Isoxazoles

Isoxazole (azole) derivatives are found in some natural products, such as ibotenic acid, as well as a number of drugs, including a COX-2 inhibitor, and furoxan, a nitric oxide donor. Isoxazoles are useful isosteres of pyridine, and have been found to inhibit voltage-gated sodium channels to control pain, enable the construction of tetracycline antibiotic derivatives, and as treatments for depression. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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724637 4-Bromoisoxazole 95% C3H2BrNO
CBR01544 4-Isoxazolidinol hydrochloride hydrochloride AldrichCPR C3H8ClNO2
CDS020273 4-(Bromomethyl)isoxazole AldrichCPR C4H4BrNO
CDS015521 4-iodo-5-methyl-isoxazole AldrichCPR C4H4INO
722324 5-Amino-4-bromo-3-methylisoxazole 97% C4H5BrN2O
CDS019198 c-Isoxazol-3-yl-methylamine hydrochloride AldrichCPR C4H7ClN2O
CDS005019 5-Methyl-4-isoxazolecarbonyl chloride AldrichCPR C5H4ClNO2
644765 5-(Chloromethyl)isoxazole-4-carboxylic acid 97% C5H4ClNO3
CDS014402 3-(bromomethyl)-5-methylisoxazole AldrichCPR C5H6BrNO
544299 4-Bromo-3,5-dimethylisoxazole 95% C5H6BrNO
CDS020279 5-(Bromomethyl)-3-methylisoxazole AldrichCPR C5H6BrNO
CDS005176 3-chloromethyl-5-methylisoxazole AldrichCPR C5H6ClNO
CDS015081 4-iodo-3,5-dimethylisoxazole AldrichCPR C5H6INO
CBR01808 Methyl 4-bromo-5-methyl-3-isoxazolecarboxylate AldrichCPR C6H6BrNO3
CBR00339 3-(3-Chloroisoxazol-5-yl)propanoic acid AldrichCPR C6H6ClNO3
CDS019604 4-(Bromomethyl)-3,5-dimethylisoxazole AldrichCPR C6H8BrNO
247316 4-Chloromethyl-3,5-dimethylisoxazole 98% C6H8ClNO
CBR01314 5-(Bromomethyl)-3-ethyl-4,5-dihydroisoxazole AldrichCPR C6H10BrNO
CBR01039 1-(3,5-Dimethylisoxazol-4-yl)methanamine hydrochloride AldrichCPR C6H11ClN2O
CBR00808 3-Isoxazolidin-2-ylpropanoic acid hydrochloride AldrichCPR C6H12ClNO3
CDS014754 2-bromo-5-(isoxazol-5-yl)thiophene AldrichCPR C7H4BrNOS
CDS014217 5-Chloro-1,2-benzisoxazol-3(2H)-one AldrichCPR C7H4ClNO2
CDS017027 6-chlorobenzo[d]isoxazol-3-ol AldrichCPR C7H4ClNO2
CDS019280 1,2-Benzisoxazole-5-sulfonyl chloride AldrichCPR C7H4ClNO3S
CDS008140 6-bromobenzo[d]isoxazol-3-amine AldrichCPR C7H5BrN2O
CBR00283 5-(Chloromethyl)-3-isopropylisoxazole AldrichCPR C7H10ClNO
CBR00905 1-(5-Cyclopropyl-3-isoxazolyl)methanamine hydrochloride AldrichCPR C7H11ClN2O
CBR01346 1-(3,5-Dimethyl-4-isoxazolyl)-N-methylmethanamine hydrochloride AldrichCPR C7H13ClN2O
