Furans

Furans, consisting of a five-membered aromatic ring with one oxygen atom, are an important class of heterocyclic compounds that possess important biological properties. Considerable attention has been focused on the synthesis of furan derivatives and screening them for pharmacological activity. The furan ring system is the basic skeleton of numerous compounds possessing cardiovascular activities. An iodinated lipophilic furan derivative is widely used in the treatment of ventricular and arterial fibrillation. These moieties are widely found in antibacterial, antiviral, anti-inflammatory, antifungal, antitumor, antihyperglycemic analgesic, anticonvulsant, and other agents. Slight changes in substitution patterns in the furan nucleus cause distinguishable differences in their biological activities. Furan derivatives have been found to be inhibitors of biofilm formation for several bacterial species, as well as possess quorum-sensing inhibitory activities. In addition to being synthetic building blocks, 2-methylfuran and 2,5-dimethylfuran are promising lignocellulosic biofuels. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Synthesis of Furans
BOX
Ring-Closing Metathesis

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Molecular Formula

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CDS000239 2,5-Dibromofuran AldrichCPR C4H2Br2O
719226 3,4-Dibromo-2(5H)-furanone 97% C4H2Br2O2
719242 3,4-Dichloro-2(5H)-furanone 97% C4H2Cl2O2
176524 3-Bromofuran 97% C4H3BrO
CBR01676 cis-4-Aminotetrahydro-3-furanol hydrochloride AldrichCPR C4H10ClNO2
656291 4,5-Dibromo-2-furoic acid 97% C5H2Br2O3
CDS004540 3-bromo-2-formylfuran AldrichCPR C5H3BrO2
666599 4-Bromo-2-furaldehyde 97% C5H3BrO2
433985 5-Bromo-2-furaldehyde 97% C5H3BrO2
777730 2-Bromofuran-3-carboxylic acid 96% C5H3BrO3
B67406 5-Bromo-2-furoic acid 99% C5H3BrO3
531456 5-Chloro-2-furaldehyde 98% C5H3ClO2
CDS012743 5-chloro-2-furoic acid AldrichCPR C5H3ClO3
677329 2-(Bromomethyl)-5-nitrofuran 97% C5H4BrNO3
CBR00909 2-Furancarboximidamide hydrochloride AldrichCPR C5H7ClN2O
736767 3-(Bromomethyl)tetrahydrofuran C5H9BrO
CDS001200 Tetrahydrofurfuryl bromide AldrichCPR C5H9BrO
722715 3-(Aminomethyl)tetrahydrofuran hydrochloride 95% C5H12ClNO
CBR00924 trans-4-(Methylamino)tetrahydro-3-furanol hydrochloride AldrichCPR C5H12ClNO2
CDS014856 5-(trifluoromethyl)-2-furaldehyde AldrichCPR C6H3F3O2
CDS014015 2-(bromomethyl)-5-(trifluoromethyl)furan AldrichCPR C6H4BrF3O
CFSS0001 2-(2,2-dibromovinyl)furan AldrichCPR C6H4Br2O
CDS017060 [5-(trifluoromethyl)-2-furyl]methylamine AldrichCPR C6H6F3NO
CDS013888 5-methyl-2-(trifluoromethyl)furan-3-carbonyl chloride AldrichCPR C7H4ClF3O2
