The piperidone pharmacophore, a nitrogen containing heterocycle, is a privileged structure, widely found in natural products, and displaying a broad-spectrum of biological actions. Piperidone derivatives possess a greater affinity towards cellular thiols than towards amino and hydroxyl groups; thus compounds of this nature may be devoid of the genotoxic side effects associated with many alkylating agents. As α,β-unsaturated ketones, these compounds are capable of undergoing Michael addition, resulting in alkylation of cellular nucleophiles. Piperidones exhibit anticancer, anti-inflammatory, and antimicrobial activity, and also inhibit the NF-κB signaling pathway. 2-Piperidone and 4-piperidone are important intermediates in alkaloid synthesis and in the preparation of medicinal agents. Mannich–Michael, and aza-Diels–Alder reactions involving an imino dienophile and a conjugated diene and enones have been applied to the synthesis of piperidine derivatives.

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Hayashi Catalysts

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Molecular Formula

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759368 2,4-Piperidinedione 97% C5H7NO2
151769 4-Piperidone monohydrate hydrochloride 98% C5H9NO · HCl · H2O
CDS010026 (S)-5-hydroxy-piperidin-2-one AldrichCPR C5H9NO2
CDS006090 3-piperidone hydrochloride AldrichCPR C5H10ClNO
CDS019710 (S)-3-Aminopiperidine-2-one AldrichCPR C5H10N2O
CDS020148 3-Aminopiperidin-2-one AldrichCPR C5H10N2O
757993 (S)-3-Amino-2-piperidone hydrochloride 95% C5H11ClN2O
CDS013956 (S)-5-Amino-piperidin-2-one hydrochloride AldrichCPR C5H11ClN2O
CBR01526 3-Amino-2-piperidinone hydrochloride AldrichCPR C5H11ClN2O
80800 4-Piperidone hydrate hydrochloride purum, ≥98.0% (AT) C5H11NO2 · HCl
529001 4-Hydroxy-6-methyl-3-nitro-2-pyridone 98% C6H6N2O4
CBR01770 2-Oxo-3-piperidinecarboxylic acid AldrichCPR C6H9NO3
CDS003761 6-oxo-pipecolinic acid AldrichCPR C6H9NO3
M73788 N-Methyl-2-piperidone 99% C6H11NO
130036 N-Methyl-4-piperidone 97% C6H11NO
379409 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 98% C7H9NO2
CDS001859 2-(2,6-Dioxo-1-piperidinyl)ethanesulfonyl chloride AldrichCPR C7H10ClNO4S
388254 1-Acetyl-4-piperidone 94% C7H11NO2
130486 1-Ethyl-3-piperidone hydrochloride 97% C7H13NO · HCl
279501 1-Ethyl-4-piperidone 98% C7H13NO
178365 1,4-Dioxa-8-azaspiro[4.5]decane 98% C7H13NO2
CBR01632 1-(Dimethylamino)-4-piperidinone AldrichCPR C7H14N2O
CDS014282 1-allyltetrahydro-4(1h)-pyridinone AldrichCPR C8H13NO
CBR00128 1-Ethyl-6-oxopiperidine-3-carboxylic acid AldrichCPR C8H13NO3
C5505 Ethyl 2-oxo-3-piperidinecarboxylate 99% C8H13NO3
153737 Ethyl 4-oxo-1-piperidinecarboxylate 98% C8H13NO3
555800 1-Oxa-4-azaspiro[4.5]decane 97% C8H15NO
CBR00581 4-(2-Oxopiperidin-1-yl)butanoic acid AldrichCPR C9H15NO3
CBR00270 1-(2-Methoxyethyl)-6-oxopiperidine-3-carboxylic acid AldrichCPR C9H15NO4
553190 1-(2-Methylpropyl)-4-piperidone 97% C9H17NO
713406 1-tert-Butyl-4-piperidone 97% C9H17NO
459119 2,2,6,6-Tetramethyl-4-piperidone 95% C9H17NO
115762 2,2,6,6-Tetramethyl-4-piperidone hydrochloride 98% C9H17NO · HCl
655775 1-(2-Hydroxyethyl)-4-piperidone ethylene ketal 97% C9H17NO3
CBR00537 1-(2-Furylmethyl)piperidin-4-one AldrichCPR C10H13NO2
650811 1-Boc-3-piperidone 97% C10H17NO3
461350 1-Boc-4-piperidone 98% C10H17NO3
688207 1-N-Boc-2-piperidone 97% C10H17NO3
536903 1,2,2,6,6-Pentamethyl-4-piperidone 97% C10H19NO
00833 N-Boc-hexahydro-1H-azepin-4-one ≥95.0% (HPLC) C11H19NO3
CDS007289 1-(4-fluoro-benzoyl)-piperidin-4-one AldrichCPR C12H12FNO2
CBR00485 1-(2-Methylphenyl)piperidin-4-one AldrichCPR C12H15NO
496898 1-Benzyl-2-piperidone ≥98% C12H15NO
153117 1-Benzyl-3-piperidone hydrochloride hydrate 95% C12H15NO · HCl · xH2O
B29806 1-Benzyl-4-piperidone 99% C12H15NO
737534 1-Z-2-Piperidone 95% C13H15NO3
464643 1-Z-4-Piperidone 99% C13H15NO3
131385 1-Phenethyl-4-piperidone 98% C13H17NO
227005 Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% C14H17NO3 · HCl
143200 Ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate hydrochloride technical grade C15H19NO3 · HCl
495972 Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride technical grade C15H19NO3 · HCl
47555 1-Fmoc-4-piperidone ≥98.0% (HPLC) C20H19NO3
706639 N-Fmoc-3-piperidinone 97% C20H19NO3
735582 (R)-1-Fmoc-4-oxopiperidine-2-carboxylic acid C21H19NO5