Pyrroles

Pyrroles (1H-pyrroles) are heterocyclic aromatic compounds consisting of a five-membered ring containing a nitrogen atom. Pyrroles are important synthons in the synthesis of natural products. They exhibit remarkable biological properties such as hypolipidemic, antimicrobial, anti-inflammatory and antitumour activities and are able to inhibit retroviral reverse transcriptases [i.e., human immunodeficiency virus type 1 (HIV-1)], cellular DNA polymerases and protein kinases. Furthermore, some of these compounds are useful intermediates in the synthesis of biologically important naturally occurring alkaloids and unnatural heterocyclic derivatives. Phosphino-substituted N-aryl pyrroles, a novel class of sterically demanding and electron rich biaryl phosphine ligands, exhibit high turnover rates and low catalyst loadings. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Acetylenic Schmidt Reaction
Intermolecular Hydroamination
cataCXium®
(2-Trimethylsilyl)-ethanesulfonyl Reagents
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CBR01780 4-Bromo-1H-pyrrole-2-carbonitrile AldrichCPR C5H3BrN2
395137 2-(Trichloroacetyl)pyrrole 99% C6H4Cl3NO
CBR01807 4-Bromo-1-methyl-1H-pyrrole-2-carbonitrile AldrichCPR C6H5BrN2
CBR01756 4-Bromo-1,5-dimethyl-1H-pyrrole-2-carbonitrile AldrichCPR C7H7BrN2
CBR01774 4-Bromo-1-ethyl-1H-pyrrole-2-carbonitrile AldrichCPR C7H7BrN2
CBR01832 4-Bromo-5-ethyl-1H-pyrrole-2-carbonitrile AldrichCPR C7H7BrN2
729787 Ethyl 4-bromopyrrole-2-carboxylate 97% C7H8BrNO2
ANV00082 Methyl 4-bromo-1-methyl-1H-pyrrole-2-carboxylate AldrichCPR C7H8BrNO2
ANV00044 Methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate hydrochloride AldrichCPR C7H11ClN2O2
452947 1-(4-Chlorophenyl)-1H-pyrrole 97% C10H8ClN
CDS017043 2-chloro-5-pyrrol-1-yl-benzoic acid AldrichCPR C11H8ClNO2
709808 3-Bromo-1(triisopropysilyl)pyrrole 97% C13H24BrNSi