Indoles

The indole subunit is a near-ubiquitous component of biologically active natural products, and its study has been a major focus of research for generations. Substituted indoles have frequently been referred to as privileged structures since they are capable of binding to multiple receptors with high affinity, and thus have applications across a wide range of therapeutic areas. Due to this activity, it is not surprising that the indole ring system has become an important building block or intermediate in the synthesis of many pharmaceutical agents. Notably, indole-3-carbinol, found in cruciferous vegetables, inhibits carcinogenesis at the initiation stage and has been shown to inhibit carcinogenesis in several animal species; but, it enhances tumor incidence if administered at a post-initiation stage. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Indoles and Indole Isosteres

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702315 5-Bromo-3-chloro-7-azaindole 96% C7H4BrClN2
702307 5-Bromo-3-iodo-7-azaindole 97% C7H4BrIN2
694711 3-Bromo-7-azaindole 97% C7H5BrN2
703451 4-Bromo-7-azaindole 96% C7H5BrN2
692549 5-Bromo-7-azaindole 97% C7H5BrN2
732168 7-Bromo-6-azaindole 95% C7H5BrN2
692557 3-Chloro-7-azaindole 97% C7H5ClN2
696218 4-Chloro-7-azaindole 97% C7H5ClN2
692298 3-Iodo-7-azaindole 95% C7H5IN2
750379 5,7-Dibromoisatin 97% C8H3Br2NO2
597813 4,7-Dichloroisatin 97% C8H3Cl2NO2
633623 5,7-Dichloroisatin ≥95% C8H3Cl2NO2
476994 5-Bromoisatin technical grade, 90% C8H4BrNO2
CDS000133 6-Bromo-1H-indole-2,3-dione AldrichCPR C8H4BrNO2
679127 7-Bromoisatin 96% C8H4BrNO2
140562 5-Chloroisatin 97% C8H4ClNO2
CDS000344 6-Chloro-1H-indole-2,3-dione AldrichCPR C8H4ClNO2
675040 7-Chloroisatin 97% C8H4ClNO2
679119 7-Fluoroisatin 96% C8H4FNO2
140589 5-Iodoisatin technical grade C8H4INO2
691526 6-Bromo-5-fluoroindole 97% C8H5BrFN
701009 5-Bromo-7-iodoindole 97% C8H5BrIN
CDS001673 7-Bromo-5-nitro-1H-indole AldrichCPR C8H5BrN2O2
708798 5,7-Dibromoindole 97% C8H5Br2N
707120 5-Chloro-7-iodoindole 96% C8H5ClIN
CDS012113 6-chloro-2-oxoindoline-5-sulfonyl chloride AldrichCPR C8H5Cl2NO3S
707058 7-Fluoro-5-iodoindole 97% C8H5FIN
524336 4-Bromoindole 96% C8H6BrN
B68607 5-Bromoindole 99% C8H6BrN
524344 6-Bromoindole 96% C8H6BrN
473723 7-Bromoindole 96% C8H6BrN
586552 5-Bromo-2-oxindole 97% C8H6BrNO
CDS009180 5-bromoisoindolin-1-one AldrichCPR C8H6BrNO
586595 6-Bromo-2-oxindole 97% C8H6BrNO
246220 4-Chloroindole 98% C8H6ClN
C47604 5-Chloroindole 98% C8H6ClN
246239 6-Chloroindole 99% C8H6ClN
473731 7-Chloroindole 97% C8H6ClN
127485 5-Chloro-2-oxindole 98% C8H6ClNO
636215 6-Chloro-2-oxindole 97% C8H6ClNO
691712 7-Chloro-2-oxindole 97% C8H6ClNO
740764 7-Fluoro-1H-indole 97% C8H6FN
563838 5-Iodoindole 97% C8H6IN
687766 7-Iodoindole 97% C8H6IN
CDS015232 7-amino-5-bromoindole AldrichCPR C8H7BrN2
760803 2-Chloro-3-methyl-7-azaindole 97% C8H7ClN2
CBR01431 3-Amino-7-chloro-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C8H8Cl2N2O
CBR00797 3-Amino-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C8H9ClN2O
737054 5-Aminooxindole hydrochloride C8H9ClN2O
CDS013933 4,5,6,7-tetrafluoroindole-3-carboxaldehyde AldrichCPR C9H3F4NO
754684 5,7-Dibromoindole-3-carboxaldehyde 97% C9H5Br2NO
766348 5-Chloro-7-iodoindole-3-carboxaldehyde 97% C9H5ClINO
CDS007903 5,7-Dichloro-1H-indole-2-carboxylic acid AldrichCPR C9H5Cl2NO2
755400 7-Fluoro-5-iodoindole-3-carboxaldehyde 97% C9H5FINO
518743 5-Bromoindole-3-carboxaldehyde 98% C9H6BrNO
666416 6-Bromoindole-3-carboxaldehyde 97% C9H6BrNO
754625 7-Bromoindole-3-carboxaldehyde 96% C9H6BrNO
B2761 5-Bromoindole-2-carboxylic acid 98% C9H6BrNO2
CDS006283 6-bromoindole-2-carboxylic acid AldrichCPR C9H6BrNO2
533076 5-Chloroindole-3-carboxaldehyde 98% C9H6ClNO