CBR00092 5-(5-Isoxazolyl)-2-furansulfonyl chloride AldrichCPR C7H4ClNO4S
541567 Methyl 5-(chloromethyl)-2-furoate 97% C7H7ClO3
CDS015219 methyl 5-(chlorosulfonyl)-2-methyl-3-furoate AldrichCPR C7H7ClO5S
CBR00135 5-(5-Isoxazolyl)-2-methyl-3-furansulfonyl chloride AldrichCPR C8H6ClNO4S
CBR00907 1-[5-(2-Furyl)-3-isoxazolyl]methanamine hydrochloride AldrichCPR C8H9ClN2O2
433993 Ethyl 5-(chloromethyl)-2-furancarboxylate 95% C8H9ClO3
CBR01366 2-Methyl-5-[5-(trifluoroMethyl)-3-isoxazolyl]-3-furansulfonyl chloride AldrichCPR C9H5ClF3NO4S
CBR01488 5-(3,4-Dimethyl-5-isoxazolyl)-2-furansulfonyl chloride AldrichCPR C9H8ClNO4S
CDS005767 1-(5-Bromo-2-furoyl)pyrrolidine AldrichCPR C9H10BrNO2
CBR01722 trans-4-(1-Piperidinyl)tetrahydro-3-furanamine dihydrochloride AldrichCPR C9H20Cl2N2O
CBR01564 trans-4-(4-Methyl-1-piperazinyl)tetrahydro-3-furanamine trihydrochloride AldrichCPR C9H22Cl3N3O
CDS020399 3-(4-Fluorophenyl)dihydrofuran-2,5-dione AldrichCPR C10H7FO3
CBR00753 3-(2-Furyl)aniline hydrochloride AldrichCPR C10H10ClNO
CBR00754 4-(2-Furyl)aniline hydrochloride AldrichCPR C10H10ClNO
588903 5-(4-Chlorophenyl)-2-furonitrile 97% C11H6ClNO
567973 5-(4-Chloro-2-nitrophenyl)furfural 97% C11H6ClNO4
567981 5-(2,4-Dichlorophenyl)furfural 97% C11H6Cl2O2
568309 5-(2,5-Dichlorophenyl)furfural 96% C11H6Cl2O2
574112 5-(3,4-Dichlorophenyl)furfural 97% C11H6Cl2O2
574139 5-(2,4-Dichlorophenyl)-2-furoic acid 96% C11H6Cl2O3
588911 5-(2,5-Dichlorophenyl)-2-furoic acid 97% C11H6Cl2O3
592773 5-(3,4-Dichlorophenyl)-2-furoic acid 97% C11H6Cl2O3
436925 5-(4-Bromophenyl)furfural 97% C11H7BrO2
568295 5-(4-Bromophenyl)-2-furoic acid 98% C11H7BrO3
428477 5-(2-Chlorophenyl)furfural 95% C11H7ClO2
428485 5-(3-Chlorophenyl)furfural 95% C11H7ClO2
428493 5-(4-Chlorophenyl)furfural 95% C11H7ClO2
428531 5-(4-Chlorophenyl)-2-furoic acid 97% C11H7ClO3
CDS006517 5-(2-fluoro-phenyl)-furan-2-carbaldehyde AldrichCPR C11H7FO2
CBR00765 1-(2-Furyl)-1-phenylmethanamine hydrochloride AldrichCPR C11H12ClNO
CBR01109 1-(2-Furylmethyl)piperidine-3-carboxylic acid hydrochloride AldrichCPR C11H16ClNO3
447765 5-[2-Chloro-5-(trifluoromethyl)phenyl]furfural 97% C12H6ClF3O2
447846 5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-furoic acid 96% C12H6ClF3O3
CDS001868 5-(4-Chlorophenyl)-2-(trifluoromethyl)furan-3-carboxylic acid AldrichCPR C12H6ClF3O3
CDS010190 4-chloro-3-(5-formyl-furan-2-yl)-benzoic acid AldrichCPR C12H7ClO4
CBR01461 5-(2-Bromo-4-methylphenyl)-2-furaldehyde AldrichCPR C12H9BrO2
574120 5-(3-Chloro-4-methoxyphenyl)furfural 97% C12H9ClO3
CBR01190 3-(4-Fluorophenyl)-3-(2-furyl)propan-1-amine AldrichCPR C13H14FNO
631213 3-[5-(4-Chlorophenyl)furan-2-yl]acrylic acid 97% C13H9CIO3