Morpholines/Thiomorpholines

Morpholines are six-membered heterocycles featuring both amine and ether functional groups. Substituted morpholine derivatives are the core of various natural products and biologically active compounds. This class of compounds has found important applications in pharmaceuticals and agriculture. Chiral morpholine derivatives have found numerous applications in asymmetric synthesis as chiral auxiliaries as well as chiral ligands. Morpholine derivatives from synthesis and natural products have exhibited activity as antidepressants, appetite suppressants, antitumor agents, antioxidants, antibiotics, selective α1-agonists in the treatment of dementia and other central nervous system (CNS) disorders characterized by symptoms of noradrenergic insufficiency, as well as potent long acting human neurokinin-1 (hNK-1) receptor antagonists. Morpholines have several industrial applications, such as corrosion inhibitors, optical bleaching agents, and in textile dying, and fruit preservation. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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730556 N-Iodomorpholine hydriodide 97% C4H9I2NO
CDS019871 1-Oxide thiomorpholine hydrochloride AldrichCPR C4H10ClNOS
CDS001609 Homomorpholine hydrochloride AldrichCPR C5H12ClNO
CDS019178 4-(Bromoacetyl)morpholine AldrichCPR C6H10BrNO2
C42203 4-(2-Chloroethyl)morpholine hydrochloride 99% C6H12ClNO · HCl
23051 4-(2-Chloroethyl)morpholine hydrochloride purum, ≥97.0% (AT) C6H12ClNO · HCl
CDS020100 2-(Hydroxymethyl)homomorpholine hydrochloride AldrichCPR C6H14ClNO2
CBR01836 1-(4-Methyl-2-morpholinyl)methanamine hydrochloride AldrichCPR C6H15ClN2O
CBR00925 1-[4-(Methylsulfonyl)-2-morpholinyl]methanamine hydrochloride AldrichCPR C6H15ClN2O3S
CBR00946 2-Morpholin-4-ylpropanoic acid hydrochloride AldrichCPR C7H14ClNO3
CBR00660 2-Morpholin-4-ylpropanohydrazide dihydrochloride AldrichCPR C7H17Cl2N3O2
728446 4-(4-Chlorobutyl)morpholine hydrochloride 97.0-103.0% (T) C8H16ClNO · HCl
CBR00867 3-Isobutylmorpholine hydrochloride AldrichCPR C8H18ClNO
CBR00675 trans-4-(4-Morpholinyl)-3-pyrrolidinol dihydrochloride AldrichCPR C8H18Cl2N2O2
ADE000245 4-(3-Iodo-pyridin-2-yl)-morpholine AldrichCPR C9H11IN2O
ADE001299 4-(5-Iodo-pyridin-2-yl)-morpholine AldrichCPR C9H11IN2O
ADE000685 5-Bromo-2-morpholinopyridin-3-amine AldrichCPR C9H12BrN3O
CBR00624 4-Piperidin-4-ylthiomorpholine dihydrochloride AldrichCPR C9H20Cl2N2S
CBR00637 (5-Morpholin-4-ylpentyl)amine dihydrochloride AldrichCPR C9H22Cl2N2O
CBR00221 4-[(6-Chloro-3-pyridinyl)carbonyl]morpholine AldrichCPR C10H11ClN2O2
CDS003639 1-bromo-3-(4-morpholino)benzene AldrichCPR C10H12BrNO
591777 4-(4-Bromophenyl)morpholine 97% C10H12BrNO
736406 4-(4-Iodophenyl)morpholine 97% C10H12INO
CDS010500 3-(4-fluorophenyl) morpholine hydrochloride AldrichCPR C10H13ClFNO
CBR00388 4-(4-Chloro-6-ethylpyrimidin-2-yl)morpholine AldrichCPR C10H14ClN3O
CBR00614 4-(Piperidin-3-ylmethyl)morpholine dihydrochloride hydrate AldrichCPR C10H24Cl2N2O2
ANV00034 (4-Bromophenyl)(morpholino)methanone AldrichCPR C11H12BrNO2
CDS013525 2-fluoro-4-(N-morpholino)-benzaldehyde AldrichCPR C11H12FNO2
CBR00622 4-(1-Piperidin-4-ylethyl)morpholine dihydrochloride AldrichCPR C11H24Cl2N2O
CBR00740 [2-(Morpholin-4-ylmethyl)phenyl]methanol hydrochloride AldrichCPR C12H18ClNO2
ADE000259 4-(3-Trimethylsilanylethynyl-pyridin-2-yl)-morpholine AldrichCPR C14H20N2OSi