Benzofurans

Benzofuran (coumarone), a heterocyclic compound consisting of fused benzene and furan rings, has been identified as a privileged structure in medicinal chemistry. Benzofuran derviatives have shown biological activities ranging from antifungal and antimicrobial to antagonists for the H3 receptor and angiotensin II. A diversity of synthetic routes can be applied to the synthesis of benzofurans. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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New Reagents for Selective Metalation, Deprotonation, and Additions

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CDS016824 3-bromo-1-benzofuran AldrichCPR C8H5BrO
761796 5-Bromobenzofuran 97% C8H5BrO
303453 3-Bromo-2-coumaranone 95% C8H5BrO2
647187 5-Bromophthalide 97% C8H5BrO2
CDS003452 5-iodo-2,3-dihydrobenzo[b]furan AldrichCPR C8H7IO
CBR01411 2,3-Dihydro-1-benzofuran-3-amine hydrochloride AldrichCPR C8H10ClNO
CDS015785 5-bromo-1-benzofuran-2-carbaldehyde AldrichCPR C9H5BrO2
CDS014745 1-benzofuran-5-carbonyl chloride AldrichCPR C9H5ClO2
CBR00813 (2-Methyl-1-benzofuran-7-yl)amine hydrochloride AldrichCPR C9H10ClNO
CBR00712 (2-Methyl-2,3-dihydro-1-benzofuran-5-yl)amine hydrobromide AldrichCPR C9H12BrNO
CDS016941 1-(1-benzofuran-5-yl)-2-bromo-1-ethanone AldrichCPR C10H7BrO2
CBR00224 5-Bromo-7-methoxy-1-benzofuran-2-carboxylic acid AldrichCPR C10H7BrO4
CDS010624 5-fluoro-3-methyl-1-benzofuran-2-carboxylic acid AldrichCPR C10H7FO3
CDS017733 1-(5-bromo-7-methoxy-1-benzofuran-2-yl)-1-ethanone AldrichCPR C11H9BrO3
748536 Ethyl 5-chlorobenzofuran-3-carboxylate 95% C11H9ClO3
768472 4-Bromodibenzofuran 97% C12H7BrO