Tetrazoles have applications in both materials science and pharmaceuticals. Tetrazoles can tolerate a wide range of chemical environments, from strongly acidic to basic as well as oxidizing and reducing conditions. Tetrazoles are metabolically stable bioisosteres of the carboxylic acid group, and can serve as precursors to a variety of nitrogen-containing heterocycles by the Huisgen rearrangement. They also function as simple lipophilic spacers displaying two substituents in the appropriate manner, where the connectivity patterns of the embedded tetrazole units bear a striking resemblance to those of their 1,2,3-triazole analogues. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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CBR01707 5-(Trifluoromethyl)-1H-tetrazole hydrate AldrichCPR C2H3F3N4O
CBR00176 5-Iodo-1-methyl-1H-tetrazole AldrichCPR C2H3IN4
CBR00786 2-[(1-Methyl-1H-tetrazol-5-yl)thio]ethanamine hydrochloride AldrichCPR C4H10ClN5S
646180 5-(5-Bromo-2-thienyl)-1H-tetrazole solution 30% in DMF C5H3BrN4S
556068 5-(5-Bromo-3-pyridyl)-1H-tetrazole 97% C6H4BrN5
JRD0208 5-(2,4-Dichlorophenyl)-1H-tetrazole AldrichCPR C7H4Cl2N4
439541 5-(2-Bromophenyl)-1H-tetrazole 98% C7H5BrN4
649570 5-(4-Bromophenyl)-1H-tetrazole 97% C7H5BrN4
CDS000761 5-(3-Chlorophenyl)-1H-tetrazole AldrichCPR C7H5ClN4
763527 5-(4-Chlorophenyl)-1H-tetrazole 97% C7H5ClN4
143375 5-Chloro-1-phenyl-1H-tetrazole 97% C7H5ClN4
681091 5-(4-Fluorophenyl)-1H-tetrazole 95% C7H5FN4
I10406 Iodonitrotetrazolium chloride 95% C19H13ClIN5O2