Pyridazines

Pyridazine, sometimes called 1,2-diazine, is a six-membered ring containing two adjacent nitrogen atoms. Pyridazine is a privileged structure in medicinal chemistry and can be used as an isosteric replacement of phenyl or heteroaromatic rings. Pyridazines can improve the physiochemical properties of drug molecules by increasing their water solubility, participating as hydrogen bond acceptors, and have a high capacity to complex with targets due to their dipole moment. Pyridazine confers bioavailability, especially to the CNS, and can reduce toxicity. Pyridazine is a part of several drug molecules, and the pyradzine pharmacophore has led to a variety of pharmacologically active compounds.

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738255 3,6-Dibromopyridazine 97% C4H2Br2N2
D73200 3,6-Dichloropyridazine 97% C4H2Cl2N2
303097 4,5-Dichloro-3-hydroxypyridazine 98% C4H2Cl2N2O
708364 3,6-Diiodopyridazine 97% C4H2I2N2
CDS020016 3-Amino-4-bromo-6-chloropyridazine AldrichCPR C4H3BrClN3
CDS006451 3-Chloropyridazine AldrichCPR C4H3ClN2
CDS012033 6-chloropyridazine-3-thiol AldrichCPR C4H3ClN2S
759430 3-Amino-6-chloropyridazine 97% C4H4ClN3
P57204 Pyridazine 98% C4H4N2
82685 3(2H)-Pyridazinone ≥97.0% (GC) C4H4N2O
687642 Pyridazine N-oxide 97% C4H4N2O
D119806 Maleic hydrazide ReagentPlus®, 99% C4H4N2O2
725048 3-Aminopyridazine 97% C4H5N3
CDS006078 4-Aminopyridazine AldrichCPR C4H5N3
777633 4-Aminopyridazine 97% C4H5N3
CDS005216 3-aminopyridazine hydrochloride AldrichCPR C4H6ClN3
741272 3,6-Dichloro-4-(trifluoromethyl)pyridazine 95% C5HCl2F3N2
297755 3,6-Dichloropyridazine-4-carboxylic acid 98% C5H2Cl2N2O2
741280 3-(Trifluoromethyl)pyridazine 97% C5H3F3N2
753718 Pyridazine-3-carbonitrile 97% C5H3N3
297747 3,6-Dichloro-4-methylpyridazine 97% C5H4Cl2N2
597716 4,5-Dichloro-2-methyl-3(2H)-pyridazinone 97% C5H4Cl2N2O
297763 4-Pyridazinecarboxylic acid 97% C5H4N2O2
755257 Pyridazine-3-carboxylic acid 97% C5H4N2O2
CDS006407 3-Chloro-5-methylpyridazine AldrichCPR C5H5ClN2
637637 3-Chloro-6-methylpyridazine 97% C5H5ClN2
108596 3-Chloro-6-methoxypyridazine 95% C5H5ClN2O
CDS006584 3-Amino-4-pyridazinecarboxylic acid AldrichCPR C5H5N3O2
107239 3-Methylpyridazine 99% C5H6N2
297771 4-Methylpyridazine 97% C5H6N2
CDS015970 3-hydroxymethylpyridazine AldrichCPR C5H6N2O
668141 3,6-Dihydroxy-4-methylpyridazine 97% C5H6N2O2
CDS015149 6-oxo-1,6-dihydropyridazine-3-carboxylic acid monohydrate AldrichCPR C5H6N2O4
CDS005355 3-amino-6-methylpyridazine AldrichCPR C5H7N3
CDS019129 3-Aminomethylpyridazine AldrichCPR C5H7N3
CDS019328 4-Pyridazinemethanamine AldrichCPR C5H7N3
CDS007894 3-amino-6-methoxypyridazine AldrichCPR C5H7N3O
CDS013306 6-chloro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine AldrichCPR C6H2ClF3N4
ANV00010 3-Bromo-6-chloroimidazo[1,2-b]pyridazine AldrichCPR C6H3BrClN3
CDS006141 3-chloro-6-methylpyridazine-4-carboxylic acid AldrichCPR C6H5ClN2O2
730203 Methyl pyridazine-4-carboxylate 97% C6H6N2O2
CBR01301 (3,6-Dioxo-1,2,3,6-tetrahydropyridazin-4-yl)acetic acid AldrichCPR C6H6N2O4
CBR01607 6-Hydrazinoimidazo[1,2-b]pyridazine AldrichCPR C6H7N5
CDS005955 2-[(6-chloropyridazin-3-yl)amino]ethanol AldrichCPR C6H8ClN3O