C47809 5-Chloroindole-2-carboxylic acid 98% C9H6ClNO2
CDS002296 7-Chloro-1H-indole-2-carboxylic acid AldrichCPR C9H6ClNO2
CDS005445 7-Chloro-1H-indole-3-carboxylic acid AldrichCPR C9H6ClNO2
701068 5-(Trifluoromethyl)indole 97% C9H6F3N
CDS001039 6-(Trifluoromethyl)indole AldrichCPR C9H6F3N
CDS008597 5-(trifluoromethyl)oxindole AldrichCPR C9H6F3NO
755370 7-Iodoindole-3-carboxaldehyde 97% C9H6INO
720860 4-Bromo-1-methylindole 95% C9H8BrN
718300 5-Bromo-1-methylindole 97% C9H8BrN
511528 5-Bromo-2-methylindole 98% C9H8BrN
752355 5-Bromo-3-methylindole 97% C9H8BrN
707155 6-Bromo-7-methylindole 97% C9H8BrN
524867 7-Bromo-2-methylindole C9H8BrN
709654 7-Bromo-5-methylindole 96% C9H8BrN
736724 5-Bromo-2-(hydroxymethyl)indole 95% C9H8BrNO
CDS019787 1-Methyl-1H-indole-5-sulfonyl chloride AldrichCPR C9H8ClNO2S
707147 6-Fluoro-7-methylindole 97% C9H8FN
CDS009038 4-fluoro-5-hydroxy-2-methylindole AldrichCPR C9H8FNO
CDS007332 4-Cyano-isoindoline hydrochloride AldrichCPR C9H9ClN2
737070 2-(Aminomethyl)-5-fluoroindole 95% C9H9FN2
CDS001618 7-(Trifluoromethyl)-1H-indole-2-carboxylic acid AldrichCPR C10H6F3NO2
CDS001670 5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid AldrichCPR C10H6F3NO3
759244 5-Bromo-7-methylindole-3-carboxaldehyde 97% C10H8BrNO
762520 6-Bromo-7-methylindole-3-carboxaldehyde 97% C10H8BrNO
776904 7-Acetyl-5-bromoindole 96% C10H8BrNO
754692 7-Bromo-5-methylindole-3-carboxaldehyde 97% C10H8BrNO
374210 5-Bromoindoxyl acetate 98% C10H8BrNO2
CBR01647 6-Chloro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
CDS001923 5-Fluoro-3-methyl-1H-indole-2-carbaldehyde AldrichCPR C10H8FNO
CDS008881 6-fluoroindole-3-acetic acid AldrichCPR C10H8FNO2
CDS002096 5-Fluoro-7-(methylsulfonyl)-1H-indole-2-carboxylic acid AldrichCPR C10H8FNO4S
A6250 1-Acetyl-5-bromo-7-nitroindoline ≥98% C10H9BrN2O3
376523 3-(2-Bromoethyl)indole 97% C10H10BrN
A6125 1-Acetyl-5-bromoindoline ≥99% C10H10BrNO
CDS008022 5-fluorotryptamine AldrichCPR C10H11FN2
CDS000212 2-(5-Chloro-1H-indol-3-yl)ethylamine hydrochloride AldrichCPR C10H12Cl2N2
CBR01432 3-Amino-5-ethyl-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C10H13ClN2O
CBR01137 2-(2,3-Dihydro-1H-indol-1-yl)ethanamine dihydrochloride AldrichCPR C10H16Cl2N2
724718 Ethyl 5-bromoindole-2-carboxylate 95% C11H10BrNO2
138096 Ethyl 5-chloro-2-indolecarboxylate 97% C11H10ClNO2
B82707 5-Bromo-DL-tryptophan 99% C11H11BrN2O2
CDS018902 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine AldrichCPR C11H12Cl2N2
B5877 5-Bromogramine C11H13BrN2
CDS009009 2-(5-Chloro-1-methyl-1H-indol-3-yl)-ethylamine AldrichCPR C11H13ClN2
CDS002593 [(6-Fluoro-7-methyl-1H-indol-2-l)methyl]-methylamine AldrichCPR C11H13FN2
CBR00758 3-(1,3-Dihydro-2H-isoindol-2-yl)propanoic acid hydrochloride AldrichCPR C11H14ClNO2
CBR01048 6-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride hydrate AldrichCPR C11H14Cl2N2O
CBR01262 N-Methyl-1-(3-methyl-1H-indol-2-yl)methanamine hydrochloride AldrichCPR C11H15ClN2
139076 5-Bromo-4-chloroindoxyl 1,3-diacetate 98% C12H9BrClNO3
CDS002406 5-Chloro-1-(2-methoxyethyl)-1H-indole-2-carboxylic acid AldrichCPR C12H12ClNO3
CBR00759 4-(1,3-Dihydro-2H-isoindol-2-yl)butanoic acid hydrochloride AldrichCPR C12H16ClNO2
CDS006850 4-(1-Piperazinyl)-1H-indole dihydrochloride AldrichCPR C12H17Cl2N3
557749 N-Boc-5-bromoindole 97% C13H14BrNO2
636754 1-(tert-Butoxycarbonyl)-5-chloroindole 97% C13H14ClNO2
CDS003362 1-(2,6-dichlorophenyl)-2-indolinone AldrichCPR C14H9Cl2NO
CDS013552 2-(4-chlorophenyl)indole AldrichCPR C14H10ClN
740101 N-Boc-2-bromo-3-methylindole 97% C14H16BrNO2
CBR01560 tert-Butyl 5-(aminomethyl)-1H-indole-1-carboxylate hydrochloride AldrichCPR C14H19ClN2O2
CBR01249 5-Chloro-3-phenyl-1H-indole-2-carboxylic acid AldrichCPR C15H10ClNO2