Piperazines

The piperazine scaffold has been classified as a privileged structure and is frequently found in biologically active compounds across a number of different therapeutic areas. Some of these therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Simple N-substituted piperazines are found in numerous drug molecules. Sigma-Aldrich has a large selection of piperazine compounds that can be used as building blocks for organic synthesis and medicinal chemistry. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Piperazines

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CDS013269 4-formylpiperazine-1-sulfonyl chloride AldrichCPR C5H9ClN2O3S
716324 2-(Trifluoromethyl)piperazine 95% C5H9F3N2
CDS006104 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]piperazine hydrochloride AldrichCPR C6H8ClF3N4
CDS003848 Trifluoroacetylpiperazine AldrichCPR C6H9F3N2O
CDS012281 1,3-dimethylpiperazin-2-one hydrochloride AldrichCPR C6H13ClN2O
CBR00872 4-Ethylpiperazine-1-sulfonyl chloride hydrochloride AldrichCPR C6H14Cl2N2O2S
CBR00969 2-Ethylpiperazine dihydrochloride AldrichCPR C6H16Cl2N2
CDS011390 1-prop-2-ynylpiperazine dihydrochloride AldrichCPR C7H14Cl2N2
CBR00710 1-Ethyl-3-methylpiperazin-2-one hydrobromide AldrichCPR C7H15BrN2O
CDS011887 3-ethyl-1-methyl-2-piperazinone hydrochloride AldrichCPR C7H15ClN2O
CBR01724 Methyl 1-piperazinylacetate dihydrochloride AldrichCPR C7H16Cl2N2O2
CDS019712 1-(2-Bromoethyl)-4-methylpiperazine dihydrobromide AldrichCPR C7H17Br3N2
CBR01566 1-(4H-1,2,4-Triazol-3-ylmethyl)piperazine dihydrochloride hydrate AldrichCPR C7H17Cl2N5O
CBR00658 1,3,3-Trimethylpiperazine dihydrochloride AldrichCPR C7H18Cl2N2
CDS003264 5-bromo-2-(piperazin-1-yl)pyrimidine AldrichCPR C8H11BrN4
CDS010617 cyclopropylcarboxylic acid-1-piperazinoamide hydrochloride AldrichCPR C8H15ClN2O
CBR00847 3-Isopropyl-1-methylpiperazin-2-one hydrochloride AldrichCPR C8H17ClN2O
CDS004562 3-(4-Methylpiperazin-1-yl)propan-1-ol AldrichCPR C8H18N2O
CDS014533 1-(3-chloropropyl)-4-methylpiperazine dihydrochloride AldrichCPR C8H19Cl3N2
CBR00670 1-Ethyl-2,2-dimethylpiperazine dihydrochloride AldrichCPR C8H20Cl2N2
CBR00630 4-Piperazin-1-ylbutan-1-ol dihydrochloride AldrichCPR C8H20Cl2N2O
CBR01078 1-[2-(1H-1,2,4-Triazol-1-yl)ethyl]piperazine trihydrochloride hydrate AldrichCPR C8H20Cl3N5O
ADE000718 1-(5-Bromo-3-nitropyridin-2-yl)piperazine AldrichCPR C9H11BrN4O2
ADE000247 1-(5-Iodo-pyridin-2-yl)-piperazine AldrichCPR C9H12IN3
CBR00711 1-Isobutyl-3-methylpiperazin-2-one hydrobromide AldrichCPR C9H19BrN2O
CBR01720 1-(Tetrahydro-2H-pyran-4-yl)piperazine dihydrochloride AldrichCPR C9H20Cl2N2O
CBR01565 1-Methyl-4-(3-pyrrolidinyl)piperazine trihydrochloride AldrichCPR C9H22Cl3N3
CBR01564 trans-4-(4-Methyl-1-piperazinyl)tetrahydro-3-furanamine trihydrochloride AldrichCPR C9H22Cl3N3O
CDS013737 1-(4-chloro-2-fluorophenyl)piperazine AldrichCPR C10H12ClFN2
CDS014767 1-(3,5-dichlorophenyl)piperazine AldrichCPR C10H12Cl2N2
CDS020409 1-(2,3-Difluorophenyl)piperazine AldrichCPR C10H12F2N2
CDS018547 1-[2-(trifluoromethyl)pyridin-4-yl]piperazine AldrichCPR C10H12F3N3
CDS014957 1-[3-(trifluoromethyl)pyrid-2-yl]piperazine AldrichCPR C10H12F3N3
CDS014669 1-(3-bromophenyl)piperazine AldrichCPR C10H13BrN2
724580 1-(4-bromophenyl)piperazine 95% C10H13BrN2
C67605 1-(2-Chlorophenyl)piperazine monohydrochloride 95% C10H13ClN2 · HCl
125180 1-(3-Chlorophenyl)piperazine hydrochloride 99% C10H13ClN2 · xHCl
C68008 1-(4-Chlorophenyl)piperazine dihydrochloride 95% C10H13ClN2 · 2HCl
679135 1-(2,3-Dichlorophenyl)piperazine hydrochloride 97% C10H13Cl3N2
CDS018430 2-(2-fluoro-phenyl)-piperazine AldrichCPR C10H13FN2