CBR00794 1-(3-Isopropylisoxazol-5-yl)methanamine hydrochloride AldrichCPR C7H13ClN2O
CBR00832 1-(3-Propylisoxazol-5-yl)methanamine hydrochloride AldrichCPR C7H13ClN2O
CDS014383 5-(2-methyl-1,3-thiazol-4-yl)-3-isoxazolecarbonyl chloride AldrichCPR C8H5ClN2O2S
CDS008319 3-(bromomethyl)-1,2-benzisoxazole AldrichCPR C8H6BrNO
CDS009348 5-bromo-3-methylbenzo[d]isoxazole AldrichCPR C8H6BrNO
CDS003558 6-bromo-3-methylbenzo[d]isoxazole AldrichCPR C8H6BrNO
CDS018128 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-4-isoxazolecarbonyl chloride AldrichCPR C8H6ClN3O2S
CBR00907 1-[5-(2-Furyl)-3-isoxazolyl]methanamine hydrochloride AldrichCPR C8H9ClN2O2
CBR00833 1-(3-Isobutylisoxazol-5-yl)methanamine hydrochloride AldrichCPR C8H15ClN2O
JRD0114 4-Bromo-5-(4-chlorophenyl)isoxazole AldrichCPR C9H5BrClNO
JRD0116 4-Bromo-5-(4-fluorophenyl)isoxazole AldrichCPR C9H5BrFNO
JRD0115 4-Bromo-5-(4-bromophenyl)isoxazole AldrichCPR C9H5Br2NO
CBR01366 2-Methyl-5-[5-(trifluoroMethyl)-3-isoxazolyl]-3-furansulfonyl chloride AldrichCPR C9H5ClF3NO4S
465461 2,4-Dichloro-6-(5-isoxazolyl)phenol 97% C9H5Cl2NO2
CDS015955 5,7-Dichloro-2-(5-methylisoxazol-3-yl)[1,2,4]triazolo[1,5-a]pyrimidine AldrichCPR C9H5Cl2N5O
CDS011015 5-(3,5-difluorophenyl)isoxazole AldrichCPR C9H5F2NO
JRD0111 4-Bromo-5-phenylisoxazole AldrichCPR C9H6BrNO
CDS006023 5-(3-Bromophenyl)isoxazole AldrichCPR C9H6BrNO
CDS020031 5-(4-Bromophenyl)isoxazole AldrichCPR C9H6BrNO
465496 4-Bromo-2-(5-isoxazolyl)phenol 97% C9H6BrNO2
JRD0213 3-(4-Chlorophenyl)isoxazole AldrichCPR C9H6ClNO
465437 4-Chloro-2-(5-isoxazolyl)phenol 97% C9H6ClNO2
JRD0166 3-(4-Fluorophenyl)isoxazole AldrichCPR C9H6FNO
JRD0098 5-(4-Fluorophenyl)isoxazole AldrichCPR C9H6FNO
JRD0163 3-(3-Bromophenyl)isoxazol-5-amine AldrichCPR C9H7BrN2O
676276 3-Amino-5-(4-bromophenyl)isoxazole technical grade C9H7BrN2O
CDS016314 3-(3-chloro-phenyl)-isoxazol-5-ylamine AldrichCPR C9H7ClN2O
CDS010291 4-(4-chloro-phenyl)-isoxazol-5-ylamine AldrichCPR C9H7ClN2O
JRD0171 4-(4-Chlorophenyl)isoxazol-5-amine AldrichCPR C9H7ClN2O
JRD0177 5-(4-Chlorophenyl)isoxazol-3-amine AldrichCPR C9H7ClN2O
644943 5-Amino-3-(4-chlorophenyl)isoxazole 97% C9H7ClN2O
JRD0164 3-(3-Fluorophenyl)isoxazol-5-amine AldrichCPR C9H7FN2O
676268 3-Amino-5-(4-fluorophenyl)isoxazole 97% C9H7FN2O
JRD0172 4-(4-Fluorophenyl)isoxazol-5-amine AldrichCPR C9H7FN2O
