Aldehydes (R-CHO) are attractive building blocks due to their ability to easily react with many nucleophiles. Because of their high chemical reactivity, aldehydes are important intermediates for the manufacture of resins, plasticizers, solvents, dyes, and pharmaceuticals. Sigma-Aldrich offers an extensive array of compounds containing the aldehyde functional group for use as building blocks in a variety of synthetic procedures. For example, the asymmetric allylation and crotylation of aldehydes and other carbonyl compounds remains one of the most fundamental reactions for the construction of chiral building blocks. The Stetter reaction (conjugate addition of an aldehyde to an α,β-unsaturated compound) is a superb method for the construction of 1,4-dicarbonyl compounds bearing quaternary stereocenters.

Learn More about Aldehydes
Aziridine Aldehydes as Reagents for Rapid and Chemoselective Synthesis of Complex Molecules
Ketone and Aldehyde α-Oxygenation
Unprotected Amino Aldehydes
Jørgensen’s Organocatalysts
EZ-CrotylMix Reagents
Asymmetric Allylboration Using Ipc2B(allyl)
Chiral Silacycles for Enantioselective Allylation and Crotylation Reactions
Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)
Chiral Phosphoric Acids
N-Heterocyclic Carbene (NHC) Compounds