647268 1-(4-Iodophenyl)piperazine hydrochloride 95% C10H13IN2 · HCl
CDS004799 5-bromo-2-(4-methylpiperazin-1-yl)pyridine AldrichCPR C10H14BrN3
CDS014030 1-(2,5-dichlorophenyl)piperazine dihydrochloride AldrichCPR C10H14Cl4N2
CDS002717 1-(3-Pyridinylmethyl)piperazine hydrochloride AldrichCPR C10H16ClN3
CBR01441 4-Ethyl-6-(1-piperazinyl)pyrimidine dihydrochloride hydrate AldrichCPR C10H20Cl2N4O
CBR00603 2-[4-(2-Pyrimidinyl)-1-piperazinyl]ethanamine trihydrochloride AldrichCPR C10H20Cl3N5
CDS013334 (3-fluoro-phenyl)-piperazin-1-yl-methanone AldrichCPR C11H13FN2O
CDS015257 1-(2-trifluoromethylphenyl)-piperazine AldrichCPR C11H13F3N2
CDS009461 2-(4-trifluoromethylphenyl)piperazine AldrichCPR C11H13F3N2
657719 1-(4-Bromo-2-fluorobenzyl)piperazine 96% C11H14BrFN2
650156 1-(2-Chloro-6-fluorobenzyl)piperazine 98% C11H14ClFN2
657832 1-(2,6-Dichlorobenzyl)piperazine 97% C11H14Cl2N2
644269 1-(3,4-Dichlorobenzyl)piperazine 97% C11H14Cl2N2
650234 1-(4-Bromobenzyl)piperazine 97% C11H15BrN2
650218 1-(4-Chlorobenzyl)piperazine 98% C11H15ClN2
CDS001660 1-[4-Chloro-2-(methylsulfonyl)phenyl]piperazine AldrichCPR C11H15ClN2O2S
CBR00746 3-Methyl-1-phenylpiperazine hydrochloride AldrichCPR C11H17ClN2
CBR00615 1-Methyl-2-phenylpiperazine dihydrochloride hydrate AldrichCPR C11H20Cl2N2O
CBR01440 1-Methyl-4-(3-piperidinylMethyl)piperazine trihydrochloride AldrichCPR C11H26Cl3N3
CDS006254 1-(2-bromo-benzyl)-4-methylpiperazine AldrichCPR C12H17BrN2
CBR00802 1-(2-Phenylethyl)piperazin-2-one hydrochloride AldrichCPR C12H17ClN2O
CBR00767 1-(3-Methylbenzyl)piperazin-2-one hydrochloride AldrichCPR C12H17ClN2O
CBR00768 1-(3-Methoxybenzyl)piperazin-2-one hydrochloride AldrichCPR C12H17ClN2O2
CDS006850 4-(1-Piperazinyl)-1H-indole dihydrochloride AldrichCPR C12H17Cl2N3
CBR01011 3-Methyl-1-(2-methylphenyl)piperazine hydrochloride AldrichCPR C12H19ClN2
CBR00654 1-(2-Chloroethyl)-4-phenylpiperazine dihydrochloride AldrichCPR C12H19Cl3N2
CBR00725 1-Cyclohexylpiperazin-2-one trifluoroacetate AldrichCPR C12H19F3N2O3
CBR00981 3-Methyl-1-(4-methylphenyl)piperazine dihydrochloride hydrate AldrichCPR C12H22Cl2N2O
CBR00602 1-Methyl-4-(1-piperidin-4-ylethyl)piperazine trihydrochloride dihydrate AldrichCPR C12H32Cl3N3O2
CDS013845 5-piperazin-1-yl-2-(trifluoromethyl)-1,6-naphthyridine AldrichCPR C13H13F3N4
CDS018459 7-chloro-4-piperazin-1-yl-quinoline AldrichCPR C13H14ClN3
CDS004809 6-Bromo-4-(4-methyl-1-piperazinyl)quinazoline AldrichCPR C13H15BrN4
363464 1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine monohydrochloride 97% C13H18Cl2N2 · HCl
CBR00769 1-(3,5-Dimethylbenzyl)piperazin-2-one hydrochloride AldrichCPR C13H19ClN2O
CDS005235 tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate AldrichCPR C13H19ClN4O2
CBR00636 1-(3-Methoxyphenyl)-2,2-dimethylpiperazine dihydrochloride AldrichCPR C13H22Cl2N2O
653764 4-Boc-1-(5-bromo-2-pyridyl)piperazine 97% C14H20BrN3O2
653772 4-Boc-1-(6-bromo-2-pyridyl)piperazine 97% C14H20BrN3O2
CBR00950 2-(4-Methyl-6-piperazin-1-ylpyrimidin-2-yl)phenol hydrochloride AldrichCPR C15H19ClN4O
ADE001000 tert-Butyl 4-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate AldrichCPR C16H21ClN4O2
C24507 1-(4-Chlorobenzhydryl)piperazine technical grade, 90% C17H19ClN2
44264 2-(4-Boc-piperazino)-2-(4-fluorophenyl)acetic acid purum, ≥97.0% (HPLC) C17H23FN2O4
CDS010353 t-butyl4-(2-Amino-1-[4-(trifluoromethyl)phenyl]ethyl)piperazine carboxylate AldrichCPR C18H26F3N3O2
666254 4-((5-Bromo-2-thienyl)(2-hydroxyphenyl)methyl)-1-Boc-piperazine 97% C20H25BrN2O3S
ADE001001 tert-Butyl 4-(5-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate AldrichCPR C25H41ClN4O2Si