CBR00846 3-[5-(Chloromethyl)isoxazol-3-yl]pyridine hydrochloride AldrichCPR C9H8Cl2N2O
CBR00845 4-[5-(Chloromethyl)isoxazol-3-yl]pyridine hydrochloride AldrichCPR C9H8Cl2N2O
CBR00632 1-(3-Pyridin-3-ylisoxazol-5-yl)methanamine dihydrochloride AldrichCPR C9H11Cl2N3O
645001 5-(4-Bromophenyl)isoxazole-3-carboxylic acid 95% C10H6BrNO3
JRD0150 3-(2-Chlorophenyl)isoxazole-5-carbaldehyde AldrichCPR C10H6ClNO2
JRD0155 3-(3-Chlorophenyl)isoxazole-5-carbaldehyde AldrichCPR C10H6ClNO2
645036 5-(4-Chlorophenyl)isoxazole-3-carboxaldehyde 97% C10H6ClNO2
JRD0154 3-(3-Chlorophenyl)isoxazole-5-carboxylic acid AldrichCPR C10H6ClNO3
644994 5-(4-Chlorophenyl)isoxazole-3-carboxylic acid 97% C10H6ClNO3
JRD0151 3-(2-Fluorophenyl)isoxazole-5-carbaldehyde AldrichCPR C10H6FNO2
JRD0156 3-(3-Fluorophenyl)isoxazole-5-carbaldehyde AldrichCPR C10H6FNO2
CDS017487 3-(2-fluoro-phenyl)-isoxazole-5-carboxylic acid AldrichCPR C10H6FNO3
JRD0142 5-(Bromomethyl)-3-(4-chlorophenyl)isoxazole AldrichCPR C10H7BrClNO
JRD0144 5-(Bromomethyl)-3-(4-fluorophenyl)isoxazole AldrichCPR C10H7BrFNO
JRD0143 5-(Bromomethyl)-3-(4-bromophenyl)isoxazole AldrichCPR C10H7Br2NO
CDS013259 [3-(4-fluorophenyl)isoxazol-5-yl]methanesulfonyl chloride AldrichCPR C10H7ClFNO3S
CDS016412 5-(chloromethyl)-3-(4-chlorophenyl)isoxazole AldrichCPR C10H7Cl2NO
JRD0112 4-Bromo-5-p-tolylisoxazole AldrichCPR C10H8BrNO
JRD0140 5-(Bromomethyl)-3-phenylisoxazole AldrichCPR C10H8BrNO
JRD0120 (3-(4-Bromophenyl)isoxazol-5-yl)methanol AldrichCPR C10H8BrNO2
JRD0113 4-Bromo-5-(4-methoxyphenyl)isoxazole AldrichCPR C10H8BrNO2
644625 5-(4-Bromophenyl)isoxazole-3-carboxylic acid hydrazide 97% C10H8BrN3O2
CDS012704 3-(chloromethyl)-5-phenylisoxazole AldrichCPR C10H8ClNO
JRD0148 (3-(2-Chlorophenyl)isoxazol-5-yl)methanol AldrichCPR C10H8ClNO2
JRD0160 (3-(3-Chlorophenyl)isoxazol-5-yl)methanol AldrichCPR C10H8ClNO2
JRD0119 (3-(4-Chlorophenyl)isoxazol-5-yl)methanol AldrichCPR C10H8ClNO2
CDS016477 [3-(2-chloro-phenyl)-isoxazol-5-yl]-methanol AldrichCPR C10H8ClNO2
CDS008755 [3-(4-chlorophenyl)-5-isoxazolyl]methanol AldrichCPR C10H8ClNO2
465488 4-Chloro-2-(5-isoxazolyl)-5-methylphenol 98% C10H8ClNO2
JRD0159 (3-(2-Fluorophenyl)isoxazol-5-yl)methanol AldrichCPR C10H8FNO2
JRD0161 (3-(3-Fluorophenyl)isoxazol-5-yl)methanol AldrichCPR C10H8FNO2
JRD0122 [3-(4-fluoro-phenyl)-isoxazol-5-yl]-methanol AldrichCPR C10H8FNO2
