Oxadiazoles

Oxadiazoles are five-membered heterocyclic aromatic compounds consisting of one oxygen atom, two nitrogen atoms and two carbon atoms. Depending on the placement of the nitrogens in the ring, several isomers exist such as 1,2,4-; 1,2,5-; and 1,3,4-oxadiazole. Oxadiazoles form a major class of compounds with a heterocyclic nucleus for drug development and were among the first effective chemotherapeutic and antibiotic agents. Interest in oxadiazoles ranges from medicinal chemistry to the polymer industry. Oxadiazoles have antibacterial, anti-inflammatory, anticonvulsant, anticancer, antitubercular, anti-diabetic, antihelmintic, and analgesic CNS depressant activities, among others. Due to their broad biological activity potentials, the synthesis of oxadiazole derivatives is of interest to medicinal chemists working in drug development. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Bis(2-methoxyethyl)aminosulfur Trifluoride (Deoxo-Fluor®)

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CBR01826 3-Chloro-5-methyl-1,2,4-oxadiazole AldrichCPR C3H3ClN2O
CDS019857 (1,2,4-Oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C3H6ClN3O
CDS019758 5-(Chloromethyl)-3-methyl-1,2,4-oxadiazole AldrichCPR C4H5ClN2O
CBR01426 3-(Aminomethyl)-1,2,4-oxadiazole-5-carboxamide hydrochloride AldrichCPR C4H7ClN4O2
CBR01043 1-(5-Methyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C4H8ClN3O
CBR01672 2-[5-(Trifluoromethyl)-1,2,4-oxadiazol-3-yl]ethanamine hydrochloride AldrichCPR C5H7ClF3N3O
CBR00271 5-(Chloromethyl)-3-[(methylthio)methyl]-1,2,4-oxadiazole AldrichCPR C5H7ClN2OS
CBR00747 1-(3-Ethyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C5H10ClN3O
CBR01557 1-(5-Ethyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C5H10ClN3O
CBR01684 N-Methyl-2-(1,2,4-oxadiazol-3-yl)ethanamine hydrochloride AldrichCPR C5H10ClN3O
163260 4-Chloro-7-nitrobenzofurazan 98% C6H2ClN3O3
659118 5-Chlorobenzofurazan 97% C6H3ClN2O
391395 5-Chlorobenzofurazan 3-oxide 97% C6H3ClN2O2
CBR00147 3-(Chloromethyl)-5-cyclopropyl-1,2,4-oxadiazole AldrichCPR C6H7ClN2O
CBR00843 1-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C6H10ClN3O
CDS020360 5-Azetidin-3-yl-3-methyl-1,2,4-oxadiazole hydrochloride AldrichCPR C6H10ClN3O
CBR00748 1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C6H12ClN3O
CBR00807 1-(5-Isopropyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C6H12ClN3O
CBR00749 2-(3-Ethyl-1,2,4-oxadiazol-5-yl)ethanamine hydrochloride AldrichCPR C6H12ClN3O
CBR00861 N-Methyl-2-(5-methyl-1,2,4-oxadiazol-3-yl)ethanamine hydrochloride AldrichCPR C6H12ClN3O
CDS014875 4-(bromomethyl)-2,1,3-benzoxadiazole AldrichCPR C7H5BrN2O
CDS017253 3-(chloromethyl)-5-(3-thienyl)-1,2,4-oxadiazole AldrichCPR C7H5ClN2OS
CDS010845 5-(chloromethyl)-3-(2-thienyl)-1,2,4-oxadiazole AldrichCPR C7H5ClN2OS
CBR00841 1-(3-tert-Butyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C7H14ClN3O
CBR00800 N-Methyl-1-(3-propyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C7H14ClN3O
CDS008067 3-(4-bromophenyl)-1,2,4-oxadiazole AldrichCPR C8H5BrN2O
CBR01758 5-Chloro-3-phenyl-1,2,4-oxadiazole AldrichCPR C8H5ClN2O
675032 5-(4-Chlorophenyl)-1,3,4-oxadiazole-2-thiol 97% C8H5ClN2OS
CDS011221 5-(3-bromophenyl)-1,3,4-oxadiazol-2-amine AldrichCPR C8H6BrN3O
663425 2-Amino-5-(2-chlorophenyl)-1,3,4-oxadiazole 97% C8H6ClN3O
663387 2-Amino-5-(4-chlorophenyl)-1,3,4-oxadiazole 95% C8H6ClN3O
CBR00508 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]pyridine AldrichCPR C8H6ClN3O
CBR00540 3-[5-(Chloromethyl)-1,3,4-oxadiazol-2-yl]pyridine AldrichCPR C8H6ClN3O