CDS003940 3-Chloro-6-(4-iodo-1H-pyrazol-1-yl)pyridazine AldrichCPR C7H4ClIN4
CDS006021 3-Chloro-6-(1H-imidazol-1-yl)pyridazine AldrichCPR C7H5ClN4
CDS005778 3-Chloro-6-(1H-pyrazol-1-yl)pyridazine AldrichCPR C7H5ClN4
CDS002504 3,6-Dimethoxy-4-pyridazinecarboxylic acid AldrichCPR C7H8N2O4
CBR01162 3-(6-Oxo-1,4,5,6-tetrahydropyridazin-3-yl)propanoic acid AldrichCPR C7H10N2O3
126020 1,4-Dichlorophthalazine 95% C8H4Cl2N2
P38706 Phthalazine 98% C8H6N2
P39001 Phthalazone 99% C8H6N2O
CDS008277 3-chloro-5-(1-pyrrolidinyl)pyridazine AldrichCPR C8H10ClN3
CDS004477 4-(6-chloro-pyridazin-3-yl)-morpholine AldrichCPR C8H10ClN3O
CDS020339 1-(6-Pyridazinyl)piperazine AldrichCPR C8H12N4
C82159 Cinnoline-4-carboxylic acid 97% C9H6N2O2
CDS014944 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine AldrichCPR C9H9ClN4
CDS017723 (6-imidazol-1-yl-pyridazin-3-ylamino)-acetic acid AldrichCPR C9H9N5O2
CDS004245 1-(6-chloropyridazin-3-yl)piperidin-4-ol AldrichCPR C9H12ClN3O
176842 1-Phenyl-4,5-dichloro-6-pyridazone ≥99% C10H6Cl2N2O
342319 3-Chloro-6-phenylpyridazine 98% C10H7ClN2
510602 6-Phenyl-3(2H)-pyridazinone 98% C10H8N2O
653578 6-(2-Hydroxyphenyl)-pyridazin-3(2H)-one 97% C10H8N2O2
546305 6-(4-Bromophenyl)-4,5-dihydro-2H-pyridazin-3-one 97% C10H9BrN2O
CBR01164 3-(4-Chlorophenyl)-6-hydrazinopyridazine AldrichCPR C10H9ClN4
CDS004190 3-amino-6-phenylpyridazine AldrichCPR C10H9N3
CBR00023 3-Hydrazino-6-phenylpyridazine AldrichCPR C10H10N4
CDS014822 1-(6-chloro-3-pyridazinyl)-4-piperidinecarboxylic acid AldrichCPR C10H12ClN3O2
CDS011857 1-(6-chloropyridazin-3-yl)piperidine-3-carboxylic acid AldrichCPR C10H12ClN3O2
CDS001302 1-(6-Chloro-3-pyridazinyl)-4-piperidinecarboxamide AldrichCPR C10H13ClN4O
CDS017144 6-piperidin-1-ylpyridazine-3-carboxylic acid AldrichCPR C10H13N3O2
CDS005644 3-(6-chloropyridazin-3-yl)benzoic acid AldrichCPR C11H7ClN2O2
CDS005432 4-(6-chloropyridazin-3-yl)benzoic acid AldrichCPR C11H7ClN2O2
CDS014116 1-(4-chlorophenyl)-4-oxo-1,4-dihydro-3-pyridazinecarboxylic acid AldrichCPR C11H7ClN2O3
CDS016856 1-(3-chlorophenyl)-4-hydroxy-6-oxo-1,6-dihydro-3-pyridazinecarboxylic acid AldrichCPR C11H7ClN2O4
CDS018245 3-amino-5-phenyl-4-pyridazinecarbonitrile AldrichCPR C11H8N4
CDS017245 3-benzyl-6-chloropyridazine AldrichCPR C11H9ClN2
CDS016860 2-(6-chloropyridazin-3-yl)-2-phenylacetonitrile AldrichCPR C12H8ClN3
CDS014975 3-(6-chloro-3-pyridazinyl)-1H-indole AldrichCPR C12H8ClN3
CDS013035 1-(3-chloro-4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid AldrichCPR C12H11ClN2O3
CDS000789 6-Chloro-α-(3-methylphenyl)-3-pyridazineacetonitrile AldrichCPR C13H10ClN3
534234 4-(4-Bromophenyl)-1(2H)-phthalazinone 97% C14H9BrN2O
525553 4-Phenyl-1-(2H)-phthalazinone 97% C14H10N2O
CDS016086 6-Phenyl-5-piperazino-3(2H)-pyridazinone AldrichCPR C14H16N4O
713287 1,2-Di-Boc-piperidazine ≥98.0% (GC) C14H26N2O4
528080 (4-Methylphenyl)-1-(2H)-phthalazinone 95% C15H12N2O
548839 4-(4-Methoxyphenyl)-1-(2H)-phthalazinone 98% C15H12N2O2
CDS007762 4-(tributylstannyl)pyridazine AldrichCPR C16H30N2Sn
CDS010157 (R)-(+)-4-[2-(diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethyl]-1-phthalazinamine AldrichCPR C38H30N3P
JRD0220 2-(6-Chloropyridazin-3-yl)-2-(4-fluorophenyl)acetonitrile AldrichCPR