CDS006853 [3-(4-fluoro-phenyl)-isoxazol-5-yl]-methanol AldrichCPR C10H8FNO2
CDS002536 3-(2-Fluorophenyl)-4,5-dihydro-5-isoxazolecarboxylic acid AldrichCPR C10H8FNO3
CDS014329 4-iodo-3-methyl-5-phenylisoxazole AldrichCPR C10H8INO
CDS014470 4-iodo-5-methyl-3-phenylisoxazole AldrichCPR C10H8INO
CDS008754 [3-(4-chlorophenyl)-5-isoxazolyl]methanamine AldrichCPR C10H9ClN2O
CDS005629 4-(4-fluorophenyl)-3-methylisoxazol-5-amine AldrichCPR C10H9FN2O
CDS018070 3-(4-fluorophenyl)-N′-hydroxy-4,5-dihydro-5-isoxazolecarboximidamide AldrichCPR C10H10FN3O2
CBR00633 N-Methyl-1-(3-pyridin-3-ylisoxazol-5-yl)methanamine dihydrochloride AldrichCPR C10H13Cl2N3O
CBR00634 N-Methyl-1-(3-pyridin-4-ylisoxazol-5-yl)methanamine dihydrochloride AldrichCPR C10H13Cl2N3O
CBR01362 5-(Chloromethyl)-3-cyclohexylisoxazole AldrichCPR C10H14ClNO
JRD0126 3-(4-Bromophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylic acid AldrichCPR C11H5BrF3NO3
JRD0125 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylic acid AldrichCPR C11H5ClF3NO3
JRD0127 5-(Trifluoromethyl)-3-(4-fluorophenyl)isoxazole-4-carboxylic acid AldrichCPR C11H5F4NO3
CDS001311 2-Chloro-N-(4-cyano-3-methyl-5-isoxazolyl)nicotinamide AldrichCPR C11H7ClN4O2
CDS014968 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamide AldrichCPR C11H8ClFN2O2
CDS014362 5-methyl-3-phenyl-4-isoxazolecarbonyl chloride AldrichCPR C11H8ClNO2
CDS011928 5-(3-chloro-4-methoxy-phenyl)-isoxazole-3-carboxylic acid AldrichCPR C11H8ClNO4
CDS011929 5-(3-fluoro-4-methoxy-phenyl)-isoxazole-3-carboxylic acid AldrichCPR C11H8FNO4
JRD0103 4-(Bromomethyl)-3-(4-chlorophenyl)-5-methylisoxazole AldrichCPR C11H9BrClNO
JRD0105 4-(Bromomethyl)-3-(4-fluorophenyl)-5-methylisoxazole AldrichCPR C11H9BrFNO
JRD0104 4-(Bromomethyl)-3-(4-bromophenyl)-5-methylisoxazole AldrichCPR C11H9Br2NO
CDS014327 4-(bromomethyl)-3-methyl-5-phenylisoxazole AldrichCPR C11H10BrNO
JRD0101 4-(Bromomethyl)-5-methyl-3-phenylisoxazole AldrichCPR C11H10BrNO
JRD0141 5-(Bromomethyl)-3-p-tolylisoxazole AldrichCPR C11H10BrNO
JRD0132 2-(3-(4-Bromophenyl)isoxazol-5-yl)ethanol AldrichCPR C11H10BrNO2
JRD0145 5-(Bromomethyl)-3-(4-methoxyphenyl)isoxazole AldrichCPR C11H10BrNO2
CDS016852 1-[3-(4-chlorophenyl)-5-isoxazolyl]-1-ethanol AldrichCPR C11H10ClNO2
JRD0131 2-(3-(4-Chlorophenyl)isoxazol-5-yl)ethanol AldrichCPR C11H10ClNO2