CDS010669 5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-ylamine AldrichCPR C8H6FN3O
CBR01018 (2,1,3-Benzoxadiazol-5-ylmethyl)methylamine hydrochloride AldrichCPR C8H10ClN3O
CBR00729 1-(3-Ethyl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate AldrichCPR C8H12F3N3O3
CBR00801 2-(3-Methyl-1,2,4-oxadiazol-5-yl)piperidine hydrochloride AldrichCPR C8H14ClN3O
CBR00862 2-(5-Isopropyl-1,2,4-oxadiazol-3-yl)-N-methylethanamine hydrochloride AldrichCPR C8H16ClN3O
CDS014341 5-phenyl-1,3,4-oxadiazole-2-carbonyl chloride AldrichCPR C9H5ClN2O2
CDS009623 2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole AldrichCPR C9H6Cl2N2O
CDS019646 2-(4-Bromophenyl)-5-methyl-1,3,4-oxadiazole AldrichCPR C9H7BrN2O
CDS004289 3-(4-Bromophenyl)-5-methyl-1,2,4-oxadiazole AldrichCPR C9H7BrN2O
CBR01391 2-(Chloromethyl)-5-phenyl-1,3,4-oxadiazole AldrichCPR C9H7ClN2O
CDS004077 3-(Chloromethyl)-5-phenyl-1,2,4-oxadiazole AldrichCPR C9H7ClN2O
CDS004119 5-(Chloromethyl)-3-phenyl-1,2,4-oxadiazole AldrichCPR C9H7ClN2O
CBR01044 1-(3-Phenyl-1,2,4-oxadiazol-5-yl)methanamine hydrochloride AldrichCPR C9H10ClN3O
CBR00792 1-(5-Phenyl-1,2,4-oxadiazol-3-yl)methanamine hydrochloride AldrichCPR C9H10ClN3O
CBR00726 1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)-N-methylmethanamine trifluoroacetate AldrichCPR C9H14F3N3O3
CBR00730 1-(3-Isopropyl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate AldrichCPR C9H14F3N3O3
CDS015896 2-[4-(bromomethyl)phenyl]-5-methyl-1,3,4-oxadiazole AldrichCPR C10H9BrN2O
CDS014526 3-[4-(bromomethyl)phenyl]-5-methyl-1,2,4-oxadiazole AldrichCPR C10H9BrN2O
CDS013702 3-(chloromethyl)-5-(4-methoxyphenyl)-1,2,4-oxadiazole AldrichCPR C10H9ClN2O2
CBR00733 1-(3-Pyridin-2-yl-1,2,4-oxadiazol-5-yl)methanamine trifluoroacetate AldrichCPR C10H9F3N4O3
CBR01074 1-(3-Pyridin-3-yl-1,2,4-oxadiazol-5-yl)methanamine trifluoroacetate salt AldrichCPR C10H9F3N4O3
CDS001715 1-[3-(2-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-ethylamine AldrichCPR C10H10ClN3O
CDS005619 1-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]ethanamine AldrichCPR C10H10ClN3O
CDS016993 3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]propanoic acid AldrichCPR C11H9FN2O3
CDS008066 3-(4-bromophenyl)-5-isopropyl-1,2,4-oxadiazole AldrichCPR C11H11BrN2O
CBR01069 1-(3-Pyridin-2-yl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate salt AldrichCPR C11H11F3N4O3
CBR01070 1-(3-Pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate salt AldrichCPR C11H11F3N4O3
CBR01071 1-(3-Pyridin-4-yl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate salt AldrichCPR C11H11F3N4O3
CBR01073 2-(3-Pyridin-2-yl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate salt AldrichCPR C11H11F3N4O3
CBR01075 2-(3-Pyridin-3-yl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate salt AldrichCPR C11H11F3N4O3
CBR00727 N-Methyl-1-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)methanamine trifluoroacetate AldrichCPR C11H11F3N4O3
CBR00728 N-Methyl-1-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)methanamine trifluoroacetate AldrichCPR C11H11F3N4O3
CBR00731 1-(3-Phenyl-1,2,4-oxadiazol-5-yl)ethanamine trifluoroacetate AldrichCPR C12H12F3N3O3
CDS019135 2-[3-(3-Fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine AldrichCPR C13H14FN3O
CDS019229 3-[3-(4-Fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine AldrichCPR C13H14FN3O
CDS010866 4-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]piperidine AldrichCPR C13H14FN3O
553646 2-(4-Bromophenyl)-5-phenyl-1,3,4-oxadiazole 96% C14H9BrN2O