CDS001323 3-(3-Methyl-1,2,4-oxadiazol-5-yl)piperidine AldrichCPR C8H13N3O
CBR00801 2-(3-Methyl-1,2,4-oxadiazol-5-yl)piperidine hydrochloride AldrichCPR C8H14ClN3O
CBR00862 2-(5-Isopropyl-1,2,4-oxadiazol-3-yl)-N-methylethanamine hydrochloride AldrichCPR C8H16ClN3O
CBR01391 2-(Chloromethyl)-5-phenyl-1,3,4-oxadiazole AldrichCPR C9H7ClN2O
CDS014345 3-(5-methyl-1,3,4-oxadiazol-2-yl)benzenesulfonyl chloride AldrichCPR C9H7ClN2O3S
CDS009803 4-(1H-Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine AldrichCPR C9H7N5O
CDS000772 5-Methyl-3-phenyl-1,2,4-oxadiazole AldrichCPR C9H8N2O
548952 5-(4-Methylphenyl)-1,3,4-oxadiazole-2-thiol C9H8N2OS
548960 5-(4-Methoxyphenyl)-1,3,4-oxadiazole-2-thiol C9H8N2O2S
CDS002248 1-(5-Phenyl-1,3,4-oxadiazol-2-yl)methylamine AldrichCPR C9H9N3O
CBR00157 2-(3-Methyl-1,2,4-oxadiazol-5-yl)aniline AldrichCPR C9H9N3O
CBR00158 4-(3-Methyl-1,2,4-oxadiazol-5-yl)aniline AldrichCPR C9H9N3O
663379 2-Amino-5-(4-methoxyphenyl)-1,3,4-oxadiazole 97% C9H9N3O2
CBR01044 1-(3-Phenyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C9H10ClN3O
CBR00792 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C9H10ClN3O
CDS018136 2-(3-methyl-1,2,4-oxadiazol-5-yl)benzaldehyde AldrichCPR C10H8N2O2
CDS017412 2-(3-methyl-1,2,4-oxadiazol-5-yl)benzoic acid AldrichCPR C10H8N2O3
CDS017215 3-(3-methyl-1,2,4-oxadiazol-5-yl)benzoic acid AldrichCPR C10H8N2O3
CDS009244 3-(5-methyl-1,2,4-oxadiazol-3-yl)benzoic acid AldrichCPR C10H8N2O3
CDS015896 2-[4-(bromomethyl)phenyl]-5-methyl-1,3,4-oxadiazole AldrichCPR C10H9BrN2O
CDS005619 1-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]ethanamine AldrichCPR C10H10ClN3O
CDS017619 2-(3-phenyl-[1,2,4]oxadiazol-5-yl)-ethylamine AldrichCPR C10H11N3O
CBR00353 3-(3-Phenyl-1,2,4-oxadiazol-5-yl)propanoic acid AldrichCPR C11H10N2O3
663409 5-Phenyl-1,3,4-oxadiazole-2-propionic acid 97% C11H10N2O3
CDS017629 [2-(3-methyl-[1,2,4]oxadiazol-5-yl)-phenoxy]-acetic acid AldrichCPR C11H10N2O4
CDS010866 4-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine AldrichCPR C13H14FN3O
CDS014793 4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine AldrichCPR C13H15N3O
553646 2-(4-Bromophenyl)-5-phenyl-1,3,4-oxadiazole 96% C14H9BrN2O
BOG00035 3-(3-Methyl-2-pyridyl)-5-phenyl-1,2,4-oxadiazole 97%, AldrichCPR C14H11N3O
BOG00038 3-(2-Methylphenyl)-5-phenyl-1,2,4-oxadiazole 97%, AldrichCPR C15H12N2O
BOG00037 3-(3-Methylphenyl)-5-phenyl-1,2,4-oxadiazole 97%, AldrichCPR C15H12N2O
BOG00036 3-(4-Methylphenyl)-5-phenyl-1,2,4-oxadiazole 97%, AldrichCPR C15H12N2O
698202 2,5-Bis(1-naphthyl)-1,3,4-oxadiazole 99% C22H14N2O