JRD0133 2-(3-(4-Fluorophenyl)isoxazol-5-yl)ethanol AldrichCPR C11H10FNO2
CDS004992 3-ethyl-4-(4-fluorophenyl)isoxazol-5-amine AldrichCPR C11H11FN2O
CDS017288 2-[3-(4-fluorophenyl)-4,5-dihydro-5-isoxazolyl]acetamide AldrichCPR C11H11FN2O2
CBR01269 N-Methyl-1-(3-phenylisoxazol-5-yl)methanamine hydrochloride AldrichCPR C11H13ClN2O
657980 5-(4-Bromophenyl)isoxazole-3-propionic acid 97% C12H10BrNO3
JRD0244 Ethyl 5-(4-bromophenyl)isoxazole-3-carboxylate AldrichCPR C12H10BrNO3
CDS015291 1-[3-(4-chlorophenyl)-5-methylisoxazol-4-yl]ethan-1-one AldrichCPR C12H10ClNO2
CDS016506 2-chloro-5-(3,5-dimethyl-isoxazol-4-yl)-benzoic acid AldrichCPR C12H10ClNO3
CDS014704 3-(4-methoxyphenyl)-5-methyl-4-isoxazolecarbonyl chloride AldrichCPR C12H10ClNO3
657972 5-(4-Chlorophenyl)isoxazole-3-propionic acid 97% C12H10ClNO3
JRD0245 Ethyl 5-(4-fluorophenyl)isoxazole-3-carboxylate AldrichCPR C12H10FNO3
CDS009341 3-(4-fluorophenyl)-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine AldrichCPR C12H11FN2O
JRD0102 4-(Bromomethyl)-5-methyl-3-p-tolylisoxazole AldrichCPR C12H12BrNO
JRD0106 4-(Bromomethyl)-3-(4-methoxyphenyl)-5-methylisoxazole AldrichCPR C12H12BrNO2
CDS016786 3-(5-chloro-2,4-dimethoxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid AldrichCPR C12H12ClNO5
758205 6-Fluoro-3-(4-piperidinyl)benzisoxazole 95% C12H13FN2O
642657 5-Chloro-3-phenyl-2,1-benzisoxazole 97% C13H8ClNO
JRD0100 Ethyl 3-(4-fluorophenyl)-5-methylisoxazole-4-carboxylate AldrichCPR C13H12FNO3
CDS019121 3-(3-Aminomethyl-phenyl)-6,7-dihydro-5H-isoxazolo[4,5-c]pyridin-4-one hydrochloride AldrichCPR C13H14ClN3O2
CDS017178 3-(4-chlorophenyl)-2,1-benzisoxazole-5-carbaldehyde AldrichCPR C14H8ClNO2
CDS008865 3-[3-(2-chloro-phenyl)-5-methyl-isoxazol-4-yl]-3-oxo-propionic acid methyl ester AldrichCPR C14H12ClNO4
JRD0288 (3-(2,5-Dichlorophenyl)isoxazol-5-yl)methanol AldrichCPR  
JRD0294 2-Bromo-1-(3-(4-bromophenyl)-5-methylisoxazol-4-yl)ethanone AldrichCPR  
JRD0240 Ethyl 2-(4-bromo-2-(isoxazol-5-yl)phenoxy)acetate AldrichCPR  
JRD0241 Ethyl 2-(4-fluoro-2-(isoxazol-5-yl)phenoxy)acetate AldrichCPR  
JRD0278 Ethyl 3-(4-bromophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylate AldrichCPR  
JRD0243 Ethyl 5-(4-chlorophenyl)isoxazole-3-carboxylate AldrichCPR  
JRD0227 Ethyl 5-amino-4-(4-chlorophenyl)isoxazole-3-carboxylate AldrichCPR  
JRD0247 Methyl 5-(4-fluorophenyl)isoxazole-3-carboxylate AldrichCPR